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BMC Medicine 2013, 11:192. doi:10.1186/1741-7015-11-192
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Alfredo Gea
Juan J Beunza
Ram�n Estruch
Almudena S�nchez-Villegas
Jordi Salas-Salvad�
Pilar Buil-Cosiales
Enrique G�mez-Gracia
Mar�a-Isabel Covas
Dolores Corella
Miquel Fiol
Fernando Ar�s
Jos� Lapetra
Rosa-Mar�a Lamuela-Ravent�s
Julia W�rnberg
Xavier Pint�
Lluis Serra-Majem
Miguel A Mart�nez-Gonz�lez
Alcohol intake, wine consumption and the development of depression: the PREDIMED study
BMC Medicine 2013, 11:192. doi:10.1186/1741-7015-11-192
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2013-08-30
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(3,9) Tj
10.4498996735 0 0 11.0001001358 329.4424133301 588.6990966797 Tm
[(,) -300.6000061035 (Dolores) -298.3999938965 (Corella) ] TJ
7.8372001648 0 0 7.3326997757 397.8140869141 593.5747070312 Tm
(3,10) Tj
10.4498996735 0 0 11.0001001358 410.3999023438 588.6990966797 Tm
[(,) -300.6000061035 (Miquel) -306.700012207 (Fiol) ] TJ
7.8372001648 0 0 7.3326997757 461.6502990723 593.5747070312 Tm
(3,11) Tj
10.4498996735 0 0 11.0001001358 474.236114502 588.6990966797 Tm
(,) Tj
-39.9566001892 -1.2730000019 TD
[(Fernando) -303.299987793 <4172F373> ] TJ
7.8372001648 0 0 7.3326997757 118.1480026245 579.571472168 Tm
(3,12) Tj
10.4498996735 0 0 11.0001001358 130.733795166 574.6959228516 Tm
[(,) -300.6000061035 <4A6F73E9> -301.200012207 (Lapetra) ] TJ
7.8372001648 0 0 7.3326997757 187.653503418 579.571472168 Tm
(3,13) Tj
10.4498996735 0 0 11.0001001358 200.1826019287 574.6959228516 Tm
[(,) -300.6000061035 <526F73612D4D6172ED61> -310 <4C616D75656C612D526176656E74F373> ] TJ
7.8372001648 0 0 7.3326997757 329.0455932617 579.571472168 Tm
(3,14) Tj
10.4498996735 0 0 11.0001001358 341.6314086914 574.6959228516 Tm
[(,) -300.6000061035 (Julia) -303 <57E4726E62657267> ] TJ
7.8372001648 0 0 7.3326997757 408.8125 579.571472168 Tm
(3,8) Tj
10.4498996735 0 0 11.0001001358 417.6565856934 574.6959228516 Tm
[(,) -300.6000061035 (Xavier) -305 <50696E74F3> ] TJ
7.8372001648 0 0 7.3326997757 472.592010498 579.571472168 Tm
(3,15) Tj
10.4498996735 0 0 11.0001001358 485.1211853027 574.6959228516 Tm
(,) Tj
-40.9981994629 -1.2730000019 TD
[(Lluis) -303.700012207 (Serra-Majem) ] TJ
7.8372001648 0 0 7.3326997757 130.1669006348 565.5684204102 Tm
(3,5) Tj
10.4498996735 0 0 11.0001001358 142.0724029541 560.6928100586 Tm
[(and) -303.8999938965 (Miguel) -301.299987793 (A) -301.299987793 <4D617274ED6E657A2D476F6E7AE16C657A> ] TJ
7.8372001648 0 0 7.3326997757 278.5321960449 565.5684204102 Tm
(1,3*) Tj
10.4498996735 0 0 11.0001001358 290.3810119629 560.6928100586 Tm
[(,) -300.6000061035 (for) -301.3999938965 (the) -299.299987793 (PREDIMED) -302.700012207 (GROUP) ] TJ
/F5 1 Tf
10.3000001907 0 0 10.3000001907 63.212600708 522.1983032227 Tm
(Abstract) Tj
/F6 1 Tf
10.0001001358 0 0 10.0001001358 63.212600708 504.2267150879 Tm
(Background:) Tj
/F2 1 Tf
5.7430000305 0 TD
[(Alcoholic) -305.8999938965 (beverages) -308.700012207 (are) -302.3999938965 (widely) -306 (consumed.) -307.6000061035 (Depression,) -310.700012207 (the) -298.1000061035 (most) -304.1000061035 (prevalent) -305.8999938965 (me) -7.3000001907 (ntal) -297.799987793 (disor) -9.6000003815 (der) ] TJ
-5.7430000305 -1.2019000053 TD
[(worldwide,) -310.200012207 (has) -302.1000061035 (been) -300.1000061035 (related) -308.799987793 (to) -300.8999938965 (alcohol) -304.5 (intake.) -302.700012207 (We) -302.1000061035 (aimed) -308 (to) -300.8999938965 (prospectively) -308 (assess) -305.299987793 (th) -6.0999999046 (e) -297.700012207 (associatio) -10.5 (n) -296.700012207 (between) -309.1000061035 (alcohol) ] TJ
T*
[(intake) -304.299987793 (and) -300.8999938965 (incident) -306.299987793 (depressi) -9.8999996185 (on) -298.6000061035 (using) -302.200012207 (re) -6.6999998093 (peated) -300.799987793 (measure) -9.6000003815 (ments) -301.299987793 (of) -303.200012207 (alcohol) -304.5 (intake.) ] TJ
/F6 1 Tf
0 -1.4967000484 TD
(Methods:) Tj
/F2 1 Tf
4.3200001717 0 TD
[(We) -302.1000061035 (follo) -8.1999998093 (wed-up) -305.8999938965 (5,505) -299.1000061035 (hig) -6.9000000954 (h-risk) -302.799987793 (men) -304 (and) -300.8999938965 (women) -307.8999938965 (\(55) -301.3999938965 (to) -300.8999938965 (80) -300.6000061035 (y\)) -300.799987793 (of) -303.200012207 (the) -298.1000061035 (PREDI) -7.8000001907 (MED) -304 (Trial) -304.200012207 (for) -301.299987793 (up) -299.6000061035 (to) -300.8999938965 (seven) ] TJ
-4.3200001717 -1.2019000053 TD
[(years.) -304.799987793 (Participants) -309 (were) -300.700012207 (initial) -8.3000001907 (ly) -301.799987793 (free) -299.5 (of) -303.200012207 (depression) -308.5 (or) -300.5 (a) -301.299987793 (history) -306.700012207 (of) -303.200012207 (depression,) -307 (and) -300.799987793 (did) -303.1000061035 (not) -302.799987793 (have) -307 (any) -302.799987793 (history) -301.1000061035 (of) ] TJ
T*
[(alcohol-related) -311 (problems.) -307.700012207 (A) -301.3999938965 (137-item) -303.5 (validate) -10.8000001907 (d) -298 (food) -302.700012207 (freque) -9.6000003815 (ncy) -301.5 (questionnaire) -311.1000061035 (administered) -307.6000061035 (by) -303.299987793 (a) -301.299987793 (dietician) -307.1000061035 (was) ] TJ
0 -1.1962000132 TD
[(repeated) -307.5 (annually) -305.1000061035 (to) -300.8999938965 (assess) -305.299987793 (alcohol) -304.5 (intake.) -308.3999938965 (Participants) -309 (were) -300.700012207 (cla) -7.8000001907 (ssified) -302.8999938965 (as) -300.200012207 (incid) -8.1999998093 (ent) -298.1000061035 (cases) -307.1000061035 (of) -297.5 (depres) -9.3000001907 (sion) -299.200012207 (when) -303.5 (th) -6.0999999046 (ey) ] TJ
0 -1.2019000053 TD
[(reported) -303.799987793 (a) -301.299987793 (new) -301.6000061035 (clinical) -309.3999938965 (diagnosis) -307.299987793 (of) -303.200012207 (depression,) -307 (and/or) -303.700012207 (initiated) -306 (th) -6.0999999046 (e) -297.700012207 (use) -303.799987793 (of) -303.200012207 (antidepressant) -307.299987793 (dr) -7.0999999046 (ugs.) -302.6000061035 (Cox) -299.8999938965 (regr) -8.1000003815 (ession) ] TJ
T*
[(analyses) -306 (were) -300.700012207 (fitted) -306.1000061035 (over) -304.299987793 (23,655) -302 (person-y) -10.3000001907 (ears.) ] TJ
/F6 1 Tf
0 -1.4967000484 TD
(Results:) Tj
/F2 1 Tf
3.5943000317 0 TD
[(Moderate) -304.299987793 (alcohol) -304.5 (intake) -309.8999938965 (within) -302.700012207 (the) -298.1000061035 (range) -307.6000061035 (of) -303.200012207 (5) -297.700012207 (t) 0 (o) -300.8999938965 (1) 0 (5) -300.6000061035 (g/day) -310.200012207 (was) -302.200012207 (significantly) -307 (associated) -313.3999938965 (with) -299 (lower) -307.200012207 (risk) -302.700012207 (of) ] TJ
-3.5943000317 -1.2019000053 TD
[(incident) -306.299987793 (depression) -308.5 (\(hazard) -302.5 (ratio) -307.299987793 (\(HR\)) -299.6000061035 (and) -306.5 (95%) -302.8999938965 (confidence) -305.6000061035 (interval) -307.200012207 (\(95%) -303.700012207 (CI\)) -302.299987793 (=) -297.1000061035 (0.72) -307.6000061035 (\(0.53) -302.700012207 (to) -300.8999938965 (0.98\)) -302.700012207 (versus) -307.299987793 (abstainers\).) ] TJ
T*
[(Specifically,) -308 (wine) -303.3999938965 (consumpt) -9.8999996185 (ion) -300.3999938965 (in) -298.5 (th) -6.0999999046 (e) -297.700012207 (range) -307.6000061035 (of) -297.5 (two) -302.8999938965 (to) -300.8999938965 (seven) -307.8999938965 (drinks/week) -310.799987793 (was) -302.200012207 (significantly) -307 (associated) -313.3999938965 (with) -299 (lower) ] TJ
0 -1.1962000132 TD
[(rates) -299.700012207 (of) -303.200012207 (depressi) -9.8999996185 (on) -298.6000061035 (\(HR) -304.5 (\(95%) -298.1000061035 (CI) -6.6999998093 (\)) -295.6000061035 (=) -302.700012207 (0.68) -301.8999938965 (\(0.47) -302.700012207 (to) -306.5 (0.98\)\).) ] TJ
/F6 1 Tf
0 -1.5024000406 TD
(Conclusions:) Tj
/F2 1 Tf
5.7088999748 0 TD
[(Moderate) -310 (consumption) -304.700012207 (of) -303.200012207 (wine) -303.3999938965 (may) -305.299987793 (reduce) -303.1000061035 (the) -303.799987793 (incidence) -304.6000061035 (of) -303.200012207 (depressi) -9.8999996185 (on,) -297.1000061035 (whil) -7.5 (e) -297.700012207 (heavy) -306.6000061035 (drinkers) -309 (seem) ] TJ
-5.7088999748 -1.2019000053 TD
[(to) -300.8999938965 (be) -300.8999938965 (at) -299.799987793 (higher) -304.700012207 (risk.) ] TJ
/F6 1 Tf
0 -1.6950999498 TD
(Keywords:) Tj
/F2 1 Tf
4.7621998787 0 TD
[(Wine,) -304.200012207 (Alcohol,) -303 (Depre) -8.5 (ssion,) -302.200012207 (Cohort) ] TJ
/F5 1 Tf
10.3000001907 0 0 10.3000001907 56.6929016113 279.7228088379 Tm
[(Backgroun) -13.6000003815 (d) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 267.7605895996 Tm
[(Most) -368.299987793 (cult) -9.3000001907 (ures) -369.299987793 (and) -367.5 (countrie) -12.8000001907 (s) -367.1000061035 (include) -369.3999938965 (alc) -8.8000001907 (oholic) -373.5 (be) -10.6999998093 (verages) ] TJ
0 -1.2264000177 TD
[(a) -10 (s) -517.5 (part) -517.5 (of) -519.5999755859 (their) -519.4000244141 (usu) -8.1999998093 (al) -513.5999755859 (diet.) -524.5 (Alcohol) -521.700012207 (intake) -520.700012207 (is) -517.799987793 (differ) -9.1000003815 (ent) ] TJ
T*
[(ov) 17.7000007629 (er) -265.6000061035 (wo) 13.6999998093 (rl) 16 (d) -267.299987793 (r) 0 (e) 12.1000003815 (g) 0 (i) 21.6000003815 (o) 0 (n) 13.3000001907 (s) -268.700012207 (re) 12.1000003815 (ga) 17.7000007629 (rd) 15.1000003815 (i) 11.1999998093 (n) 0 (g) -264.8999938965 (t) 0 (h) 12.6000003815 (e) -270.299987793 (ha) 16.1000003815 (bi) 16.3999996185 (tu) 12.6000003815 (al) -259.1000061035 (ty) 11.1999998093 (pe) -260 (of) -293.8999938965 (bev) 13.3999996185 (er) 12.1000003815 (ag) 17.7000007629 (e) ] TJ
0 -1.220600009 TD
[(an) 15.5 (d) -435.1000061035 (t) 0 (h) 18.3999996185 (e) -432.299987793 (pa) 11.8999996185 (tt) 19.2000007629 (er) 12.1000003815 (n) -431.5 (o) 10.8999996185 (f) -432.1000061035 (c) 0 (o) 12.5 (n) 0 (s) 17.2000007629 (u) 0 (m) 14.5 (p) 0 (t) 14.1999998093 (i) 11.1999998093 (on) -426.299987793 (\(f) 17.1000003815 (re) 12.1000003815 (qu) 19.1000003815 (en) 15.5 (cy) -425 (an) 15.5 (d) -435.1000061035 (a) 18.8999996185 (ve) 14.1000003815 (ra) 17.8999996185 (ge) ] TJ
0 -1.2264000177 TD
[(in) 13.6999998093 (ta) 16.8999996185 (ke) 15.6000003815 (\).) -466.6000061035 (In) -462.8999938965 (ge) 12 (ne) 21.2999992371 (ra) 12.1000003815 (l) -474.700012207 (t) 0 (e) 16.8999996185 (r) 0 (m) 16.2999992371 (s) -14.1999998093 (,) -470.3999938965 (t) 0 (h) 12.6000003815 (e) -484.3999938965 (co) 12.5 (ns) 17.2000007629 (um) 14.5 (pt) 20 (io) 16.3999996185 (n) -477.700012207 (o) 10.8999996185 (f) -478.3999938965 (a) 0 (l) 18.6000003815 (c) 0 (o) 12.5 (h) 0 (o) 19.7000007629 (l) 0 (i) 16.7000007629 (c) ] TJ
T*
