(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Medicina > Departamento de Medicina Preventiva y Salud Pública > DA - Medicina - MPSP -Artículos de revista >

Dietary Fat Intake and the Risk of Depression: The SUN Project
Autor(es) : Sanchez-Villegas, A. (Almudena)
Verberne, L. (Lisa)
Irala, J. (Jokin) de
Ruiz-Canela, M. (Miguel)
Toledo, E. (Estefania)
Serra-Majem, L. (Lluis)
Martinez-Gonzalez, M.A. (Miguel Ángel)
Palabras clave : Nutrición y dietética
Depression
Fat intake
Diet
Depresión
Ingesta de grasas
Dieta
Fecha incorporación: 26-ene-2011
Editorial : Public Library of Science
Versión del editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016268#abstract0
ISSN: 1932-6203
Cita: Sanchez-Villegas A, Verberne L, De Irala J, Rui­z-Canela M, Toledo E, Serra-Majem L, et al. Dietary Fat Intake and the Risk of Depression: The SUN Project. PLoS ONE 2011 01/26;6(1):e16268.
Resumen
Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship. Objective: To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population. Material and Methods: Prospective cohort study (1999–2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats. Results: During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82–1.43), 1.17 (0.88–1.53), 1.28 (0.97–1.68), 1.42 (1.09–1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake. Conclusions: A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake.
Enlace permanente: http://hdl.handle.net/10171/15932
Aparece en las colecciones: DA - Medicina - MPSP -Artículos de revista

Ficheros en este registro:
Fichero:  MartinezPlosOne.pdf
Descripción: 
Tamaño:  179,3 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.