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|Comparative study of PrPc expression in rat, monkey and cow gastrointestinal tract|
|Authors: ||Marcos, Z. (Z.)|
Sesma, M.P. (María Pilar)
Guembe, L. (L.)
|Keywords: ||Prion diseases|
|Issue Date: ||12-Jan-2006|
|Publisher version: ||http://dx.doi.org/10.1196/annals.1327.071/pdf|
|Citation: ||Marcos Z, Bodegas ME, Sesma MP, Guembe L. Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract. Ann N Y Acad Sci 2005 Apr;1040:391-394.|
ABSTRACT: The gastrointestinal tract (GIT) appears to be the main site of entry
for the pathological isoform of prions (PrPsc). To understand how the PrPsc
internalization process occurs, it is important to characterize the cell types that
express normal prion protein (PrPc) along the GIT. To do so, we studied the distribution
of PrPc in the rat, monkey, and cow GIT. Using Western blot analysis,
we found that PrPc is expressed in all digestive regions of the three species.
Immunoreactivity for PrPc was found throughout the GIT in epithelial cells
sharing the neuroendocrine (NE) phenotype. Immunostained cells appeared
scattered throughout the epithelium of fundic and pyloric glands as well as in
intestinal villi and crypts.
|Permanent link: ||http://hdl.handle.net/10171/12552|
|Appears in Collections:||DA - Ciencias - HAP - Artículos de revista|
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