[(bev) 13.3999996185 (er) 17.8999996185 (ag) 12 (es) -249.8000030518 (is) -251.6999969482 (in) 13.6999998093 (cr) 17.8999996185 (eas) 12.1000003815 (i) 11.1999998093 (n) 0 (g) -253.3000030518 (w) 0 (o) 13.6999998093 (r) 0 (l) 16 (d) 0 (w) 18.8999996185 (i) 0 (d) 15.8000001907 (e) -264.6000061035 ([) 9.6000003815 (1) 0 (]) 17.8999996185 (.) -262.200012207 (Un) 14.1000003815 (i) 11.1999998093 (p) 0 (o) 15.5 (l) 0 (a) 12.8000001907 (r) -255.6000061035 (de) 11.8999996185 (pr) 20.8999996185 (es) 16.2999992371 (si) 14.3999996185 (on) ] TJ
0 -1.220600009 TD
[(is) -326.8999938965 (th) 12.6000003815 (e) -339.799987793 (m) 11.5 (os) 14.1000003815 (t) -337.5 (p) 0 (r) 15.1000003815 (eva) 9.8999996185 (l) 11.1999998093 (e) 0 (n) 15.5 (t) -337.5 (me) 13.1000003815 (nt) 17.7999992371 (al) -328.5 (di) 15.8000001907 (so) 14.1000003815 (rd) 15.1000003815 (er) -329.200012207 (i) 11.1999998093 (n) -338.8999938965 (th) 12.6000003815 (e) -334 (w) 0 (o) 13.6999998093 (r) 0 (l) 16 (d) -336.799987793 (an) 15.5 (d) -336.799987793 (i) 0 (t) ] TJ
0 -1.2264000177 TD
[(is) -251.6999969482 (in) 13.6999998093 (cr) 17.8999996185 (eas) 12.1000003815 (in) 13.6999998093 (g) -261.5 (s) 0 (t) 18.6000003815 (e) 0 (a) 14.6999998093 (d) 0 (i) 15.8000001907 (l) 11.1999998093 (y) -264.6000061035 ([) 9.6000003815 (2]) 12.1000003815 (.) ] TJ
0.8156999946 -1.2264000177 TD
-0.0151000004 Tc
[(Th) -15.1000003815 (e) -357.700012207 (s) -15.1000003815 (i) 5.0999999046 (m) -15.1000003815 (ul) -15.1000003815 (ta) -15.1000003815 (ne) -15.1000003815 (ou) -15.1000003815 (s) -350.200012207 (p) -15.1000003815 (re) -15.1000003815 (se) -15.1000003815 (nc) -15.1000003815 (e) -353.299987793 (o) -15.1000003815 (f) -355.299987793 (a) -15.1000003815 (lc) -15.1000003815 (oh) -15.1000003815 (ol) -15.1000003815 (-r) -15.1000003815 (el) -15.1000003815 (at) -15.1000003815 (ed) -363.3999938965 (p) -15.1000003815 (r) 0 (ob) -15.1000003815 (le) -15.1000003815 (ms) ] TJ
-0.8156999946 -1.220600009 TD
0.0209999997 Tc
[(and) -408.299987793 (d) 2.4000000954 (epression) -410.5 (i) 3.2999999523 (s) -409.700012207 (c) -0.6000000238 (ommon) -410.5 ([) 1.7000000477 (3].) -408.8999938965 (H) -1.5 (owe) -6.4000000954 (v) -1.2000000477 (er) 72 (,) -408.8999938965 (p) 2.4000000954 (roblematic) ] TJ
25.3094997406 12.2411003113 TD
0.0207000002 Tc
[(int) -4.4000000954 (a) -0.8999999762 (ke) -284.3999938965 (need) -3.7000000477 (s) -288.5 (t) 1.3999999762 (o) -292.299987793 (b) 2.7000000477 (e) -290.1000061035 (d) -3.7000000477 (istinguished) -287.1000061035 (from) -291.700012207 (moderate) -290.1000061035 (intake.) ] TJ
0 -1.220600009 TD
-0.0175999999 Tc
[(Problema) -4.5 (t) -2.2000000477 (ic) -340 (a) -4.5 (l) -0.6000000238 (cohol) -336.1000061035 (i) -0.6000000238 (nta) -4.5 (k) 2.2000000477 (e) -340 (m) -0.3000000119 (ay) -340 (be) -340 (a) -17.6000003815 (s) 4.5 (sociated) -342.799987793 (with) -338.6000061035 (depres) -17.6000003815 (-) ] TJ
0 -1.2264000177 TD
-0.0170000009 Tc
[(sio) -6.0999999046 (n) -436.8999938965 (not) -441.299987793 (o) -0.3000000119 (nly) -437.799987793 (b) -0.3000000119 (e) -17 (c) 3.5 (ause) -437.799987793 (of) -443.299987793 (increa) -17 (sed) -446.299987793 (i) 0 (ntake) -437.799987793 (o) -0.3000000119 (f) -443.299987793 (e) -3.9000000954 (thanol) -439.6000061035 (but) ] TJ
T*
-0.0174000002 Tc
[(also) -313.1000061035 (be) -17.3999996185 (cause) -316.700012207 (o) -0.6999999881 (f) -316.5 (o) -0.6999999881 (the) -4.3000001907 (r) -313.5 (alc) -4.3000001907 (o) -0.6999999881 (hol-re) ] TJ
12.8369998932 0 TD
-0.0162000004 Tc
[(lated) -312.5 (u) 4.0999999046 (nhealthy) -309.700012207 (lifestyl) 6.5999999046 (e) -3.0999999046 (s) -313.799987793 (o) 0.5 (r) ] TJ
-12.8369998932 -1.220600009 TD
-0.0157999992 Tc
[(be) -15.8000001907 (c) 4.6999998093 (a) 3.0999999046 (us) 4.6999998093 (e) -268.799987793 (o) 0.8999999762 (f) -274.3999938965 (t) 5.4000000954 (he) -268.799987793 (social) -270.700012207 (en) 4 (viron) 4 (m) 1.5 (en) 4 (t) -283.8999938965 (s) 4.6999998093 (urr) 6.3000001907 (o) 0.8999999762 (un) 4 (ding) -265.700012207 (problemat) 5.4000000954 (ic) ] TJ
0 -1.2264000177 TD
0 Tc
[(dr) 15.1000003815 (i) 11.1999998093 (n) 0 (k) 16.5 (e) 0 (r) 12.1000003815 (s) -349.700012207 (\(j) 16.6000003815 (o) 10.8999996185 (b) -353.5 (l) 11.1999998093 (o) 0 (s) 14.1000003815 (s) -14.1999998093 (,) -348.8999938965 (f) 0 (a) 14.8999996185 (m) 11.5 (il) 16.7000007629 (y) -351.299987793 (p) 0 (r) 15.1000003815 (o) 10.8999996185 (bl) 10.6000003815 (em) 18.8999996185 (s) -14.1999998093 (,) -348.8999938965 (fi) 18.7999992371 (na) 15.5 (nc) 15.5 (ia) 12.8000001907 (l) -347.3999938965 (p) 0 (r) 15.1000003815 (o) 0 (b) 16 (l) 0 (e) 12.8000001907 (m) 11.5 (s) -349.700012207 (o) 0 (r) ] TJ
T*
[(ot) 14.6999998093 (he) 16.1000003815 (r) -429.1000061035 (a) 0 (d) 11.8999996185 (d) 0 (i) 15.8000001907 (c) 0 (t) 16.8999996185 (i) 11.1999998093 (on) 13.3000001907 (s\)) 18.6000003815 (.) -435.700012207 (A) 0 (n) 16.2000007629 (y) -432.299987793 (o) 10.8999996185 (f) -432.1000061035 (th) 12.6000003815 (e) 13.1000003815 (s) 0 (e) -434.8999938965 (c) 0 (i) 12.8000001907 (r) 0 (c) 17.8999996185 (u) 0 (m) 14.5 (s) 0 (t) 18.6000003815 (a) 0 (n) 15.5 (c) 0 (e) 14.6999998093 (s) -430.700012207 (ma) 13.1000003815 (y) -432.299987793 (b) 0 (e) -421.3999938965 (a) ] TJ
0 -1.220600009 TD
[(po) 15.5 (te) 16.8999996185 (nt) 12 (i) 11.1999998093 (a) 0 (l) -369 (t) 0 (r) 14.3999996185 (i) 11.1999998093 (gg) 15 (er) -369.700012207 (fo) 18.3999996185 (r) -377.1000061035 (d) 0 (e) 11.8999996185 (p) 0 (r) 15.1000003815 (e) 13.1000003815 (ss) 12.1999998093 (i) 11.1999998093 (o) 0 (n) 13.3000001907 (,) -377.8999938965 (eve) 15.6000003815 (n) -379.3999938965 (i) 11.1999998093 (n) -379.3999938965 (t) 0 (h) 18.3999996185 (e) -380.299987793 (ab) 12.5 (se) 16.2999992371 (nc) 15.5 (e) -374.5 (o) 0 (f) -369.200012207 (a) ] TJ
0 -1.2264000177 TD
[(sp) 13.5 (eci) 14.3000001907 (fi) 18.7999992371 (c) -264.6000061035 (d) 0 (e) 17.7000007629 (t) 0 (r) 14.3999996185 (i) 11.1999998093 (me) 13.1000003815 (nt) 17.7999992371 (al) -259.1000061035 (ro) 15.6999998093 (l) 11.1999998093 (e) -264.6000061035 (fo) 18.5 (r) -261.3999938965 (e) 0 (t) 16.8999996185 (h) 0 (a) 10.3000001907 (n) 0 (o) 19.1000003815 (l) 0 (.) ] TJ
0.8156999946 -1.2264000177 TD
-0.0143999998 Tc
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[(pr) 15 (eve) 15.5 (nt) 11.8999996185 (i) 11.1000003815 (o) -0.1000000015 (n) -547.9000244141 (o) 10.8000001907 (f) -553.700012207 (c) -0.1000000015 (a) 14.6000003815 (r) -0.1000000015 (d) 15 (i) 11.1000003815 (ov) 11.8000001907 (asc) 12 (ul) 19.8999996185 (ar) -549.200012207 (di) 21.5 (se) 10.3999996185 (ase) -543.4000244141 (\(ww) 17.1000003815 (w) -0.1000000015 (.) 12.3999996185 (p) -0.1000000015 (r) 15 (e) -0.1000000015 (d) 17.6000003815 (i) 11.1000003815 (me) 13 (d.) 14.1999998093 (es) 16.2000007629 (;) ] TJ
0 -1.220600009 TD
0 Tc
[(ww) 11.3999996185 (w.) 18.2999992371 (pr) 15.1000003815 (ed) 17.7000007629 (im) 17 (ed) 11.8999996185 (.o) 14.8999996185 (rg) 21 (\)) -262.299987793 ([) 3.7999999523 (21) 16.5 (].) ] TJ
0.8156999946 -1.2264000177 TD
[(Pa) 14 (rt) 14.3999996185 (i) 11.1999998093 (c) 0 (i) 12.8000001907 (p) 0 (a) 17.7000007629 (nts) -268.299987793 (we) 15.8999996185 (re) -259.799987793 (me) 13.1000003815 (n) -269.5 (a) 0 (n) 15.5 (d) -273.1000061035 (wo) 13.6999998093 (me) 13.1000003815 (n) -269.5 (a) 0 (g) 17.7000007629 (e) 0 (d) -265.799987793 (5) 0 (5) -261.1000061035 (t) 0 (o) -262.8999938965 (8) 0 (0) -266.8999938965 (a) 0 (n) 15.5 (d) -267.299987793 (60) ] TJ
-0.8156999946 -1.2264000177 TD
[(to) -315 (80) -313.200012207 (ye) 14.6999998093 (ar) 17.8999996185 (s) -14.1999998093 (,) -320 (re) 12.1000003815 (sp) 19.2999992371 (ect) 12.6999998093 (iv) 12.1999998093 (el) 18.6000003815 (y.) -312.700012207 (T) 18.1000003815 (h) 0 (e) 10.3000001907 (y) -322.3999938965 (we) 15.8999996185 (re) -311.8999938965 (fr) 18.1000003815 (ee) -315.1000061035 (of) -317.1000061035 (ca) 14.6999998093 (rd) 15.1000003815 (i) 11.1999998093 (o) 0 (v) 17.7000007629 (asc) 12.1000003815 (ul) 14.1999998093 (ar) ] TJ
0 -1.220600009 TD
0.2477000058 Tc
[(d) 263.799987793 (i) 264.700012207 (s) 268.200012207 (e) 260.799987793 (a) 247.6999969482 (s) 275.6000061035 (ea) 260.799987793 (t) 14.3000001907 (b) 264.3999938965 (a) 247.6999969482 (s) 269.799987793 (e) 260.799987793 (l) 270.5 (i) 264.700012207 (n) 261.700012207 (ea) 266.6000061035 (n) 261.700012207 (d) 3.5 (m) 265 (e) 260.799987793 (ta) 266.6000061035 (tl) 264.700012207 (e) 266.6000061035 (a) 247.6999969482 (s) 269.799987793 (t) 2.7999999523 (o) 264.3999938965 (n) 261.700012207 (eo) 264.3999938965 (ft) 268.8999938965 (h) 262.299987793 (e) 0.5 (t) 263.1000061035 (w) 267.8999938965 (of) 266.799987793 (o) 264.3999938965 (l) 264.700012207 (l) 264.700012207 (o) 264.3999938965 (w) 262.1000061035 (i) 264.700012207 (n) 267.5 (g) ] TJ
0 -1.2264000177 TD
0 Tc
[(cr) 17.8999996185 (it) 15.1000003815 (er) 17.8999996185 (ia:) -365.1000061035 (ty) 16.8999996185 (pe) -364.1000061035 (2) -367.799987793 (d) 0 (i) 15.8000001907 (a) 0 (b) 12.5 (e) 0 (t) 16.8999996185 (e) 0 (s) -359.700012207 (m) 0 (e) 13.1000003815 (l) 11.1999998093 (li) 16.7000007629 (tu) 12.6000003815 (s) -367.1000061035 (o) 0 (r) -360.3999938965 (t) 0 (h) 12.6000003815 (e) -368.700012207 (pr) 15.1000003815 (es) 16.2999992371 (en) 15.5 (ce) -361.3999938965 (o) 10.8999996185 (f) -368.5 (th) 12.6000003815 (re) 17.8999996185 (e) ] TJ
T*
[(or) -256.200012207 (m) 11.5 (o) 0 (r) 15.6999998093 (e) -276.1000061035 (co) 18.2000007629 (ro) 15.6999998093 (na) 15.5 (ry) -254 (he) 16.1000003815 (ar) 12.1000003815 (t) -262.299987793 (d) 0 (i) 15.8000001907 (s) 0 (e) 16.2999992371 (ase) -254 (ri) 16 (sk) -254.6999969482 (fa) 14.8999996185 (ct) 16.8999996185 (or) 15.6999998093 (s.) ] TJ
0.8156999946 -1.220600009 TD
[(Pre) -16 (vious) -450.8999938965 (histor) -9.3999996185 (y) -443.8999938965 (o) 0 (f) -444.3999938965 (c) 0 (a) -8.5 (rdiova) -18.1000003815 (scular) -449.1000061035 (disea) -18.3999996185 (se,) -448.299987793 (any) -445.700012207 (se) -18.3999996185 (vere) ] TJ
-0.8156999946 -1.2264000177 TD
[(chronic) -572 (illne) -8.6000003815 (ss) -22.6000003815 (,) -563 (histor) -9.3999996185 (y) -559.5999755859 (o) 0 (f) -565.799987793 (food) -573.5 (allergy,) -572.799987793 (intolera) -10.3999996185 (nce) -567.200012207 (to) ] TJ
T*
[(olive) -450 (oil) -452.5 (or) -447.1000061035 (nut) -13.8999996185 (s) -19.8999996185 (,) -447.299987793 (drug) -451.700012207 (addictio) -14.1999998093 (n) -443 (o) 0 (r) -447.1000061035 (chr) -8.1000003815 (onic) -448.299987793 (alco) -9.5 (holism) ] TJ
0 -1.220600009 TD
[(were) -371.200012207 (ex) 10.3999996185 (clusi) -10.3000001907 (on) -362.700012207 (criteria) -376.1000061035 (in) -362.3999938965 (the) -367.700012207 (PRED) -9 (IMED) -364.700012207 (trial.) -374.200012207 (Subje) -17.1000003815 (ct) -12 (s) ] TJ
0 -1.2264000177 TD
[(were) -423.200012207 (scree) -10.6000003815 (ned) -419.6000061035 (for) -422.200012207 (problema) -12.3999996185 (tic) -423 (use) -420.3999938965 (of) -421.200012207 (alco) -9.5 (hol) -420.299987793 (using) -426.799987793 (the) ] TJ
T*
