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Dadun > Depósito Académico > Facultad de Ciencias > Departamento de Histología y Anatomía Patológica > DA - Ciencias - HAP - Artículos de revista >

Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat
Autor(es) : Mazo, M. (Manuel)
Gavira, J.J. (Juan José)
Abizanda, G. (Gloria)
Moreno, C. (Cristina)
Ecay, M. (M.)
Soriano, M. (Mario)
Aranda, P. (P.)
Collantes, M. (María)
Alegria, E. (Eduardo)
Merino, J. (Juana)
Peñuelas, I. (Iván)
Garcia-Verdugo, J.M. (José Manuel)
Pelacho, B. (Beatriz)
Prosper, F. (Felipe)
Palabras clave : Bone marrow stem cells
Angiogenesis
Chronic myocardial infarction
Cardiac remodeling
Fecha incorporación: nov-2009
Editorial : Cognizant Communication Corporation
Versión del editor: http://dx.doi.org/10.3727/096368909X480323
ISSN: 0963-6897
Cita: Mazo M, Gavira JJ, Abizanda G, Moreno C, Ecay M, Soriano M, et al. Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat. Cell Transplant 2010;19(3):313-328.
Resumen
The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to receive intramyocardial injection of 106 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and 18F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1 and 2 weeks and 1 and 3 months). The main findings of this study were that both BM-derived populations, BM-MNC and MSC, induced a long-lasting (3 months) improvement in LVEF (BM-MNC: 26.61 ± 2.01% to 46.61 ± 3.7%, p < 0.05; MSC: 27.5 ± 1.28% to 38.8 ± 3.2%, p < 0.05) but remarkably, only MSC improved tissue metabolism quantified by 18FFDG uptake (71.15 ± 1.27 to 76.31 ± 1.11, p < 0.01), which was thereby associated with a smaller infarct size and scar collagen content and also with a higher revascularization degree. Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI.
Enlace permanente: http://hdl.handle.net/10171/13519
Aparece en las colecciones: DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CIMA - Servicios de apoyo - Micropet - Artículos de revista
DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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