PRDM16: The intercovertible adipo-myocyte switch
Keywords: 
Interconvertible
Adipo-myocyte
Switch
Issue Date: 
Apr-2009
Publisher: 
Elsevier
ISSN: 
0962-8924
Citation: 
Fruhbeck G, Sesma P, Burrell MA. PRDM16: the interconvertible adipo-myocyte switch. Trends Cell Biol 2009 Apr;19(4):141-146.
Abstract
Both brown and white adipocytes were previously considered to be derived from the same precursor cell, despite being histologically and functionally different. However, a recent study shows that overexpression of the transcriptional regulator positive regulatory domain containing 16 (PRDM16) determines the development of brown adipocytes from a progenitor that expresses myoblast markers. Surprisingly, loss of PRDM16 from these precursors does not lead to white adipocyte differentiation. Thus, PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes

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