[(C) -11.3999996185 (A) 0 (G) 12.3000001907 (E) -294.200012207 (qu) 13.3000001907 (es) 16.2999992371 (ti) 15.1000003815 (o) 10.8999996185 (n) 0 (n) 16.3999996185 (a) 0 (i) 12.8000001907 (r) 0 (e) -288.700012207 (\() 0 (a) -289.700012207 (f) 0 (o) 18.3999996185 (u) 0 (r) 36.7000007629 (-) 0 (i) 16.6000003815 (t) 0 (e) 16.8999996185 (m) -300.8999938965 (sc) 16.2999992371 (re) 17.8999996185 (en) 15.5 (in) 13.6999998093 (g) -296.200012207 (t) 0 (o) 14.6999998093 (o) 10.8999996185 (l\)) -291.5 ([) 9.6000003815 (2) 0 (1) 16.5 (]) -297 (an) 15.5 (d) ] TJ
0 -1.220600009 TD
0.0207000002 Tc
[(they) -481 (w) -5.4000000954 (e) 4.9000000954 (re) -481 (not) -484.6000061035 (i) 3 (nclu) -5.1999998093 (ded) -478 (i) -2.7999999523 (n) -480.200012207 (t) 1.3999999762 (he) -481 (trial) -482.8999938965 (i) 3 (f) -480.799987793 (t) 1.3999999762 (h) -5.1999998093 (e) -0.8999999762 (y) -481 (a) 4.9000000954 (nswered) ] TJ
0 -1.2264000177 TD
0 Tc
[(po) 15.5 (si) 14.3999996185 (ti) 20.7999992371 (ve) 14.1000003815 (ly) -253.3000030518 (to) -257.200012207 (at) -255 (l) 11.1999998093 (eas) 12.1000003815 (t) -262.299987793 (t) 0 (w) 12.3999996185 (o) -261 (qu) 13.3000001907 (es) 16.2999992371 (ti) 15.1000003815 (o) 10.8999996185 (n) 0 (s) -254.6999969482 (o) 0 (n) -252.8000030518 (t) 0 (h) 12.6000003815 (i) 11.1999998093 (s) -262.8999938965 (q) 0 (u) 13.3000001907 (e) 0 (s) 16.2999992371 (t) 0 (i) 15.1000003815 (o) 10.8999996185 (nn) 16.3999996185 (ai) 12.8000001907 (re) 17.8999996185 (.) ] TJ
0.8156999946 -1.2264000177 TD
0.0108000003 Tc
[(Participant) -8.5 (s) -454.6000061035 (who) -458.3999938965 (m) -0.8000000119 (et) -459.700012207 (the) -456.200012207 (p) 3.7999999523 (re) -10.8000001907 (vi) 10.8000001907 (o) -7.5 (u) -3.5999999046 (s) -454.6000061035 (i) -1.1000000238 (nclusion) -455.3999938965 (criteri) 10.8000001907 (a) ] TJ
-0.8156999946 -1.220600009 TD
0 Tc
[(\(n) -254.1000061035 (=) -255.8000030518 (7) 0 (,) 12.1999998093 (4) 0 (4) 16.5 (7) 14.1000003815 (\)) -262.299987793 (w) 0 (e) 15.8999996185 (r) 0 (e) -254 (r) 0 (a) 17.8999996185 (n) 0 (d) 12.8000001907 (o) 10.8999996185 (ml) 17 (y) -264.6000061035 (ass) 13.6999998093 (i) 11.1999998093 (g) 0 (n) 12.8000001907 (e) 0 (d) -248.3999938965 (t) 0 (o) -251.3999938965 (t) 0 (h) 12.6000003815 (r) 0 (e) 17.8999996185 (e) -258.799987793 (in) 13.6999998093 (te) 16.8999996185 (r) -24.2000007629 (v) 0 (e) 14.1000003815 (n) 0 (t) 17.7999992371 (i) 0 (o) 16.3999996185 (ns:) ] TJ
0 -1.2264000177 TD
[(Me) 14.5 (di) 15.8000001907 (te) 16.8999996185 (rr) 15.3000001907 (an) 15.5 (ea) 14.6999998093 (n) -408.299987793 (d) 0 (i) 15.8000001907 (e) 0 (t) -411.1000061035 (s) 0 (u) 17.7000007629 (p) 0 (p) 14.8999996185 (l) 11.1999998093 (em) 13.1000003815 (en) 15.5 (te) 16.8999996185 (d) -412 (w) 0 (i) 19.7999992371 (t) 0 (h) -403.8999938965 (e) 0 (x) 16.2000007629 (t) 0 (r) 14.3999996185 (a) -397.6000061035 (v) 12.6000003815 (i) 0 (r) 16 (g) 0 (i) 15.8999996185 (n) -408.299987793 (ol) 16.3999996185 (iv) 18 (e) ] TJ
T*
[(oi) 16.3999996185 (l,) -320.299987793 (Me) 14.5 (di) 15.8000001907 (te) 16.8999996185 (rr) 15.3000001907 (an) 15.5 (ea) 14.6999998093 (n) -327.299987793 (d) 0 (i) 15.8000001907 (e) 0 (t) -335.8999938965 (s) 0 (u) 17.7000007629 (p) 0 (p) 14.8999996185 (l) 11.1999998093 (em) 13.1000003815 (en) 15.5 (te) 16.8999996185 (d) -331 (w) 0 (i) 14 (t) 0 (h) -322.8999938965 (m) 11.5 (ix) 14.3000001907 (ed) -323.6000061035 (nu) 17 (ts) -328.5 (or) ] TJ
0 -1.220600009 TD
0.0109999999 Tc
[(a) -438.700012207 (c) 1 (ontrol) -434.799987793 (g) 4.0999999046 (r) -1.6000000238 (oup.) -436.299987793 (T) 11 (h) 3.0999999046 (ey) -438.700012207 (wer) 4.1999998093 (e) -438.700012207 (annuall) 11 (y) -444.799987793 (inter) -30.5 (v) 0.400000006 (iewed) -435.700012207 (b) -1.2000000477 (y) -432.8999938965 (a) ] TJ
0 -1.2264000177 TD
0 Tc
[(d) -12.8000001907 (i) 0 (e) -16.1000003815 (t) -13.5 (i) -11.8999996185 (c) -10 (ia) -21.8999996185 (n) -9.1000003815 (,) -337.3999938965 (ob) -18.7000007629 (t) -13.5 (a) -10 (i) -11.8999996185 (n) -9.1000003815 (in) -21 (g) -336.700012207 (i) 0 (n) -21 (f) -9.8000001907 (or) -19 (m) -11.6000003815 (a) -10 (t) -13.5 (i) 0 (o) -18.2999992371 (n) -338.8999938965 (a) -10 (b) -12.1999998093 (ou) -20.7999992371 (t) -337.5 (l) 0 (i) -18 (f) -9.8000001907 (e) -10 (s) -14.1999998093 (t) -7.6999998093 (y) -10 (l) -11.8999996185 (e) -10 (,) -337.3999938965 (d) -12.8000001907 (ie) -16.1000003815 (t) -337.5 (a) -15.8000001907 (n) -9.1999998093 (d) ] TJ
T*
0.0107000005 Tc
[(incident) -448.299987793 (di) 10.6999998093 (s) -9.6000003815 (e) 0.6999999881 (a) -10.8999996185 (s) 2.2999999523 (es.) -448.1000061035 (F) -1.5 (urthe) -5.0999999046 (r) -447.299987793 (a) -10.8999996185 (s) 2.2999999523 (pe) -10.8999996185 (ct) -8.6000003815 (s) -448.8999938965 (o) -1.5 (f) -450.3999938965 (t) -2.7999999523 (he) -450.6000061035 (methods) -454.700012207 (a) 0.6999999881 (nd) ] TJ
0 -1.220600009 TD
-0.0182000007 Tc
[(design) -484.3999938965 (of) -485 (the) -485.200012207 (P) 0 (RE) -5.8000001907 (DIME) -5.8000001907 (D) -480.8999938965 (t) -2.7999999523 (rial) -481.299987793 (ha) 12.3000001907 (ve) -485.200012207 (be) -5.0999999046 (en) -484.3999938965 (re) -5.0999999046 (ported) -488 (else) -5.0999999046 (-) ] TJ
0 -1.2264000177 TD
-0.0148999998 Tc
[(wh) 5.4000000954 (er) 7.1999998093 (e) -291 (i) 2.0999999046 (n) -290.200012207 (d) 1.2000000477 (et) 6.3000001907 (ail) -287.1000061035 ([) 0.5 (2) 4.9000000954 (2) -0.8000000119 (,) 6.4000000954 (2) -0.8000000119 (3) 4.9000000954 (]) 0.5 (.) -288.6000061035 (T) 9 (h) 5.4000000954 (e) -291 (Re) 4 (s) 5.5999999046 (e) -1.7999999523 (a) 4 (r) 1.3999999762 (c) 4 (h) -295.3999938965 (a) 4 (n) 4.9000000954 (d) -293.799987793 (E) 3.2999999523 (th) 5.4000000954 (ic) -291 (Commit) 6.3000001907 (te) 4 (e) ] TJ
T*
-0.0174000002 Tc
[(of) -328 (the) -334 (H) 0.5 (ospital) -330.1000061035 (C) 0.1000000015 <6CED6E6963> -328.200012207 (\(B) -17.3999996185 (arcelona) -17.3999996185 (,) -330.1000061035 (Spa) -4.3000001907 (i) -0.400000006 (n\),) -325.799987793 (a) -4.3000001907 (ccredited) -331 (by) -328.200012207 (the) ] TJ
0 -1.220600009 TD
[(Depa) -4.4000000954 (rtme) -4.4000000954 (nt) -372.299987793 (of) -374.3999938965 (He) -4.4000000954 (alth) -373.200012207 (and) -371.6000061035 (H) 0.400000006 (uman) -373.700012207 (Se) -4.4000000954 (r) -30.1000003815 (v) 0.8000000119 (ice) -4.4000000954 (s) -373 (and) -371.6000061035 (r) -1.2000000477 (egula) -4.4000000954 (t) 3.7000000477 (e) -4.4000000954 (d) ] TJ
0 -1.2264000177 TD
-0.0164999999 Tc
[(by) -292.6000061035 (the) -292.6000061035 (F) 0.200000003 (eder) 5.5999999046 (alwide) -292.6000061035 (A) -16.5 (s) 6.3000001907 (s) 4 (u) -1.8999999762 (rance) -292.6000061035 (f) 2.5999999046 (or) -289.3999938965 (the) -286.799987793 (P) -4.0999999046 (r) 5.5999999046 (o) 0.200000003 (te) -16.5 (c) 4 (t) 4.6999998093 (ion) -291.799987793 (o) 0.200000003 (f) -292.3999938965 (H) 1.3999999762 (uman) ] TJ
T*
-0.0178999994 Tc
[(Su) -3.2999999523 (bje) -17.8999996185 (c) 2.5999999046 (t) -17.8999996185 (s) -282.799987793 (of) -293.799987793 (Intern) -3.9000000954 (ational) -295.8999938965 (\() -2.5 (Non) -3.9000000954 (-) -1 (US\)) -291.799987793 (I) -3.0999999046 (nstitu) -3.2999999523 (tions) -292.3999938965 (#) -293.1000061035 (0) -3.7999999523 (0) 1.8999999762 (0) -3.7999999523 (007) -3.7999999523 (38) ] TJ
0 -1.220600009 TD
-0.0168999992 Tc
[(approved) -307.3999938965 (the) -304.6000061035 (s) -2.0999999046 (tudy) -304.6000061035 (protocol) -306.5 (on) -309.5 (16) -303.700012207 (July) -304.6000061035 (2002.) -308 (T) 12.6999998093 (his) -303 (t) -1.5 (rial) -306.5 (ha) -16.8999996185 (s) ] TJ
0 -1.2264000177 TD
[(been) -442.5 (registered) -446.1000061035 (in) -448.299987793 (the) -449.1000061035 (L) 1.3999999762 (ondon) -448.299987793 (C) 0.6999999881 (urrent) -446.8999938965 (Controll) 6 (ed) -446.1000061035 (Trials) ] TJ
25.3094997406 64.8964004517 TD
-0.0181000009 Tc
[(w) -3.7000000477 (i) -1.1000000238 (th) -385.299987793 (th) -3.5 (e) -386.799987793 (n) 1.7000000477 (u) -3.5 (m) -0.8000000119 (ber) -383.6000061035 (I) -3.2999999523 (SRC) -18.1000003815 (T) -5.6999998093 (N) -386.200012207 (3) -4 (573) -4 (96) -4 (39) -385.8999938965 ([24].) -384.3999938965 (A) -4.3000001907 (ll) -382.8999938965 (participan) -4.0999999046 (t) -18.1000003815 (s) ] TJ
0 -1.220600009 TD
-0.0171000008 Tc
[(provided) -267.1000061035 (written) -269.200012207 (i) -0.1000000015 (nformed) -267.1000061035 (c) -4 (onsent.) ] TJ
0.8156999946 -1.2264000177 TD
0 Tc
[(Ou) 14.6000003815 (t) -337.5 (o) 10.8999996185 (f) -333.799987793 (7) 0 (,) 12.1999998093 (4) 0 (4) 16.5 (7) -333 (pa) 17.7000007629 (rt) 14.3999996185 (i) 11.1999998093 (c) 0 (i) 12.8000001907 (p) 0 (a) 17.7000007629 (nts) -7.9000000954 (,) -337.3999938965 (w) 0 (e) -325.3999938965 (e) 0 (x) 22 (c) 0 (l) 18.6000003815 (u) 0 (d) 13.3000001907 (e) 0 (d) -323.6000061035 (1) 0 (5) 16.5 (3) -338.799987793 (pa) 17.7000007629 (rt) 14.3999996185 (i) 11.1999998093 (c) 0 (i) 12.8000001907 (p) 0 (a) 17.7000007629 (nts) ] TJ
-0.8156999946 -1.2264000177 TD
[(wi) 14 (th) -317.200012207 (to) 14.6999998093 (ta) 16.8999996185 (l) -324.299987793 (e) 0 (n) 15.5 (e) 0 (r) 17.8999996185 (g) 0 (y) -317.799987793 (i) 11.1999998093 (nt) 12 (ak) 21.3999996185 (e) -328.200012207 (o) 10.8999996185 (ut) -317.200012207 (of) -317.1000061035 (pr) 15.1000003815 (ed) 17.7000007629 (ef) 14.8999996185 (in) 13.6999998093 (ed) -312.1000061035 (li) 16.7000007629 (mi) 11.1999998093 (ts) -322.700012207 (\(8) 12.1000003815 (00) -313.200012207 (an) 15.5 (d) ] TJ
0 -1.220600009 TD
0.0100999996 Tc
[(4,000) -525.4000244141 (Kcal/da) -5.6999998093 (y) -526.4000244141 (for) -523.200012207 (m) -1.5 (en) -525.5 (a) -5.6999998093 (n) 1 (d) -523.299987793 (5) -4.8000001907 (00) -525.4000244141 (and) -529.0999755859 (3) 1 (,500) -525.4000244141 (Kcal/day) ] TJ
0 -1.2264000177 TD
-0.0208999999 Tc
[(for) -415.299987793 (w) -0.6999999881 (omen\)) -416.200012207 ([) 0.3000000119 (25].) -416.1000061035 (A) -1.2999999523 (n) 4.6999998093 (o) -4.1999998093 (ther) -415.299987793 (1,579) -411.799987793 (subje) -7.8000001907 (c) -2 (t) -20.8999996185 (s) -407.299987793 (who) -414.8999938965 (r) 1.2000000477 (eported) -415.5 (a) -2 (t) ] TJ
T*
-0.0219000001 Tc
[(ba) -21.8999996185 (s) 6 (e) 2.7999999523 (l) -4.9000000954 (i) 0.8999999762 (ne) -263.299987793 (pre) -21.8999996185 (v) 9.6000003815 (alent) -261 (d) 0 (epression,) -260.8999938965 (p) 0 (re) -8.8000001907 (vious) -261.700012207 (h) -1.6000000238 (istory) -263.299987793 (of) -263.1000061035 (depr) -5.5999999046 (ession) ] TJ
0 -1.220600009 TD
0.0109999999 Tc
[(or) -447 (use) -450.200012207 (o) -1.2000000477 (f) -444.299987793 (a) 1 (ntidepr) 4.1999998093 (e) -4.8000001907 (ssant) -442.200012207 (drugs) -442.799987793 (w) -3.5999999046 (er) 4.1999998093 (e) -450.299987793 (a) 1 (lso) -446.700012207 (e) 1 (x) 11 (c) -1.7999999523 (luded) -447.200012207 (\() 3.2000000477 (to) ] TJ
0 -1.2264000177 TD
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[(Statistica) -11 (l) -298.3999938965 (analys) -8 (is) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 684.9636230469 Tm
