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A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change
Authors: Razquin, C. (Cristina)
Martinez, J.A. (José Alfredo)
Martinez-Gonzalez, M.A. (Miguel Ángel)
Salas-Salvado, J. (Jordi)
Estruch, R. (Ramon)
Marti, A. (Amelia)
Keywords: Dieta mediterránea
Mediterranean diet
Peso corporal
Body weight
Issue Date: 2010
Publisher: Springer
Publisher version: DOI:10.1007/s00394-009-0090-2 (The original publication is available at
ISSN: 1436-6207
Citation: Razquin C, Martinez JA, Martinez-Gonzalez MA, Bes-Rastrollo M, Fernandez-Crehuet J, Marti A. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. Int.J.Obes.(Lond) 2010 Feb;34(2):266-272.
Purpose Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients Subjects and methods A total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G and +276 G/T polymorphisms was done. Results GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B=1.399; B=0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction=0.053). Conclusion Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.
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Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Farmacia - CAFT - Artículos de revista
DA - Medicina - MPSP -Artículos de revista

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