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dc.creatorCollantes, M. (María)
dc.creatorPrieto-Azcárate, E. (Elena)
dc.creatorPeñuelas-Sanchez, I. (Ivan)
dc.creatorBlesa, J. (Javier)
dc.creatorJuri, C. (Carlos)
dc.creatorMarti-Climent, J.M. (Josep María)
dc.creatorQuincoces, G. (Gemma)
dc.creatorArbizu, J. (Javier)
dc.creatorRiverol, M. (Mario)
dc.creatorZubieta, J.L. (José L.)
dc.creatorRodriguez-Oroz, M.C. (María Cruz)
dc.creatorLuquin, M.R. (María Rosario)
dc.creatorRichter, J.A. (José Ángel)
dc.creatorObeso, J.A. (José A.)
dc.date.accessioned2010-10-21T08:27:14Z-
dc.date.available2010-10-21T08:27:14Z-
dc.date.issued2009-04-23-
dc.identifier.citationCollantes M, Prieto E, Penuelas I, Blesa J, Juri C, Marti-Climent JM, et al. New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification. Neuroimage 2009 Aug 15;47(2):533-539.es_ES
dc.identifier.issn1053-8119-
dc.identifier.urihttps://hdl.handle.net/10171/13574-
dc.description.abstractNormalization of neuroimaging studies to a stereotaxic space allows the utilization of standard volumes of interest (VOIs) and voxel-based analysis (SPM). Such spatial normalization of PET and MRI studies requires a high quality template image. The aim of this study was to create new MRI and PET templates of 18F-DOPA and 11C-(+)-α-dihydrotetrabenazine (11C-DTBZ) of the Macaca fascicularis brain, an important animal model of Parkinson's disease. MRI template was constructed as a smoothed average of the scans of 15 healthy animals, previously transformed into the space of one representative MRI. In order to create the PET templates, 18F-DOPA and 11C-DTBZ PET of the same subjects were acquired in a dedicated small animal PET scanner and transformed to the created MRI template space. To validate these templates for PET quantification, parametric values obtained with a standard VOI-map applied after spatial normalization to each template were statistically compared to results computed using individual VOIs drawn for each animal. The high correlation between both procedures validated the utilization of all the templates, improving the reproducibility of PET analysis. To prove the utility of the templates for voxel-based quantification, dopamine striatal depletion in a representative monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was assessed by SPM analysis of 11C-DTBZ PET. A symmetric reduction in striatal 11C-DTBZ uptake was detected in accordance with the induced lesion. In conclusion, templates of M. fascicularis brain have been constructed and validated for reproducible and automated PET quantification. All templates are electronically available via the internet.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNew MRIfores_ES
dc.subjectPETes_ES
dc.subject18F-DOPAes_ES
dc.subject11C-(+)-α-dihydrotetrabenazine templateses_ES
dc.subjectMacaca fascicularis neuroimaginges_ES
dc.subjectAdvantages to improve quantificationes_ES
dc.titleNew MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantificationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2009.04.078es_ES

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