[(C) 11.6999998093 (o) 16.7000007629 (x) -274.6000061035 (r) 16.2999992371 (e) 13.1000003815 (g) 16.2000007629 (re) 23.7000007629 (s) 14.8000001907 (s) 14.8000001907 (i) 17 (o) 10.8999996185 (n) -269.5 (m) 11.5 (o) 16.7000007629 (de) 23.5 (l) 17 (s) -274.5 (w) 14.3999996185 (e) 13.1000003815 (r) 16.2999992371 (e) -276.1000061035 (u) 14.6000003815 (s) 14.8000001907 (e) 13.1000003815 (d) -273.1000061035 (t) 15.3999996185 (o) -272.5 (as) 16.2999992371 (s) 14.8000001907 (e) 13.1000003815 (s) 14.8000001907 (s) -268.700012207 (th) 24.2000007629 (e) -270.299987793 (r) 0 (e) 23.7000007629 (l) 17 (a) 13.1000003815 (t) 15.3999996185 (i) 11.1999998093 (o) 16.7000007629 (n) 14 (s) 14.8000001907 (h) 14.6000003815 (i) 11.1999998093 (p) ] TJ
0 -1.2264000177 TD
0.0105999997 Tc
[(between) -472.8999938965 (cate) -5.1999998093 (g) 3.7000000477 (ories) -472.200012207 (o) -1.6000000238 (f) -496.700012207 (b) -1.6000000238 (a) -11 (s) 2.2000000477 (eline) -468 (a) -5.1999998093 (l) 10.6000003815 (c) -5.5 (oho) 10.6000003815 (l) -476.299987793 (intake) -468 (and) -465 (t) -2.9000000954 (he) ] TJ
T*
0 Tc
[(s) -8.3999996185 (u) -14.3999996185 (bs) -20.6000003815 (e) -10 (q) -12.8000001907 (u) -8.6000003815 (e) -10 (n) -9.1000003815 (t) -528.4000244141 (in) -21 (c) -10 (i) 0 (d) -18.8999996185 (e) -10 (n) -9.1000003815 (c) -10 (e) -524.9000244141 (o) -12.1999998093 (f) -524.700012207 (d) -12.8000001907 (e) -10 (p) -7 (r) -12.6000003815 (e) -10 (s) -8.3999996185 (s) -14.1999998093 (io) -18.2999992371 (n) -524 (d) -12.8000001907 (u) -8.6000003815 (r) -12.6000003815 (in) -21 (g) -533.4000244141 (f) -9.8000001907 (o) -12.1999998093 (l) 0 (l) -18 (o) -12.1999998093 (w) -8.8000001907 (-) -12 (u) -8.6000003815 (p) -12.8000001907 (.) ] TJ
0 -1.220600009 TD
0.0092000002 Tc
[(Haz) -10.8000001907 (a) -6.5999999046 (rd) -408.5 (rat) -4.3000001907 (i) 9.1999998093 (o) -9.1000003815 (s) -404.1000061035 (\() -4.3000001907 (H) -1.7999999523 (R\)) -403.5 (an) -5.6999998093 (d) -402.799987793 (t) -4.3000001907 (hei) -2.7000000477 (r) -402.6000061035 (95) -5.6999998093 (%) -404.5 (c) -0.8000000119 (o) -3 (n) 0.1000000015 (fi) -2.7000000477 (de) -6.5999999046 (nce) -405.799987793 (i) -2.7000000477 (nter) -32.2999992371 (val) -2.7000000477 (s) ] TJ
0 -1.2264000177 TD
0.0108000003 Tc
[(\(95%) -368.200012207 (CI\)) -373 (w) 2 (ere) -375.200012207 (c) -5 (al) 10.8000001907 (c) -11.1000003815 (u) 2.2000000477 (lated) -372.200012207 (u) 2.2000000477 (si) 10.8000001907 (n) -4.5 (g) -372.200012207 (the) -369.5 (a) 0.8000000119 (bstai) 10.8000001907 (n) -10.1999998093 (ers) -367.799987793 (g) -1.8999999762 (roup) -366.3999938965 (a) -10.8000001907 (s) ] TJ
T*
0.0098999999 Tc
[(the) -457.1000061035 (r) -2.7000000477 (eference) -474.5 (cate) -5.9000000954 (g) 3 (ory) -5.9000000954 (.) -454.700012207 (Entry) -457.1000061035 (t) -3.5999999046 (i) 9.8999996185 (m) -7.8000001907 (e) -462.8999938965 (w) 1.1000000238 (a) -11.6999998093 (s) -461.299987793 (de) -5.9000000954 (fi) 9.8999996185 (n) -11.1000003815 (e) -0.1000000015 (d) -459.8999938965 (a) -11.6999998093 (s) -455.5 (t) -3.5999999046 (he) ] TJ
0 -1.220600009 TD
0.0103000002 Tc
[(date) -294.799987793 (at) -298.299987793 (re) -11.3000001907 (c) -5.5 (r) 3.5 (uitment.) -298.1000061035 (Exit) -292.5 (ti) 10.3000001907 (m) -7.4000000954 (e) -294.799987793 (wa) -11.3000001907 (s) -293.1000061035 (d) -2.5 (efined) -291.700012207 (a) -11.3000001907 (s) -298.8999938965 (the) -300.5 (d) 3.2999999523 (ate) -294.799987793 (a) 0.3000000119 (t) ] TJ
0 -1.2264000177 TD
0 Tc
[(di) 15.8000001907 (ag) 17.7000007629 (no) 13.3000001907 (si) 14.3999996185 (s) -274.5 (o) 0 (f) -276.6000061035 (d) 0 (e) 17.7000007629 (p) 0 (r) 15.1000003815 (e) 0 (s) 16.2999992371 (s) 0 (i) 14.3999996185 (o) 10.8999996185 (n) -281 (f) 0 (o) 12.6999998093 (r) -278.700012207 (cas) 12.1000003815 (es) -267.200012207 (an) 15.5 (d,) -275 (fo) 18.3999996185 (r) -284.5 (p) 0 (a) 17.7000007629 (r) 0 (t) 14.3999996185 (i) 11.1999998093 (ci) 12.8000001907 (pa) 17.7000007629 (nts) -274 (wh) 11.6000003815 (o) ] TJ
T*
[(di) 15.8000001907 (d) -348.299987793 (n) 0 (o) 13.3000001907 (t) -349.1000061035 (dev) 12.8999996185 (el) 18.6000003815 (op) -343.200012207 (de) 11.8999996185 (pr) 20.8999996185 (es) 16.2999992371 (si) 14.3999996185 (on) 13.3000001907 (,) -348.8999938965 (a) 0 (s) -353.8999938965 (t) 0 (h) 18.3999996185 (e) -351.299987793 (da) 17.7000007629 (te) -347.5 (wh) 17.3999996185 (en) -343.1000061035 (co) 18.2000007629 (mpl) 21.5 (et) 16.8999996185 (in) 13.6999998093 (g) ] TJ
0 -1.220600009 TD
0.0201999992 Tc
[(the) -365.799987793 (l) 2.5 (a) -13 (s) 0.200000003 (t) -363.6000061035 (i) 2.5 (nter) -32.9000015259 (view,) -363.3999938965 (1) -364.8999938965 (De) -13 (cember) -362.6000061035 (2010) 5.3000001907 (,) -363.3999938965 (o) -3.5999999046 (r) -362.6000061035 (d) 1.6000000238 (ate) -365.799987793 (a) 4.4000000954 (t) -363.6000061035 (d) -4.1999998093 (eath,) ] TJ
0 -1.2264000177 TD
-0.0168999992 Tc
[(whiche) -16.8999996185 (ver) -260.8999938965 (c) -3.7999999523 (ame) -264.1000061035 (f) 2.2000000477 (irst.) -261.700012207 (W) -1.8999999762 (e) -264.1000061035 (a) 2 (djusted) -266.8999938965 (t) 4.3000001907 (he) -264.1000061035 (multivar) 5.1999998093 (iable) -258.299987793 (m) 0.400000006 (odels) ] TJ
T*
-0.0175000001 Tc
[(for) -383 (t) 3.7000000477 (he) -380.3999938965 (following) -383.1000061035 (pote) -4.4000000954 (ntial) -382.299987793 (c) 1.3999999762 (on) -3.5 (founders) -17.5 (:) -374.799987793 (a) 1.3999999762 (ge,) -383.799987793 (s) 3 (e) -4.4000000954 (x) -17.5 (,) -369.200012207 (s) -2.7000000477 (mokin) -3.5 (g) ] TJ
0 -1.220600009 TD
-0.0162000004 Tc
[(st) 5 (at) 5 (us) -585.700012207 (\(non-s) 4.3000001907 (mokers) -16.2000007629 (,) -587.5999755859 (e) -3.0999999046 (x) 4.1999998093 (-) 0.6999999881 (smokers) -585.700012207 (a) 2.7000000477 (nd) -584.4000244141 (current) -596.700012207 (smokers) 4.3000001907 (\)) -0.8000000119 (,) ] TJ
0 -1.2264000177 TD
0 Tc
[(ph) 13.3000001907 (ys) 16.2999992371 (i) 11.1999998093 (c) 0 (a) 14.6999998093 (l) -399.5 (ac) 14.6999998093 (ti) 15.1000003815 (vi) 18 (ty) -393.799987793 (\(M) 11 (E) 12.3999996185 (T) 58.5999984741 (-m) 16.7999992371 (in) 13.6999998093 (/) 11.1000003815 (d) 0 (\)) 14.1999998093 (,) -401 (to) 14.6999998093 (ta) 16.8999996185 (l) -399.5 (e) 0 (n) 15.5 (e) 0 (r) 12.1000003815 (g) 0 (y) -393 (i) 11.1999998093 (nt) 12 (a) 13.1000003815 (k) 0 (e) -395.1000061035 (\() 0 (K) 16.1000003815 (c) 0 (a) 14.6999998093 (l) 0 (/) ] TJ
T*
[(da) 17.7000007629 (y\)) 11.1999998093 (,) -534.0999755859 (bas) 9.8999996185 (el) 18.6000003815 (in) 13.6999998093 (e) -536.5 (b) 10.8999996185 (od) 15.5 (y) -536.5 (mas) 10.5 (s) -534.799987793 (i) 0 (n) 13.6999998093 (d) 0 (e) 17.7000007629 (x) -540.700012207 (\(k) 17.8999996185 (g/) 15.6999998093 (m) ] TJ
7.3499999046 0 0 6.5324001312 219.6849975586 521.2911987305 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 223.2566986084 516.9259033203 Tm
[(\),) -530.200012207 (m) 11.5 (a) 0 (r) 12.1000003815 (i) 11.1999998093 (ta) 11.1999998093 (l) -532.5 (s) 0 (t) 12.8000001907 (a) 0 (t) 16.8999996185 (u) 0 (s) ] TJ
-16.9964008331 -1.220600009 TD
-0.0141000003 Tc
[(\(married) -287.200012207 (or) -287 (not\),) -287.799987793 (inter) -32.5 (v) -1.5 (ention) -283.6000061035 (g) -14.1000003815 (r) 12.6000003815 (oup) -287.200012207 (\() 1.2999999523 (Medit) -14.1000003815 (e) 8.6000003815 (rranean) -283.6000061035 (d) -14.1000003815 (i) 13.3000001907 (et) -288 (+) ] TJ
0 -1.2264000177 TD
[(virg) -14.1000003815 (i) 13.3000001907 (n) -445.6000061035 (oliv) 4.1999998093 (e) -446.3999938965 (o) -3.2000000477 (il,) -444 (M) -1.1000000238 (e) 4.8000001907 (d) -14.1000003815 (i) 13.3000001907 (t) 1.2999999523 (er) -14.1000003815 (r) 12.8000001907 (a) -1 (nean) -445.6000061035 (diet) -444.200012207 (+) -449.299987793 (n) -0.1000000015 (ut) -14.1000003815 (s) -14.1000003815 (,) -448.6000061035 (low) -445.200012207 (f) -0.8000000119 (at) -444.200012207 (diet) -14.1000003815 (\)) 10.8999996185 (,) ] TJ
T*
-0.0138999997 Tc
[(re) -13.8999996185 (cruitin) 5.9000000954 (g) -547.299987793 (center) -547.0999755859 (\() 1.5 (14) -543.5999755859 (center) -13.8999996185 (s) 11.3999996185 (\),) -542.200012207 (ed) -13.8999996185 (u) 11 (cational) -546.4000244141 (l) 3.0999999046 (e) -13.8999996185 (v) 0.200000003 (e) 5 (l) -546.4000244141 (\() -13.8999996185 (i) 12.6999998093 (n) -543.700012207 (f) -0.6000000238 (iv) 4.4000000954 (e) ] TJ
0 -1.220600009 TD
0.0208999999 Tc
[(categories) -456.1000061035 (f) -0.5 (rom) -465.1000061035 (i) 3.2000000477 (lliterate) -463.5 (t) ] TJ
11.7725000381 0 TD
0.0200999994 Tc
[(o) -466.5 (u) 0 (niversi) -3.4000000954 (t) 0.8000000119 (y) -464.299987793 (g) 1.6000000238 (radu) -5.8000001907 (ate\),) -461.8999938965 (a) -1.5 (nd) ] TJ
-11.7725000381 -1.2264000177 TD
0.0219999999 Tc
[(numb) 4 (er) -291.3999938965 (of) -288.6000061035 (per) 3.5999999046 (s) -3.7000000477 (o) 4 (n) 1.2999999523 (s) -293 (l) 4.3000001907 (iv) 5.5999999046 (ing) -291.5 (a) 6.1999998093 (t) -292.3999938965 (h) 1.8999999762 (ome) -288.799987793 (\() 2.7000000477 (li) 4.3000001907 (vi) 4.3000001907 (ng) -291.5 (alo) 4 (n) 1.2999999523 (e) -288.799987793 (o) -1.7999999523 (r) -291.3999938965 (n) 1.2999999523 (o) 4 (t) -3.0999999046 (\).) ] TJ
T*
0.0211999994 Tc
[(We) -359.1000061035 (e) -6.1999998093 (v) -1 (alua) 5.4000000954 (ted) -350.299987793 (t) -3.9000000954 (he) -353.299987793 (interaction) -352.3999938965 (b) -2.5999999046 (etween) -352.3999938965 (sex) -357.6000061035 (a) -0.400000006 (nd) -350.299987793 (alcohol) ] TJ
0 -1.220600009 TD
0 Tc
[(in) 13.6999998093 (ta) 16.8999996185 (ke) -453 (o) 10.8999996185 (n) -460.3999938965 (th) 12.6000003815 (e) -461.200012207 (dev) 12.8999996185 (el) 18.6000003815 (op) 15.5 (me) 13.1000003815 (nt) -450.799987793 (of) -455.8999938965 (de) 17.7000007629 (pr) 15.1000003815 (es) 16.2999992371 (si) 14.3999996185 (o) 10.8999996185 (n) -460.3999938965 (by) -456.1000061035 (ca) 14.6999998093 (l) 11.1999998093 (c) 0 (u) 10.3000001907 (l) 11.1999998093 (at) 16.8999996185 (in) 13.6999998093 (g) ] TJ
0 -1.2264000177 TD
[(th) 12.6000003815 (e) -345.5 (l) 0 (i) 16.7000007629 (k) 0 (e) 15.6000003815 (l) 0 (i) 16.7000007629 (h) 0 (o) 13.8999996185 (o) 0 (d) -343.200012207 (r) 0 (a) 17.8999996185 (t) 0 (i) 15.1000003815 (o) -347.799987793 (te) 11.1999998093 (st) -328.5 (be) 12.5 (tw) 18.2000007629 (ee) 14.6999998093 (n) -350.5 (t) 0 (h) 12.6000003815 (e) -345.5 (fu) 16.2999992371 (ll) 16.7000007629 (y) -351.299987793 (a) 0 (d) 17.7000007629 (j) 0 (u) 15.8000001907 (s) 0 (t) 12.8000001907 (e) 0 (d) -341 (m) 0 (o) 16.6000003815 (d) 0 (e) 11.8999996185 (l) ] TJ
T*
[(an) 15.5 (d) -313.6000061035 (t) 0 (h) 12.6000003815 (e) -316.6000061035 (sa) 16.2999992371 (me) -310.8999938965 (m) 11.5 (o) 0 (d) 15.5 (e) 0 (l) -311.200012207 (a) 0 (d) 17.7000007629 (d) 0 (i) 15.8000001907 (n) 0 (g) -305.299987793 (t) 0 (h) 12.6000003815 (e) -316.6000061035 (i) 11.1999998093 (n) 0 (t) 12 (e) 0 (r) 17.8999996185 (a) 0 (c) 14.6999998093 (t) 0 (i) 15.1000003815 (o) 10.8999996185 (n) -315.799987793 (p) 0 (r) 15.1000003815 (o) 0 (d) 15.5 (u) 0 (c) 16.1000003815 (t) 27 (-t) 14.8999996185 (er) 17.8999996185 (m.) ] TJ
