Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Puerta, E. (Elena) | - |
dc.creator | Hervias, I. (Isabel) | - |
dc.creator | Barros-Miñones, L. (Lucía) | - |
dc.creator | Jordan, J. (Joaquín) | - |
dc.creator | Ricobaraza, A. (Ana) | - |
dc.creator | Cuadrado-Tejedor, M. (Mar) | - |
dc.creator | Garcia-Osta, A. (Ana) | - |
dc.creator | Aguirre, N. (Norberto) | - |
dc.date.accessioned | 2010-09-23T13:50:09Z | - |
dc.date.available | 2010-09-23T13:50:09Z | - |
dc.date.issued | 2010-05-02 | - |
dc.identifier.citation | Puerta E, Hervias I, Barros-Minones L, Jordan J, Ricobaraza A, Cuadrado-Tejedor M, et al. Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.Neurobiol Dis 2010 May;38(2):237-245. | es_ES |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | https://hdl.handle.net/10171/12941 | - |
dc.description.abstract | In this study we tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington's Disease (HD). The neurotoxin was given over 5 days by constant systemic infusion using osmotic minipumps. Animals treated with PDE5 inhibitors (sildenafil or vardenafil) showed improved neurologic scores, reduced the loss of striatal DARPP-32 protein levels and lesion volumes, and decreased calpain activation produced by 3NP. This protective effect was independent of changes in 3NP-induced succinate dehydrogenase inhibition. Furthermore, striatal p-CREB levels along with the expression of BDNF were significantly increased in sildenafil-treated rats. In summary, PDE5 inhibitors protected against 3NP-induced striatal degeneration by reducing calpain activation and by promoting survival pathways. These data encourage further evaluation of PDE5 inhibitors in transgenic mouse models of HD. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | 3-Nitropropionic acid | es_ES |
dc.subject | BDNF | es_ES |
dc.subject | Calpain | es_ES |
dc.subject | CREB | es_ES |
dc.subject | Excitotoxicity | es_ES |
dc.subject | Huntington's disease | es_ES |
dc.subject | Phosphodiesterase 5 | es_ES |
dc.subject | Sildenafil | es_ES |
dc.subject | Vardenafil | es_ES |
dc.title | Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB and BDNF | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.nbd.2010.01.013 | es_ES |
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