Both brown and white adipocytes were previously
considered to be derived from the same precursor cell,
despite being histologically and functionally different.
However, a recent study shows that overexpression of
the transcriptional regulator positive regulatory domain
containing 16 (PRDM16) determines the development of
brown adipocytes from a progenitor that expresses
myoblast markers. Surprisingly, loss of PRDM16 from
these precursors does not lead to white adipocyte differentiation.
Thus, PRDM16 controls a bidirectional cell fate
switch between skeletal myoblasts and brown adipocytes