0 -1.220600009 TD
[(To) -266.1000061035 (ta) 11.1999998093 (ke) -262.1000061035 (ad) 11.8999996185 (v) 12.6000003815 (a) 0 (n) 15.5 (t) 0 (a) 11.1999998093 (g) 0 (e) -265.700012207 (o) 10.8999996185 (f) -275.8999938965 (t) 0 (h) 12.6000003815 (e) -270.299987793 (ye) 14.6999998093 (ar) 12.1000003815 (l) 11.1999998093 (y) -276.1000061035 (re) 17.8999996185 (pe) 11.8999996185 (a) 13.1000003815 (t) 0 (e) 11.1999998093 (d) -273.1000061035 (me) 13.1000003815 (asu) 13.5 (re) 17.8999996185 (me) 13.1000003815 (nts) -268.299987793 (o) 10.8999996185 (f) ] TJ
0 -1.2264000177 TD
0.0108000003 Tc
[(di) 10.8000001907 (e) -5.3000001907 (t) -14.3000001907 (,) -465.3999938965 (w) -3.7999999523 (e) -467.799987793 (u) -3.5999999046 (pdate) -5 (d) -464.799987793 (the) -479.3999938965 (c) -5 (al) 10.8000001907 (c) -11.1000003815 (u) 2.2000000477 (lation) -466.8999938965 (of) -467.6000061035 (alcohol) -469.700012207 (i) -1.1000000238 (nta) -5 (k) 1.7000000477 (e) -467.799987793 (f) 1 (or) ] TJ
T*
0.0103000002 Tc
[(parti) 10.3000001907 (c) -11.6000003815 (i) 10.3000001907 (p) -8.6000003815 (ant) -14.8000001907 (s) -287.299987793 (e) -11.3000001907 (v) -0.3000000119 (ery) -289 (y) -5.5 (ear) -285.799987793 (f) -5.3000001907 (r) 3.5 (om) -290.6000061035 (b) 10.3000001907 (a) -17.7000007629 (seli) 10.3000001907 (n) -5 (e) -294.799987793 (to) -291.200012207 (the) -289 (i) 10.3000001907 (n) -10.6999998093 (c) 0.3000000119 (idenc) -5.5 (e) -289 (o) 10.3000001907 (f) ] TJ
0 -1.220600009 TD
0.0109000001 Tc
[(depressi) 10.8999996185 (o) -7.4000000954 (n) -380.1000061035 (fro) 10.8999996185 (m) -389 (the) -380.8999938965 (r) 4.0999999046 (epeated) -377.8999938965 (FFQs.) -378.5 (To) -383.1000061035 (update) -380.8999938965 (alcohol) ] TJ
0 -1.2264000177 TD
0.0105999997 Tc
[(intake) -259.700012207 (wi) 10.6000003815 (t) -9 (h) -264.1000061035 (all) -261.6000061035 (a) 10.6000003815 (vailabl) 10.6000003815 (e) -271.6000061035 (l) -1.2999999523 (o) 10.6000003815 (n) -10.8000001907 (gitudinal) -267.3999938965 (d) 3.5999999046 (ata) -22.6000003815 (,) -263.1000061035 (and) -262.5 (t) -2.9000000954 (o) -261.8999938965 (a) 0.6000000238 (nalyze) ] TJ
T*
[(the) -433.3999938965 (a) -11.1000003815 (ssociati) 10.5 (o) -7.8000001907 (n) -432.5 (b) -1.7000000477 (etween) -432.5 (alcohol) -429.5 (i) -1.3999999762 (nta) -5.3000001907 (k) 1.3999999762 (e) -433.3999938965 (a) 0.5 (nd) -430.3999938965 (depressi) 10.5 (o) -7.8000001907 (n) ] TJ
0 -1.220600009 TD
0.0109999999 Tc
[(at) -448 (all) -440.6000061035 (t) -2.5 (im) 11 (e) -10.6000003815 (-) 11 (p) -8 (o) -1.2000000477 (i) 11 (n) -10 (t) -8.3000001907 (s) -442.799987793 (si) 11 (m) -6.6999998093 (u) -3.4000000954 (l) 11 (t) -8.6000003815 (aneousl) 11 (y) -10.8999996185 (,) -442.1000061035 (w) -3.5999999046 (e) -444.5 (u) 2.4000000954 (sed) -441.5 (g) -1.7000000477 (eneralized) ] TJ
0 -1.2264000177 TD
[(estimating) -377.8999938965 (equati) 10.8999996185 (o) -7.4000000954 (n) 1.7999999523 (s) -379.299987793 (\() -2.5999999046 (GEE\)) -378.700012207 (wi) 10.8999996185 (t) -8.6999998093 (h) -373.700012207 (Stata) -375.1000061035 (12.0) -374.200012207 (\() -2.5999999046 (Sta) -4.9000000954 (t) 3.2000000477 (aCorp,) ] TJ
T*
0.3176999986 Tc
[(C) 306.299987793 (o) 305.5 (l) 317.700012207 (l) 299.700012207 (e) 307.700012207 (g) 305 (eS) 307 (t) 304.200012207 (a) 307.700012207 (t) 310 (i) 305.799987793 (o) 305.5 (n) 308.6000061035 (,) 55.5 (T) 301.1000061035 (X) 310.5 (,) -2.2999999523 (U) 306.200012207 (S) 307 (A) 308.3999938965 (\)) 310 (.W) 303.700012207 (ea) 296.1000061035 (s) 309.299987793 (s) 303.5 (u) 309.1000061035 (m) 306.1000061035 (e) 307.700012207 (d) -1.7000000477 (ab) 305.5 (i) 305.799987793 (n) 308.6000061035 (o) 305.5 (m) 317.700012207 (i) 300 (a) 307.700012207 (ld) 304.8999938965 (i) 317.700012207 (s) 285.799987793 (-) ] TJ
0 -1.220600009 TD
0.0116999997 Tc
[(tr) 4.9000000954 (ib) 11.6999998093 (u) -9.1000003815 (t) 4 (ion) -298.299987793 (w) -2.9000000954 (i) 11.6999998093 (t) -7.9000000954 (h) -297.700012207 (l) -0.200000003 (ogit) -302.700012207 (mo) 11.6999998093 (d) -7.5 (e) 1.7000000477 (ls) -297.5 (and) -296.1000061035 (t) -1.7999999523 (he) -304.8999938965 (unstr) 4.9000000954 (u) -2.7000000477 (ctur) 4.9000000954 (ed) -296.1000061035 (matr) 4.9000000954 (ix) ] TJ
0 -1.2264000177 TD
0.0104 Tc
[(a) -11.1999998093 (s) -455 (the) -456.6000061035 (w) -4.1999998093 (o) 10.3999996185 (r) -8.6000003815 (king) -453.6000061035 (c) -5.4000000954 (o) 10.3999996185 (r) -8.6000003815 (r) 3.5999999046 (e) -5.4000000954 (l) 10.3999996185 (a) -5.6999998093 (t) -3.0999999046 (io) 10.3999996185 (n) -462.200012207 (s) -3.7999999523 (tructure) -456.6000061035 ([27) -4.5 (]) 2.7000000477 (.) -460 (W) 2.2000000477 (e) -456.6000061035 (d) -2.4000000954 (efined) ] TJ
T*
0.0105999997 Tc
[(the) -520.0999755859 (c) 0.6000000238 (oho) 10.6000003815 (r) -8.3999996185 (t) -512 (r) 3.7999999523 (isk) -513.299987793 (a) -11 (s) -506.8999938965 (p) -2.2000000477 (articipant) -8.6999998093 (s) -512.5999755859 (w) 1.7999999523 (ho) -516.5 (remained) -511.299987793 (free) -514.299987793 (o) 10.6000003815 (f) ] TJ
0 -1.220600009 TD
0.0111999996 Tc
[(depressi) 11.1999998093 (o) -7.0999999046 (n) -350.799987793 (at) -355.200012207 (the) -351.700012207 (b) 11.1999998093 (e) -11 (g) 4.3000001907 (inning) -348.6000061035 (of) -351.5 (eac) -4.5999999046 (h) -350.299987793 (t) 3.5 (wo-) 11.1999998093 (y) -5.0999999046 (e) -4.5999999046 (a) 1.2000000477 (r) -348.5 (f) 1.3999999762 (oll) 11.1999998093 (o) -7.0999999046 (w-) 11.1999998093 (u) -9.3999996185 (p) ] TJ
0 -1.2264000177 TD
0.0107000005 Tc
[(period.) -338.200012207 (P) 0 (a) -5.0999999046 (r) 3.9000000954 (ti) 10.6999998093 (c) -5.4000000954 (i) -1.2000000477 (pant) -8.6000003815 (s) -339 (w) -3.9000000954 (ho) -337.1000061035 (had) -337.6000061035 (b) -1.5 (een) -339.799987793 (cla) -10.8999996185 (s) 2.2999999523 (si) 10.6999998093 (f) -5.1999998093 (i) -1.2000000477 (ed) -337.6000061035 (a) -10.8999996185 (s) -339 (incident) ] TJ
T*
0.0103000002 Tc
[(ca) -11.3000001907 (se) -5.5 (s) -379.8999938965 (w) -4.3000001907 (ere) -381.5 (e) 0.3000000119 (x) 10.3000001907 (c) -2.5 (luded) -384.299987793 (f) 0.5 (rom) -388.8999938965 (s) 1.8999999762 (ubse) -5.5 (quent) -385 (f) 0.5 (ol) 10.3000001907 (l) -7.6999998093 (o) -1.8999999762 (w-up.) -384.8999938965 (T) 10.3000001907 (hen,) ] TJ
0 -1.220600009 TD
0 Tc
[(o) -12.1999998093 (n) -9.1000003815 (l) -11.8999996185 (y) -287.700012207 (t) -13.5 (h) -8.6000003815 (e) -293.5 (f) -9.8000001907 (i) -11.8999996185 (r) -6.8000001907 (s) -14.1999998093 (t) -291.200012207 (in) -21 (c) -10 (i) 0 (d) -18.8999996185 (e) -10 (n) -9.1000003815 (t) -297 (c) -10 (a) -21.6000003815 (s) -8.3999996185 (e) -293.5 (of) -299.700012207 (d) -12.8000001907 (e) -10 (p) -7 (r) -12.6000003815 (e) -10 (s) -8.3999996185 (s) -14.1999998093 (i) 0 (o) -18.2999992371 (n) -292.6000061035 (w) -8.8000001907 (a) -21.6000003815 (s) -291.799987793 (c) -15.8000001907 (on) -15.6000003815 (s) -14.1999998093 (i) -11.8999996185 (d) -7 (e) -10 (r) -12.6000003815 (e) -10 (d) ] TJ
0 -1.2264000177 TD
0.0092000002 Tc
[(a) -12.3999996185 (s) -386.799987793 (o) 9.1999998093 (u) -11.6000003815 (tcome.) -386 (In) -387.5 (th) -5.1999998093 (e) -382.6000061035 (a) -0.8000000119 (na) -6.5999999046 (l) 9.1999998093 (y) -6.9000000954 (s) -5 (i) 9.1999998093 (s) -392.8999938965 (o) -3 (f) -382.3999938965 (r) -3.4000000954 (epe) -6.5999999046 (a) -0.8000000119 (ted) -385.3999938965 (m) -2.4000000954 (ea) -12.3999996185 (s) -5 (u) 0.6000000238 (re) -6.5999999046 (ment) -10.1000003815 (s) -22.2999992371 (,) ] TJ
0 -1.220600009 TD
0.0115999999 Tc
[(to) -544.4000244141 (allow) -546.799987793 (f) 1.7999999523 (or) -544.799987793 (a) -559.5999755859 (s) 3.2000000477 (ufficiently) -548 (l) -0.3000000119 (ong) -556.5 (f) 1.7999999523 (oll) 11.6000003815 (o) -6.6999998093 (w-) 11.6000003815 (u) -9 (p) -545 (per) 4.8000001907 (i) -0.3000000119 (od) 4.5999999046 (,) -551.4000244141 (w) 2.7999999523 (e) ] TJ
0 -1.2264000177 TD
0.0103000002 Tc
[(modeled) -395.8999938965 (t) -3.2000000477 (he) -398.8999938965 (incidence) -393.1000061035 (o) -1.8999999762 (f) -398.700012207 (d) -2.5 (epressi) 10.3000001907 (o) -8 (n) -398 (i) 10.3000001907 (n) -404.1000061035 (r) -2.2999999523 (elation) -392.200012207 (t) -3.2000000477 (o) -395.299987793 (t) -3.2000000477 (he) ] TJ
T*
0 Tc
[(c) -10 (u) -14.3999996185 (mu) -20.2000007629 (la) -21.8999996185 (t) -7.6999998093 (i) -11.8999996185 (v) -10.6000003815 (e) -623.200012207 (av) -14.8000001907 (e) -10 (r) -6.8000001907 (a) -15.8000001907 (g) -6.9000000954 (e) -629 (a) -10 (l) -11.8999996185 (c) -10 (oh) -20.7999992371 (o) -12.1999998093 (l) -625.0999755859 (in) -21 (t) -7.6999998093 (a) -10 (k) -9.1000003815 (e) -629 (f) -9.8000001907 (r) -12.6000003815 (o) -12.1999998093 (m) -624.799987793 (a) -10 (l) -11.8999996185 (l) -625.0999755859 (a) 0 (v) -9 (a) -10 (i) -11.8999996185 (l) -11.8999996185 (a) -10 (b) -12.1999998093 (l) 0 (e) ] TJ
0 -1.220600009 TD
0.0109000001 Tc
[(di) 10.8999996185 (e) -5.1999998093 (t) -2.5999999046 (ary) -386.700012207 (q) -1.8999999762 (ue) -4.9000000954 (stionnaires) -390.8999938965 (up) -389.5 (to) -388.8999938965 (the) -392.5 (s) 2.5 (tart) -390.200012207 (of) -386.5 (e) -4.9000000954 (ach) -391.1000061035 (two-) 10.8999996185 (y) -11.1000003815 (ear) ] TJ
0 -1.2264000177 TD
0.0115999999 Tc
[(foll) 11.6000003815 (o) -6.6999998093 (w) 2.7999999523 (-up) -406.1000061035 (i) -0.3000000119 (nter) -29.8999996185 (val,) -406.799987793 (but) -412.700012207 (w) -3 (e) -409.200012207 (e) 1.6000000238 (x) 11.6000003815 (c) -1.2000000477 (l) 11.6000003815 (u) -8.8999996185 (ded) -406.1000061035 (cases) -407.5 (occur) 4.8000001907 (r) -1 (ing) -411.8999938965 (i) 11.6000003815 (n) ] TJ
T*
0.0102000004 Tc
[(the) -352.700012207 (f) 0.400000006 (irst) -356.200012207 (year) -355.299987793 (o) 10.1999998093 (f) -359 (that) -356.200012207 (perio) 10.1999998093 (d) -361.8999938965 (and) -349.700012207 (t) -3.2999999523 (oo) 10.1999998093 (k) -358.200012207 (i) -1.7000000477 (nto) -349.1000061035 (a) -5.5999999046 (ccount) -356.200012207 (o) 10.1999998093 (n) -11.1999998093 (l) 10.1999998093 (y) ] TJ
0 -1.220600009 TD
0.0105999997 Tc
[(new) -397.299987793 (c) 0.6000000238 (a) -11 (s) 2.2000000477 (es) -391.200012207 (occurri) 10.6000003815 (n) -10.3999996185 (g) -389.700012207 (a) 0.6000000238 (fter) -389.6000061035 (one) -392.799987793 (year.) -390.3999938965 (For) -389.6000061035 (exa) -5.1999998093 (m) -1 (ple,) -390.3999938965 (for) -389.6000061035 (a) ] TJ
0 -1.2264000177 TD
0 Tc
