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dc.creatorSimon, A.M. (Ana María)-
dc.creatorLopez-de-Maturana, R. (Raquel)-
dc.creatorRicobaraza, A. (Ana)-
dc.creatorEscribano, L. (L.)-
dc.creatorSchiapparelli, L. (Lucio)-
dc.creatorCuadrado-Tejedor, M. (Mar)-
dc.creatorPerez-Mediavilla, L.A. (Luis Alberto)-
dc.creatorAvila, J. (Jesús)-
dc.creatorRio, J. (Joaquín) del-
dc.creatorFrechilla, D. (Diana)-
dc.date.accessioned2010-10-04T11:40:12Z-
dc.date.available2010-10-04T11:40:12Z-
dc.date.issued2009-01-22-
dc.identifier.citationSimon AM, de Maturana RL, Ricobaraza A, Escribano L, Schiapparelli L, Cuadrado-Tejedor M, et al. Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease. J Alzheimers Dis 2009;17(4):773-786.es_ES
dc.identifier.isbn1387-2877-
dc.identifier.urihttp://hdl.handle.net/10171/13229-
dc.description.abstractAbstract. Synapse loss occurs early in Alzheimer’s disease (AD) and is considered the best pathological correlate of cognitive decline. Ephrins and Eph receptors are involved in regulation of excitatory neurotransmission and play a role in cytoskeleton remodeling. We asked whether alterations in Eph receptors could underlie cognitive impairment in an AD mouse model overexpressing human amyloid-β protein precursor (hAβPP) with familial mutations (hAβPPswe-ind mice). We found that EphA4 and EphB2 receptors were reduced in the hippocampus before the development of impaired object recognition and spatial memory. Similar results were obtained in another line of transgenic AβPP mice, Tg2576. A reduction in Eph receptor levels was also found in postmortem hippocampal tissue from patients with incipient AD. At the time of onset of memory decline in hAβPPswe-ind mice, no change in surface expression of AMPA or NMDA receptor subunits was apparent, but we found changes in Eph-receptor downstream signaling, in particular a decrease in membrane-associated phospho-cofilin levels that may cause cytoskeletal changes and disrupted synaptic activity. Consistent with this finding, Eph receptor activation in cell culture increased phospho-cofilin levels. The results suggest that alterations in Eph receptors may play a role in synaptic dysfunction in the hippocampus leading to cognitive impairment in a model of AD.es_ES
dc.language.isoenges_ES
dc.publisherIOS Presses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAlzheimer's diseasees_ES
dc.subjectCofilines_ES
dc.subjectEphrines_ES
dc.subjectEph receptores_ES
dc.subjectGlutamate receptores_ES
dc.subjectLIM-kinasees_ES
dc.subjectMemoryes_ES
dc.subjectP21-activated kinasees_ES
dc.titleEarly Changes in Hippocampal Eph Receptors Precede the Onset of Memory Decline in Mouse Models of Alzheimer’s Diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3233/JAD-2009-1096es_ES

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