[(pa) 17.7000007629 (rt) 14.3999996185 (ic) 12.8000001907 (i) 11.1999998093 (p) 0 (a) 17.7000007629 (n) 0 (t) -369.799987793 (rec) 13.6000003815 (ru) 13.5 (i) 11.1999998093 (t) 0 (e) 11.1999998093 (d) -377.200012207 (i) 11.1999998093 (n) -373.6000061035 (20) 16.5 (05) -371.1000061035 (th) 18.3999996185 (e) -380.299987793 (i) 11.1999998093 (nc) 15.5 (id) 15.8000001907 (en) 15.5 (ce) -372.8999938965 (o) 10.8999996185 (f) -380.1000061035 (de) 17.7000007629 (pr) 15.1000003815 (es) 16.2999992371 (si) 14.3999996185 (o) 10.8999996185 (n) ] TJ
T*
[(fr) 18.1000003815 (om) -301.5 (20) 16.5 (07) -301.6000061035 (th) 18.3999996185 (ro) 15.6999998093 (ug) 13.3999996185 (h) -309.3999938965 (2) 0 (0) 16.5 (0) 0 (8) -295.8999938965 (was) -304.8999938965 (re) 17.8999996185 (la) 12.8000001907 (te) 16.8999996185 (d) -307.799987793 (t) 0 (o) -297.700012207 (t) 0 (h) 12.6000003815 (e) -305 (al) 12.8000001907 (co) 12.5 (ho) 19.7000007629 (l) -306.8999938965 (i) 0 (n) 13.6999998093 (t) 0 (a) 16.8999996185 (k) 0 (e) ] TJ
0 -1.220600009 TD
[(re) 17.8999996185 (po) 15.5 (rt) 14.3999996185 (ed) -300.5 (on) -304.799987793 (th) 18.3999996185 (e) -310.799987793 (2) 0 (0) 16.5 (0) 0 (5) -301.6000061035 (a) 0 (n) 15.5 (d) -307.799987793 (20) 16.5 (06) -301.6000061035 (qu) 13.3000001907 (es) 16.2999992371 (ti) 15.1000003815 (o) 10.8999996185 (n) 0 (n) 16.3999996185 (a) 0 (i) 12.8000001907 (r) 0 (e) 17.8999996185 (s) 0 (.) -305.299987793 (T) 18.1000003815 (he) 16.1000003815 (re) 17.8999996185 (fo) 12.6999998093 (re) 17.8999996185 (,) ] TJ
0 -1.2264000177 TD
0.0164000001 Tc
[(we) -358.1000061035 (a) -11 (s) 2.2000000477 (sumed,) -349.8999938965 (a) -5.1999998093 (n) -351.3999938965 (induction) -357.200012207 (p) 3.5999999046 (eriod) -349.299987793 (l) -1.2999999523 (onger) -349.1000061035 (t) -2.9000000954 (ha) -5.1999998093 (n) -351.3999938965 (o) -1.6000000238 (ne) -352.299987793 (ye) -5.1999998093 (ar) ] TJ
T*
0.0161000006 Tc
[(but) -408.200012207 (n) 1.2000000477 (ot) -408.200012207 (longer) -407.200012207 (than) -409.6000061035 (two) -406.8999938965 (yea) -5.5 (rs) -408.799987793 (and) -407.3999938965 (a) 0.3000000119 (lcohol) -406.5 (intake) -410.3999938965 (wa) -11.3000001907 (s) ] TJ
25.3094997406 64.8964004517 TD
0 Tc
[(co) 12.5 (ns) 17.2000007629 (i) 11.1999998093 (d) 0 (e) 11.8999996185 (r) 0 (e) 17.8999996185 (d) -267.299987793 (as) -267.200012207 (th) 18.3999996185 (e) -281.8999938965 (c) 13.1000003815 (um) 14.5 (ul) 14.1999998093 (at) 16.8999996185 (iv) 12.1999998093 (e) -264.6000061035 (a) 18.8999996185 (ve) 14.1000003815 (ra) 17.8999996185 (ge) -259.8999938965 (o) 10.8999996185 (f) -270.1000061035 (al) 18.6000003815 (l) -266.3999938965 (a) 18.8999996185 (va) 14.1000003815 (i) 11.1999998093 (l) 0 (a) 12.8000001907 (b) 10.8999996185 (le) -259.1000061035 (FF) 16 (Qs) -8.3999996185 (,) ] TJ
0 -1.220600009 TD
[(fr) 18.1000003815 (om) -278.3999938965 (bas) 9.8999996185 (el) 18.6000003815 (in) 13.6999998093 (e) -281.8999938965 (t) 0 (o) -280.299987793 (t) 0 (h) 18.3999996185 (e) -287.700012207 (b) 10.8999996185 (e) 0 (g) 12 (i) 11.1999998093 (nn) 16.3999996185 (in) 13.6999998093 (g) -278.799987793 (o) 0 (f) -276.6000061035 (e) 0 (a) 14.6999998093 (c) 0 (h) -278.8999938965 (t) 0 (w) 12.3999996185 (o) 10.8999996185 (-y) 12.6999998093 (ea) 14.6999998093 (r) -284.5 (f) 0 (o) 18.5 (l) 0 (l) 16.7000007629 (o) 0 (w) 13.6999998093 (-) 0 (u) 14.1000003815 (p) ] TJ
0 -1.2264000177 TD
[(pe) 17.7000007629 (ri) 16 (od) 15.5 (.) -429.8999938965 (S) 12.5 (eve) 9.8999996185 (ra) 17.8999996185 (l) -428.3999938965 (s) 0 (e) 16.2999992371 (n) 0 (s) 17.2000007629 (i) 0 (t) 15.1000003815 (i) 11.1999998093 (vi) 12.1999998093 (ty) -416.8999938965 (an) 15.5 (al) 12.8000001907 (y) 13.1000003815 (s) 0 (e) 10.5 (s) -424.8999938965 (we) 15.8999996185 (re) -427.6000061035 (co) 12.5 (nd) 18.5 (uc) 16.1000003815 (te) 11.1999998093 (d) -423.5 (r) 0 (e) 17.8999996185 (f) 0 (i) 13 (t) 27 (-) ] TJ
T*
[(ti) 15.1000003815 (ng) -421.1000061035 (Co) 16.7999992371 (x) -430.799987793 (r) 0 (e) 17.8999996185 (g) 0 (r) 15.1999998093 (e) 0 (s) 16.2999992371 (s) 0 (i) 14.3999996185 (o) 0 (n) -420.5 (a) 0 (n) 15.5 (a) 0 (l) 12.8000001907 (y) 0 (s) 16.2999992371 (e) 0 (s) -423.3999938965 (a) 0 (f) 14.8999996185 (t) 0 (e) 16.8999996185 (r) -429.1000061035 (a\)) -422.700012207 (es) 16.2999992371 (ta) 16.8999996185 (bl) 10.6000003815 (i) 11.1999998093 (s) 0 (h) 17.7000007629 (i) 0 (n) 13.6999998093 (g) -429.299987793 (th) 12.6000003815 (e) -426.5 (1) ] TJ
7.3499999046 0 0 6.5324001312 533.4235229492 665.2910766602 Tm
(st) Tj
9.7999000549 0 0 9.7999000549 304.7243041992 648.9636230469 Tm
[(an) 15.5 (d) -383 (t) 0 (h) 12.6000003815 (e) -386 (99) ] TJ
7.3499999046 0 0 6.5324001312 349.4549865723 653.3289794922 Tm
(th) Tj
9.7999000549 0 0 9.7999000549 359.4896850586 648.9636230469 Tm
[(or) -377.700012207 (b\)) -378.700012207 (th) 18.3999996185 (e) -386 (5) ] TJ
7.3499999046 0 0 6.5324001312 405.1841125488 653.3289794922 Tm
(th) Tj
9.7999000549 0 0 9.7999000549 415.2188110352 648.9636230469 Tm
[(an) 15.5 (d) -388.799987793 (9) 0 (5) ] TJ
7.3499999046 0 0 6.5324001312 443.508605957 653.3289794922 Tm
(th) Tj
9.7999000549 0 0 9.7999000549 453.5432128906 648.9636230469 Tm
[(pe) 17.7000007629 (rc) 12.1000003815 (en) 15.5 (ti) 20.7999992371 (le) 12.8000001907 (s) -384.3999938965 (o) 0 (f) -380.700012207 (e) 0 (n) 15.5 (e) 0 (r) 17.8999996185 (g) 0 (y) ] TJ
-15.1857004166 -1.2264000177 TD
[(in) 13.6999998093 (ta) 16.8999996185 (ke) -372 (as) -382.8999938965 (al) 12.8000001907 (l) 11.1999998093 (o) 0 (w) 13.6999998093 (a) 0 (b) 12.5 (l) 11.1999998093 (e) -386 (l) 11.1999998093 (im) 17 (its) -10.6999998093 (,) -377.8999938965 (c) 13.1000003815 (\)) -378 (a) 0 (f) 14.8999996185 (t) 0 (e) 16.8999996185 (r) -382.799987793 (ex) 27.7000007629 (cl) 12.8000001907 (ud) 13.3000001907 (i) 11.1999998093 (n) 0 (g) -374.799987793 (d) 0 (i) 15.8000001907 (a) 0 (b) 18.2000007629 (e) 0 (t) 11.1000003815 (i) 11.1999998093 (cs,) -384.700012207 (d\)) ] TJ
T*
[(af) 14.8999996185 (te) 16.8999996185 (r) -429.1000061035 (e) 0 (x) 27.7000007629 (c) 0 (l) 12.8000001907 (u) 0 (d) 19.1000003815 (i) 0 (n) 13.6999998093 (g) -429.299987793 (pa) 17.7000007629 (rt) 14.3999996185 (i) 11.1999998093 (c) 0 (i) 12.8000001907 (p) 0 (a) 17.7000007629 (nts) -424.5 (ol) 16.3999996185 (de) 11.8999996185 (r) -423.299987793 (t) 0 (h) 12.6000003815 (a) 0 (n) -418.299987793 (7) 0 (5) -423.1000061035 (y) 0 (e) 14.6999998093 (a) 0 (r) 17.8999996185 (s) -14.1999998093 (,) -429.8999938965 (e) 0 (\)) -422.700012207 (a) 0 (f) 14.8999996185 (t) 0 (e) 16.8999996185 (r) ] TJ
0 -1.220600009 TD
0.0208999999 Tc
[(ex) 12.3999996185 (cludin) 6 (g) -408.299987793 (p) -3.5 (articipant) -10 (s) -409.799987793 (y) -0.6999999881 (ounger) -408.200012207 (than) -410.6000061035 (65) -404.700012207 (years) -22.2000007629 (,) -409 (f) -104.5999984741 (\)) -409.200012207 (after) ] TJ
0 -1.2264000177 TD
0 Tc
[(de) 17.7000007629 (pu) 13.3000001907 (ra) 17.8999996185 (ti) 15.1000003815 (ng) -496.299987793 (th) 18.3999996185 (e) -507.5 (a) 0 (b) 18.2000007629 (s) 0 (t) 12.8000001907 (a) 0 (i) 18.6000003815 (n) 0 (e) 15.5 (r) 0 (s) ] TJ
/F8 1 Tf
10.7775001526 0 TD
<92> Tj
/F7 1 Tf
0.6132000089 0 TD
[(gr) 15.1999998093 (ou) 13.8999996185 (p) -504.5 (\() 0 (e) 16.8999996185 (x) 20.3999996185 (cl) 12.8000001907 (ud) 19.1000003815 (in) 13.6999998093 (g) -504.5 (p) 0 (a) 17.7000007629 (r) 0 (t) 14.3999996185 (i) 11.1999998093 (ci) 12.8000001907 (pa) 17.7000007629 (nts) ] TJ
-11.3907003403 -1.2264000177 TD
[(wh) 17.2999992371 (o) -330.3999938965 (r) 0 (e) 17.8999996185 (p) 0 (o) 15.5 (r) 0 (t) 14.3999996185 (e) 0 (d) -317.8999938965 (a) 0 (n) 15.5 (y) -328.200012207 (al) 18.6000003815 (co) 12.5 (ho) 13.8999996185 (l) -324.299987793 (i) 11.1999998093 (nt) 12 (ak) 15.6000003815 (e) -322.3999938965 (t) 0 (h) 12.6000003815 (r) 0 (o) 15.6999998093 (u) 0 (g) 19.2000007629 (h) 0 (o) 13.8999996185 (u) 0 (t) -317.200012207 (t) 0 (h) 12.6000003815 (e) 0 (i) 18.6000003815 (r) -330.799987793 (l) 11.1999998093 (i) 0 (f) 13 (e) -322.3999938965 (bu) 13.8999996185 (t) ] TJ
0 -1.220600009 TD
[(no) 13.3000001907 (t) -424.299987793 (c) 0 (u) 16.1000003815 (r) 0 (r) 21.1000003815 (e) 0 (n) 15.5 (t) 0 (l) 15.1000003815 (y) -426.5 (at) -405.3999938965 (bas) 9.8999996185 (el) 18.6000003815 (in) 13.6999998093 (e\)) 16.8999996185 (,) -424.1000061035 (g) 0 (\)) -413.8999938965 (a) 0 (f) 14.8999996185 (t) 0 (e) 16.8999996185 (r) -423.299987793 (in) 13.6999998093 (cl) 18.6000003815 (ud) 13.3000001907 (in) 13.6999998093 (g) -423.5 (p) 0 (a) 17.7000007629 (r) 0 (t) 14.3999996185 (i) 11.1999998093 (ci) 12.8000001907 (pa) 17.7000007629 (nts) ] TJ
0 -1.2264000177 TD
[(wi) 14 (th) -241.8999938965 (a) -253 (p) 0 (r) 15.1000003815 (i) 11.1999998093 (or) -244.6999969482 (hi) 14.1999998093 (st) 18.6000003815 (or) 15.6999998093 (y) -253 (o) 0 (f) -247.6999969482 (d) 0 (e) 17.7000007629 (p) 0 (r) 15.1000003815 (e) 0 (s) 16.2999992371 (s) 0 (i) 20.2000007629 (o) 0 (n) -247 (a) 0 (t) -231.8000030518 (bas) 9.8999996185 (el) 18.6000003815 (in) 13.6999998093 (e) -253 (a) 0 (n) 15.5 (d) -250 (in) 13.6999998093 (cl) 18.6000003815 (ud) 13.3000001907 (i) 11.1999998093 (n) 0 (g) ] TJ
T*
[(th) 12.6000003815 (i) 11.1999998093 (s) -372.799987793 (v) 12.6000003815 (a) 0 (r) 12.1000003815 (i) 11.1999998093 (ab) 12.5 (l) 11.1999998093 (e) -374.5 (i) 11.1999998093 (n) -367.799987793 (th) 12.6000003815 (e) -368.700012207 (m) 0 (u) 14.5 (l) 0 (t) 15.1000003815 (i) 11.1999998093 (pl) 15.8000001907 (e) -374.5 (a) 0 (d) 17.7000007629 (j) 0 (u) 15.8000001907 (s) 0 (t) 18.6000003815 (e) 0 (d) -364.1000061035 (m) 0 (o) 16.6000003815 (d) 0 (e) 11.8999996185 (l) 11.1999998093 (,) -372.1000061035 (a) 0 (n) 15.5 (d) -371.5 (h\)) -363.3999938965 (af) 14.8999996185 (te) 16.8999996185 (r) ] TJ
0 -1.220600009 TD
[(es) 16.2999992371 (ta) 16.8999996185 (bl) 10.6000003815 (i) 11.1999998093 (s) 0 (h) 17.7000007629 (i) 0 (n) 13.6999998093 (g) -290.3999938965 (a) -287.700012207 (t) 0 (w) 12.3999996185 (o) 10.8999996185 (-) -289.700012207 (t) 0 (o) -286.1000061035 (t) 0 (h) 18.3999996185 (r) 0 (e) 12.1000003815 (e) 0 (-) 18.3999996185 (y) 0 (e) 14.6999998093 (a) 0 (r) -282.8999938965 (i) 11.1999998093 (nd) 12.8000001907 (uc) 16.1000003815 (ti) 15.1000003815 (o) 10.8999996185 (n) -292.6000061035 (pe) 17.7000007629 (ri) 16 (od) -285.3999938965 (\(i) 20.7999992371 (ns) 11.3999996185 (te) 16.8999996185 (ad) ] TJ
0 -1.2264000177 TD
[(of) -421.200012207 (o) 10.8999996185 (n) 0 (e) -418.299987793 (t) 0 (o) -419.1000061035 (t) 0 (w) 12.3999996185 (o) -428.700012207 (ye) 14.6999998093 (ar) 17.8999996185 (s\)) -421.1000061035 (b) 10.8999996185 (e) 0 (t) 16.8999996185 (w) 0 (e) 10.1000003815 (e) 0 (n) -418.299987793 (e) 0 (x) 16.2000007629 (p) 0 (o) 15.5 (s) 0 (u) 17.7000007629 (r) 0 (e) -421.799987793 (a) 0 (n) 15.5 (d) -423.5 (ou) 13.8999996185 (tc) 16.8999996185 (om) 10.8999996185 (e) -426.5 (i) 11.1999998093 (n) ] TJ
T*
[(th) 12.6000003815 (e) -432.299987793 (r) 0 (e) 17.8999996185 (p) 0 (e) 17.7000007629 (a) 0 (t) 11.1999998093 (e) 0 (d) -422 (m) 0 (e) 13.1000003815 (asu) 13.5 (re) 17.8999996185 (me) 13.1000003815 (nt) -421.8999938965 (an) 15.5 (al) 12.8000001907 (ys) 16.2999992371 (es) 16.2999992371 (.) -429.8999938965 (M) 0 (o) 12.3000001907 (r) 0 (e) 17.8999996185 (o) 0 (v) 11.8999996185 (e) 0 (r) 93.0999984741 (,) -435.700012207 (to) -424.8999938965 (ass) 13.6999998093 (es) 16.2999992371 (s) ] TJ
0 -1.220600009 TD
[(th) 12.6000003815 (e) -281.8999938965 (i) 11.1999998093 (nf) 15.6999998093 (lu) 14.1999998093 (en) 15.5 (ce) -274.6000061035 (o) 10.8999996185 (f) -287.5 (wi) 19.7999992371 (ne) -285.299987793 (co) 12.5 (ns) 17.2000007629 (um) 14.5 (pt) 14.1999998093 (i) 11.1999998093 (o) 0 (n) -275.8999938965 (o) 10.8999996185 (n) -286.799987793 (t) 0 (h) 18.3999996185 (e) -281.8999938965 (dev) 12.8999996185 (el) 12.8000001907 (o) 10.8999996185 (p) 0 (m) 16.1000003815 (e) 0 (n) 15.5 (t) -285.3999938965 (o) 10.8999996185 (f) ] TJ
0 -1.2264000177 TD
[(de) 17.7000007629 (pr) 15.1000003815 (es) 16.2999992371 (si) 14.3999996185 (o) 10.8999996185 (n) 0 (,) -392.799987793 (w) 0 (e) -406.3999938965 (c) 0 (o) 18.2000007629 (n) 0 (d) 12.8000001907 (u) 0 (c) 16.1000003815 (t) 0 (e) 16.8999996185 (d) -400.3999938965 (bo) 16 (th) -392.3999938965 (Co) 11.1000003815 (x) -396.1000061035 (r) 0 (e) 12.1000003815 (g) 0 (r) 21 (e) 0 (s) 16.2999992371 (s) 0 (i) 14.3999996185 (o) 0 (n) -391.6000061035 (a) 0 (n) 15.5 (d) -400.3999938965 (GE) 16.7000007629 (E) ] TJ
T*
-0.0177999996 Tc
[(analy) -4.6999998093 (s) 2.7000000477 (es) -26.2000007629 (,) -256.799987793 (u) -3.2000000477 (sing) -261.8999938965 (absta) -4.6999998093 (i) -0.8000000119 (ners) -263.3999938965 (a) -17.7999992371 (s) -250.3000030518 (the) -259.200012207 (r) -1.5 (efe) -4.6999998093 (r) -1.5 (enc) -4.6999998093 (e) -270.799987793 (ca) -4.6999998093 (te) -4.6999998093 (gory) -4.6999998093 (.) -256.799987793 (I) -3 (n) -258.299987793 (t) -2.4000000954 (hese) ] TJ
0 -1.220600009 TD
-0.0172000006 Tc
[(analy) -4.0999999046 (s) 3.2999999523 (es) -25.6000003815 (,) -279.3999938965 (w) 2.9000000954 (e) -281.799987793 (a) 1.7000000477 (djusted) -284.5 (f) 1.8999999762 (or) -278.6000061035 (the) -281.799987793 (s) 3.2999999523 (a) -4.0999999046 (m) 0.1000000015 (e) -276 (p) -1.1000000238 (otential) -277.8999938965 (confounders) -280.1000061035 (a) -17.2000007629 (s) ] TJ
0 -1.2264000177 TD
[(me) -4.0999999046 (ntioned) -440.700012207 (a) 1.7000000477 (bove) -4.0999999046 (,) -435.6000061035 (and) -434.8999938965 (a) 1.7000000477 (lso) -434.3999938965 (f) -3.9000000954 (or) -434.700012207 (alc) -4.0999999046 (o) -0.5 (hol) -439.799987793 (i) -0.200000003 (ntake) -432.200012207 (f) -3.9000000954 (rom) -433.799987793 (o) -0.5 (ther) ] TJ
T*
0.0207000002 Tc
[(sources.) -391.8999938965 (A) -0.200000003 (dditionally,) -391.8999938965 (we) -394.299987793 (re-ran) -393.3999938965 (the) -394.299987793 (a) -0.8999999762 (nalyses) -392.6000061035 (f) -0.6999999881 (or) -391.1000061035 (wine) ] TJ
0 -1.220600009 TD
0.0209999997 Tc
[(consu) -4.9000000954 (m) 3.5999999046 (ption) -352.6000061035 (a) 5.1999998093 (mong) -350.3999938965 (only-wine) -347.700012207 (d) -3.4000000954 (rinkers) -351.799987793 (to) -349.8999938965 (control) -355.3999938965 (f) 5.4000000954 (or) ] TJ
0 -1.2264000177 TD
0 Tc
[(co) 12.5 (nf) 21.5 (ou) 13.8999996185 (nd) 12.8000001907 (i) 11.1999998093 (n) 0 (g) -253.3000030518 (b) 0 (y) -259.3999938965 (o) 10.8999996185 (th) 12.6000003815 (er) -254 (al) 18.6000003815 (co) 12.5 (ho) 19.7000007629 (li) 16.7000007629 (c) -264.6000061035 (bev) 13.3999996185 (er) 12.1000003815 (ag) 17.7000007629 (es) 16.2999992371 (.) ] TJ
0.8156999946 -1.2264000177 TD
-0.0136000002 Tc
[(Moreover) 72.1999969482 (,) -385.700012207 (w) 0.8000000119 (e) -388.1000061035 (e) -13.6000003815 (va) 5.3000001907 (luated) -390.8999938965 (the) -388.1000061035 (p) 2.5 (otential) -384.200012207 (non-linear) -384.8999938965 (a) -13.6000003815 (s) 2.7000000477 (soc) 5.3000001907 (i) -2.4000000954 (-) ] TJ
-0.8156999946 -1.220600009 TD
-0.0140000004 Tc
[(ation) -335.5 (b) 2.7000000477 (etw) -14 (e) 7.6999998093 (en) -329.799987793 (alcohol) -332.5 (i) 3 (ntake) -336.3999938965 (a) -0.8999999762 (nd) -333.3999938965 (incid) -14 (e) 9.5 (nt) -334.1000061035 (depress) -14 (i) 12 (on) -329.799987793 (with) ] TJ
0 -1.2264000177 TD
-0.0142999999 Tc
[(the) -296.200012207 (u) 0.3000000119 (se) -296.200012207 (of) -296 (restr) -14.3000001907 (i) 13.3000001907 (cted) -293.200012207 (cubic) -296.200012207 (s) 0.5 (plines) -22.7000007629 (,) -293.799987793 (f) 4.8000001907 (or) -293 (part) -14.3000001907 (i) 12.3000001907 (c) -1.2000000477 (ipant) -14.3000001907 (s) -290.799987793 (drinking) ] TJ
T*
0.0097000003 Tc
[(no) -419 (more) -422.6000061035 (th) -4.6999998093 (an) -416 (80) -421.700012207 (grams) -421 (o) 9.6999998093 (f) -428.8999938965 (a) -0.3000000119 (lco) 9.6999998093 (h) -11.1000003815 (ol) -418.700012207 (per) -419.3999938965 (d) -3.0999999046 (ay) -416.799987793 (\(99.4) -5.1999998093 (2) 0.6000000238 (%) -421.3999938965 (o) 9.6999998093 (f) ] TJ
0 -1.220600009 TD
0 Tc
[(p) -12.8000001907 (a) -10 (r) -6.8000001907 (t) -13.5 (ic) -21.8999996185 (ip) -18.8999996185 (a) -10 (n) -9.1000003815 (t) -25.1000003815 (s) -8.3999996185 (\)) -279.6000061035 ([) -13.5 (2) -9.1000003815 (8) -9.1000003815 (]) -7.6999998093 (.) ] TJ
0.8156999946 -1.2264000177 TD
[(Fi) 16.3999996185 (na) 15.5 (ll) 16.7000007629 (y,) -405.200012207 (we) -406.3999938965 (ex) 16.2000007629 (am) 13.1000003815 (in) 13.6999998093 (ed) -404.6000061035 (th) 18.3999996185 (e) -415 (i) 11.1999998093 (nc) 15.5 (id) 15.8000001907 (en) 15.5 (ce) -407.6000061035 (an) 15.5 (d) -412 (rec) 13.6000003815 (ov) 11.8999996185 (er) 17.8999996185 (y) -415 (f) 0 (r) 18.1000003815 (o) 10.8999996185 (m) ] TJ
-0.8156999946 -1.2264000177 TD
[(de) 17.7000007629 (pr) 15.1000003815 (es) 16.2999992371 (si) 14.3999996185 (o) 10.8999996185 (n) -437.200012207 (a) 13.1000003815 (p) 0 (p) 14.8999996185 (l) 0 (y) 12.8000001907 (i) 11.1999998093 (ng) -432.6000061035 (fi) 13 (xe) 16.2000007629 (d-) 15.6999998093 (ef) 14.8999996185 (fec) 10.6000003815 (ts) -432.700012207 (re) 17.8999996185 (gr) 15.1999998093 (es) 16.2999992371 (si) 14.3999996185 (o) 10.8999996185 (n) -431.5 (as) -434.8999938965 (su) 12 (gg) 20.7999992371 (es) 16.2999992371 (te) 11.1999998093 (d) ] TJ
0 -1.220600009 TD
-0.0115 Tc
[(b) -11.5 (y) -334.6000061035 (Fe) -11.5 (rg) -11.5 (u) 7.6999998093 (s) -11.5 (son) ] TJ
/F9 1 Tf
5.7618999481 0 TD
-0.0109999999 Tc
[(et) -354.299987793 (a) -11 (l) ] TJ
/F7 1 Tf
1.8628000021 0 TD
0 Tc
[(.) -331.6000061035 ([) 9.6000003815 (29) 16.5 (]) -331.700012207 (t) 0 (o) -320.799987793 (c) 0 (o) 18.2000007629 (n) 0 (t) 12 (r) 0 (o) 15.6999998093 (l) -330.1000061035 (fo) 18.3999996185 (r) -330.799987793 (o) 10.8999996185 (bs) 14.1000003815 (er) -16.7999992371 (ve) 14.1000003815 (d) -325.200012207 (a) 0 (n) 15.5 (d) -331 (no) 13.3000001907 (n-) ] TJ
-7.6247000694 -1.2264000177 TD
[(ob) 16 (se) 16.2999992371 (r) -24.2000007629 (v) 0 (e) 14.1000003815 (d) -261.6000061035 (fa) 14.8999996185 (ct) 16.8999996185 (or) 15.6999998093 (s) -262.8999938965 (t) 0 (h) 18.3999996185 (a) 0 (t) -255 (d) 0 (o) -256.3999938965 (n) 0 (o) 13.3000001907 (t) -262.299987793 (v) 12.6000003815 (a) 0 (r) 12.1000003815 (y) -258.799987793 (fo) 12.6999998093 (r) -261.3999938965 (a) -270.299987793 (su) 12 (b) 10.8999996185 (jec) 10.1000003815 (t) -262.299987793 (o) 10.8999996185 (ve) 14.1000003815 (r) -261.299987793 (t) 0 (i) 15.1000003815 (m) 0 (e) 13.1000003815 (.) ] TJ
/F5 1 Tf
10.3000001907 0 0 10.3000001907 304.7243041992 288.9637145996 Tm
(Results) Tj
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 276.9448852539 Tm
-0.0188999996 Tc
[(T) 10.6999998093 (h) -4.3000001907 (e) -474.3999938965 (m) -1.6000000238 (a) -5.8000001907 (i) 3.9000000954 (n) -479.299987793 (c) 0 (hara) -5.8000001907 (cte) -5.8000001907 (r) 3.2000000477 (istics) -478.5 (of) -474.200012207 (the) -480.200012207 (5) 0.8999999762 (,505) -479.200012207 (partic) -5.8000001907 (ipant) -18.8999996185 (s) -474.700012207 (\(2,683) ] TJ
T*
-0.0177999996 Tc
[(males) -431.1000061035 (a) -4.6999998093 (nd) -429.799987793 (2,822) -431.799987793 (f) 1.2999999523 (emales\)) -436.299987793 (acc) -4.6999998093 (ording) -429.700012207 (to) -429.200012207 (the) -4.6999998093 (i) 5 (r) -435.299987793 (t) 3.4000000954 (otal) -428.8999938965 (a) -4.6999998093 (l) 5 (c) -4.6999998093 (o) 4.6999998093 (hol) ] TJ
0 -1.220600009 TD
-0.0187999997 Tc
[(intake) -503.200012207 (are) -503.200012207 (s) 1.7000000477 (hown) -502.299987793 (in) -502.299987793 (T) 91.8000030518 (a) 0.1000000015 (ble) -503.200012207 (1) 1 (.) -500.799987793 (A) -18.7999992371 (s) -493.6000061035 (m) -1.5 (entioned) -500.200012207 (before) -5.6999998093 (,) -495 (t) -3.4000000954 (his) ] TJ
0 -1.2264000177 TD
-0.0184000004 Tc
[(Medite) -5.3000001907 (rranea) -5.3000001907 (n) -334.200012207 (p) -2.2999999523 (opula) -5.3000001907 (t) 2.7999999523 (ion) -334.200012207 (c) -5.3000001907 (onsisted) -337.799987793 (of) -334.799987793 (olde) -5.3000001907 (r) -331.799987793 (m) -1.1000000238 (e) -5.3000001907 (n) -334.200012207 (and) -337.799987793 (w) 1.7999999523 (o-) ] TJ
T*
-0.0192000009 Tc
[(men,) -420.200012207 (with) -421.200012207 (a) -422.6000061035 (m) -1.8999999762 (ean) -415.8999938965 (age) -422.6000061035 (o) 3.2999999523 (f) -422.3999938965 (6) 0.6000000238 (7) -421.700012207 (years.) -420.200012207 (Higher) -419.3999938965 (alcohol) -418.700012207 (i) -2.2000000477 (ntake) ] TJ
0 -1.220600009 TD
-0.0208999999 Tc
[(wa) -20.8999996185 (s) -403.799987793 (p) 1 (o) -4.1999998093 (s) -0.400000006 (i) -3.9000000954 (t) 0.3000000119 (i) -3.9000000954 (v) -2.5999999046 (ely) -412.700012207 (a) -20.8999996185 (s) 7 (s) -0.400000006 (o) -4.1999998093 (c) -2 (iat) -5.5 (e) -2 (d) -409.700012207 (w) -0.8000000119 (it) -5.5 (h) -411.299987793 (b) 1.6000000238 (ei) -3.9000000954 (ng) -409.700012207 (m) -3.5999999046 (a) -2 (le) -412.700012207 (\(88%) -411.5 (o) -4.1999998093 (f) -406.799987793 (p) -4.8000001907 (a) -2 (rt) -5.5 (ici) -3.9000000954 (-) ] TJ
0 -1.2264000177 TD
-0.0189999994 Tc
[(pant) -19 (s) -376.3999938965 (d) 2.9000000954 (rinking) -384.6000061035 (more) -387.700012207 (than) -386.799987793 (15) -386.799987793 (g/day) -387.700012207 (w) 1.1000000238 (ere) -387.700012207 (m) 4.0999999046 (ale\),) -385.299987793 (p) -2.9000000954 (racticing) ] TJ
T*
-0.0186999999 Tc
[(more) -375.799987793 (leisure-time) -375.799987793 (physical) -377.700012207 (activity,) -379.200012207 (being) -378.5 (a) -375.799987793 (c) -5.5999999046 (u) 1.6000000238 (rrent) -379.299987793 (o) 3.7999999523 (r) -378.3999938965 (f) 0.400000006 (or) 20.7999992371 (-) ] TJ
0 -1.220600009 TD
-0.0193000007 Tc
[(mer) -367.3999938965 (s) 1.2000000477 (moker) 72.1999969482 (,) -368.200012207 (ha) 11.1999998093 (ving) -361.799987793 (h) -4.6999998093 (i) 3.5 (gher) -367.3999938965 (total) -366.700012207 (e) -0.400000006 (nergy) -364.8999938965 (i) -2.2999999523 (ntake,) -368.200012207 (being) -367.6000061035 (m) -2 (ar) 20.2000007629 (-) ] TJ
0 -1.2264000177 TD
-0.0195000004 Tc
[(ried,) -270.1000061035 (b) -2.7999999523 (ut) -270.200012207 (it) -270.200012207 (wa) -19.5 (s) -263.5 (i) -2.5 (nversely) -272.5 (a) -6.4000000954 (s) -4.6999998093 (soci) ] TJ
12.2353000641 0 TD
-0.0193000007 Tc
[(ated) -275.1000061035 (with) -270.799987793 (educational) -274.200012207 (l) 3.5 (e) -19.2999992371 (v) 6.4000000954 (el.) ] TJ
-11.4195995331 -1.2264000177 TD
0 Tc
[(A) -298.6000061035 (total) -304.200012207 (of) -293.8999938965 (443) -299.200012207 (inciden) -11.3000001907 (t) -297 (c) 0 (a) -14.3000001907 (ses) -298.700012207 (of) -294 (depr) -7.6999998093 (ession) -303 (were) -301.799987793 (identi-) ] TJ
-0.8156999946 -1.220600009 TD
[(fied) -420.6000061035 (durin) -8.8000001907 (g) -417.700012207 (the) -419.700012207 (follow-u) -12.3000001907 (p) -417.799987793 (period) -8.6999998093 (,) -418.3999938965 (which) -423.8999938965 (accrued) -427 (23,655) ] TJ
0 -1.2264000177 TD
[(person-y) -12 (ears.) ] TJ
0.8156999946 -1.2264000177 TD
-0.0136000002 Tc
[(T) 10.3000001907 (h) 1 (e) -278.200012207 (C) 3.9000000954 (ox) -270.8999938965 (r) -13.6000003815 (e) 10.1000003815 (gression) -277.299987793 (analysis) -270.700012207 (using) -275.1000061035 (b) 3.0999999046 (a) -13.6000003815 (s) 2.7000000477 (eline) -272.3999938965 (a) -0.5 (lc) 5.3000001907 (ohol) -274.200012207 (intake) ] TJ
-0.8156999946 -1.220600009 TD
-0.0141000003 Tc
[(a) -14.1000003815 (s) -431.700012207 (exposure) -434.8999938965 (showed) -431.799987793 (an) -434 (inverse) -434.8999938965 (a) -14.1000003815 (ssociation) -434 (be) 4.8000001907 (t) -14.1000003815 (w) 9.8999996185 (een) -434 (tot) -14.1000003815 (a) 8.6000003815 (l) ] TJ
0 -1.2264000177 TD
-0.0143999998 Tc
[(alcohol) -263.5 (i) -3.2000000477 (ntake) -267.3999938965 (a) -1.2999999523 (nd) -270.200012207 (the) -267.3999938965 (i) -3.2000000477 (ncidence) -273.200012207 (of) -267.200012207 (d) -14.3999996185 (e) 9.1000003815 (pression,) -270.799987793 (w) 0 (it) -14.3999996185 (h) -256.299987793 (n) -0.400000006 (o) -269.6000061035 (s) 0.400000006 (ig-) ] TJ
T*
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[(Total) -293.3999938965 (energy) -296.3999938965 (intake) -295.799987793 (\(Kcal/day) 8.8999996185 (\)) -11383.400390625 (2,054) -299.1000061035 (\(511\)) -6561.2001953125 (2,184) -292 (\(509\)) -6568.2998046875 (2,330) -292 (\(511\)) -6561.2001953125 (2,595) -299.1000061035 (\(533\)) ] TJ
0 -1.7503999472 TD
[(Alcohol) -294.700012207 (\(g/day\)) -17063.30078125 (-) -10608.2998046875 (2.0) -300.3999938965 (\(1.4\)) -7830.8999023438 (9.8) -293.299987793 (\(2.7\)) -7830.8999023438 (35) -296.299987793 (\(17\)) ] TJ
T*
[(Wine) -294.3999938965 (\(g) -297.3999938965 (alcohol/day\)) -14872.099609375 (-) -10608.2998046875 (1.3) -300.3999938965 (\(1.4\)) -7830.8999023438 (7.4) -293.299987793 (\(3.7\)) -7830.8999023438 (25) -296.299987793 (\(16\)) ] TJ
T*
[(Beer) -292 (\(g) -304.5 (alcohol/) 11.5 (day\)) -15160 (-) -10608.2998046875 (0.5) -300.3999938965 (\(0.9\)) -7830.8999023438 (1.7) -293.299987793 (\(2.7\)) -7830.8999023438 (4.8) -300.3999938965 (\(8.4\)) ] TJ
T*
[(Spirits) -292.6000061035 (\(g) -304.5 (alcohol/) 11.5 (day\)) -14536.400390625 (-) -10608.2998046875 (0.2) -300.3999938965 (\(0.5\)) -7830.8999023438 (0.6) -293.299987793 (\(1.5\)) -7830.8999023438 (4.2) -300.3999938965 (\(8.8\)) ] TJ
/F1 1 Tf
6.9998998642 0 0 6.9998998642 56.6929016113 448.6109008789 Tm
[(Mean) -307.3999938965 (and) -302.200012207 (Standard) -307 (Dev) -9.1999998093 (iations,) -303.799987793 (or) -303.299987793 (%.) -307.8999938965 (The) -297.5 (PREDI) -10 (MED) -304.6000061035 (Study) -307 (2003) -300.700012207 (to) -303.299987793 (2010.) -306.200012207 (BM) -9.6000003815 (I,) -294.799987793 (bod) -11.6000003815 (y) -301.3999938965 (mass) -303.5 (index;) -304.3999938965 (MET) -10 (,) -297 (metabo) -10.8000001907 (lic) -301.799987793 (equival) -10.1999998093 (ent) -302.6000061035 (task.) ] TJ
ET
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q
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Q
538.5830078125 119.9619979858 -481.8900146484 0.1133700013 re
B*
190.6580047607 246.1040039062 -133.9649963379 0.1700700074 re
B*
244.6300048828 246.1040039062 -53.9720001221 0.1700700074 re
B*
324.1700134277 246.1040039062 -79.5400009155 0.1700700074 re
B*
403.7099914551 246.1040039062 -79.5400009155 0.1700700074 re
B*
483.3070068359 246.1040039062 -79.5970001221 0.1700700074 re
B*
538.5830078125 246.1040039062 -55.2760009766 0.1700700074 re
B*
BT
/F5 1 Tf
9 0 0 9 56.6929016113 263.3952026367 Tm
[(Table) -302.3999938965 (2) -298.3999938965 (Risks) -303.200012207 (of) -298.1000061035 (depression) -297.8999938965 (according) -302.8999938965 (to) -304.8999938965 (categories) -302.700012207 (of) -298.1000061035 (daily) -302.6000061035 (alcohol) -299.799987793 (intake) ] TJ
/F10 1 Tf
7.9998998642 0 0 7.9998998642 56.6929016113 250.2424926758 Tm
0 0 0 rg
[(Alcohol) -294.799987793 (intake) -294.299987793 (categories) -295.8999938965 (\(g/day\)) ] TJ
/F6 1 Tf
16.7458000183 0 TD
[(0) -6215.5 (>) 0 (0) -300.3999938965 (t) 0 (o) -299.700012207 (5) -6782.3999023438 (>5) -300.3999938965 (to) -299.700012207 (15) -6251.3999023438 (>15) ] TJ
/F10 1 Tf
36.581401825 0 TD
(P) Tj
/F6 1 Tf
0.8291000128 0 TD
[(for) -295.6000061035 (liner) -292.1000061035 (trend) ] TJ
/F2 1 Tf
-37.4104995728 -1.6440999508 TD
[(Baseline) -291.8999938965 (alcohol) -296 (intake) ] TJ
5.9998002052 0 0 5.3324999809 263.225189209 240.6614074707 Tm
(a) Tj
7.9998998642 0 0 7.9998998642 56.6929016113 223.0865936279 Tm
[(Cases/Perso) 11.3000001907 (n-years) -9193.2001953125 (195/7,777) -2884.5 (114/5,728) -6080.6000976562 (79/5,390) -6559.6000976562 (55/4,760) ] TJ
0 -1.7503999472 TD
[(Crude) -292.8999938965 (model) -11489 (1) -300.5 (\(Ref.\)) -4042 (0.79) -296.200012207 (\(0.63) -298.3999938965 (to) -293.799987793 (1.00\)) -2892.1999511719 (0.59) -296.200012207 (\(0.46) -298.3999938965 (to) -293.799987793 (0.77\)) -2892.1999511719 (0.44) -296.200012207 (\(0.33) -298.3999938965 (to) -300.8999938965 (0.60\)) -2892.1999511719 (<0.001) ] TJ
T*
[(Age) -296.200012207 (and) -295.200012207 (sex-adjusted) -8069.3999023438 (1) -300.5 (\(Ref.\)) -4042 (0.91) -296.200012207 (\(0.72) -298.3999938965 (to) -293.799987793 (1.15\)) -2892.1999511719 (0.81) -296.200012207 (\(0.62) -298.3999938965 (to) -293.799987793 (1.07\)) -2892.1999511719 (0.81) -296.200012207 (\(0.58) -298.3999938965 (to) -300.8999938965 (1.14\)) -2892.1999511719 (0.347) ] TJ
T*
[(Multiple-adj) 10.3000001907 (usted) -295.6000061035 (model) ] TJ
5.9998002052 0 0 5.3324999809 134.9290924072 184.6488037109 Tm
(c) Tj
7.9998998642 0 0 7.9998998642 190.658203125 181.0771026611 Tm
[(1) -300.5 (\(Ref.\)) -4042 (0.97) -296.200012207 (\(0.75) -298.3999938965 (to) -293.799987793 (1.25\)) -2892.1999511719 (0.72) -296.200012207 (\(0.53) -298.3999938965 (to) -293.799987793 (0.98\)) -2892.1999511719 (0.79) -296.200012207 (\(0.53) -298.3999938965 (to) -300.8999938965 (1.16\)) -2892.1999511719 (0.522) ] TJ
T*
[(Updated) -294.1000061035 (alcohol) -288.8999938965 (intake) ] TJ
5.9998002052 0 0 5.3324999809 265.3228149414 170.6455993652 Tm
(b) Tj
7.9998998642 0 0 7.9998998642 56.6929016113 153.1275024414 Tm
[(Crude) -292.8999938965 (model) -11489 (1) -300.5 (\(Ref.\)) -4042 (0.63) -296.200012207 (\(0.49) -298.3999938965 (to) -293.799987793 (0.81\)) -2892.1999511719 (0.49) -296.200012207 (\(0.37) -298.3999938965 (to) -293.799987793 (0.66\)) -2892.1999511719 (0.37) -296.200012207 (\(0.26) -298.3999938965 (to) -300.8999938965 (0.52\)) -2892.1999511719 (<0.001) ] TJ
T*
[(Age) -296.200012207 (and) -295.200012207 (sex-adjusted) -8069.3999023438 (1) -300.5 (\(Ref.\)) -4042 (0.73) -296.200012207 (\(0.56) -298.3999938965 (to) -293.799987793 (0.94\)) -2892.1999511719 (0.71) -296.200012207 (\(0.52) -298.3999938965 (to) -293.799987793 (0.97\)) -2892.1999511719 (0.71) -296.200012207 (\(0.48) -298.3999938965 (to) -300.8999938965 (1.05\)) -2892.1999511719 (0.727) ] TJ
T*
[(Multiple-adj) 10.3000001907 (usted) -295.6000061035 (model) ] TJ
5.9998002052 0 0 5.3324999809 134.9290924072 128.6361999512 Tm
(c) Tj
7.9998998642 0 0 7.9998998642 190.658203125 125.1212005615 Tm
[(1) -300.5 (\(Ref.\)) -4042 (0.73) -296.200012207 (\(0.57) -298.3999938965 (to) -293.799987793 (0.95\)) -2892.1999511719 (0.69) -296.200012207 (\(0.50) -298.3999938965 (to) -293.799987793 (0.96\)) -2892.1999511719 (0.69) -296.200012207 (\(0.46) -298.3999938965 (to) -300.8999938965 (1.04\)) -2892.1999511719 (0.773) ] TJ
/F1 1 Tf
5.2498002052 0 0 4.6661000252 56.6929016113 115.0866012573 Tm
(a) Tj
6.9998998642 0 0 6.9998998642 59.1874008179 111.96849823 Tm
[(Hazard) -309.5 (ratios) -303.799987793 (\(95%) -305.3999938965 (confi) -13.3999996185 (dence) -306.200012207 (intervals\)) -310.299987793 (for) -303.8999938965 (incident) -308.3999938965 (depression) -309.700012207 (accord) -12.5 (ing) -303 (to) -303.299987793 (categories) -305.299987793 (of) -301.8999938965 (baseli) -11.5 (ne) -300.6000061035 (daily) -308.8999938965 (alcohol) -302.700012207 (intake.) ] TJ
5.2498002052 0 0 4.6661000252 56.6929016113 106.5827026367 Tm
(b) Tj
6.9998998642 0 0 6.9998998642 59.6408996582 103.4645996094 Tm
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62.1688995361 0 TD
(reverse) Tj
-62.5900993347 -1.2149000168 TD
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65.3016967773 0 TD
[(ccurrin) -16.8999996185 (g) ] TJ
-65.3016967773 -1.2149000168 TD
[(only) -307.700012207 (during) -303.5 (the) -302.5 (secon) -11 (d) -296.5 (year) -304.3999938965 (of) -301.8999938965 (ev) -9.1000003815 (ery) -297.5 (tw) -10 (o-year) -303.799987793 (follow-up) -311.3999938965 (interval.) ] TJ
5.2498002052 0 0 4.6661000252 56.6929016113 81.0708999634 Tm
(c) Tj
6.9998998642 0 0 6.9998998642 59.0172996521 77.9526977539 Tm
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5.2498002052 0 0 4.6661000252 427.4078063965 81.0708999634 Tm
(2) Tj
6.9998998642 0 0 6.9998998642 430.0722961426 77.9526977539 Tm
[(\),) -299.5 (marital) -306.200012207 (status,) -313.3999938965 (intervention) -310.299987793 (group,) ] TJ
-53.3409004211 -1.2149000168 TD
[(recruiting) -309 (cente) -11.6000003815 (r,) -299 (educati) -14 (onal) -296.700012207 (leve) -9.1000003815 (l) -297.3999938965 (and) -302.200012207 (the) -302.5 (num) -9.6999998093 (ber) -300.700012207 (of) -301.8999938965 (pers) -10.8999996185 (ons) -301.8999938965 (living) -305.6000061035 (at) -300.5 (home.) ] TJ
T*
[(The) -305.6000061035 (PREDIMED) -306.5 (Study) -307 (2003) -308.799987793 (to) -303.299987793 (2010.) ] TJ
7.9998998642 0 0 7.9998998642 56.6929016113 753.2786254883 Tm
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(Gea) Tj
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[(et) -296.8999938965 (al.) -301.299987793 (BMC) -294 (Medicine) ] TJ
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[(Page) -297.8999938965 (4) -297.8999938965 (o) 0 (f) -294.799987793 (1) 0 (0) ] TJ
-54.9216995239 -1.2473000288 TD
[(http://ww) 11.1999998093 (w.biomedce) 11.6999998093 (ntral.com/1) 9.8000001907 (741-7015/11/192) ] TJ
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