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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Farmacia y Tecnología Farmacéutica > DA - Farmacia - Tecnología Farmacéutica - Artículos de revista >

Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis.
Autor(es) : Gomez, S. (Sara)
Gamazo, C. (Carlos)
San-Roman, B. (Beatriz)
Ferrer, M. (Marta)
Sanz, M.L. (María Luisa)
Espuelas, S. (Socorro)
Irache, J.M. (Juan Manuel)
Palabras clave : Nanoparticles
Adjuvant
Lipopolysaccharide
Ovalbumin
Anaphylactic shock
Immunotherapy
Gantrez
Fecha incorporación: 2008
Editorial : Elsevier
Versión del editor: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6C-4SP3SN8-3&_user=766132&_coverDate=11%2F30%2F2008&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000042418&_version=1&_urlVersion=0&_userid=766132&md5=0b1968678bcb77c9cd41e521c6217d54&searchtype=a
ISSN: 0939-6411
Cita: Gomez S, Gamazo C, San Roman B, Ferrer M, Sanz ML, Espuelas S, et al. Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis. Eur J Pharm Biopharm 2008 Nov;70(3):711-717.
Resumen
Background: Specific immunotherapy implies certain drawbacks which could be minimized by the use of good adjuvants, capable of amplifying the appropriate immune response with minimal adverse effects. Objective: To evaluate the adjuvant capacity of the association of the rough lipopolysaccharide of Brucella ovis with Gantrez® AN nanoparticles. Methods: Ovalbumin (allergen model)-containing Gantrez® AN nanoparticles with either encapsulated or coated lipopolysaccharide were prepared and administered intradermally to BALB/c mice in order to evaluate the immune response. Pre-sensitized BALB/c mice were also administered with the formulations and they were challenged with an intraperitoneal injection of ovalbumin. Anaphylactic symptoms, including mortality rates, were evaluated after the challenge. Results: The intradermal administration of mice with ovalbumin-containing nanoparticles elicited high and sustained specific IgG1 and IgG2a responses. However, the only treatment that totally protected the mice from death after the challenge of induced allergic mice to ovalbumin, required the co-administration of lipopolysaccharide entrapped inside the nanoparticles. Conclusion: Gantrez® AN nanoparticles with entrapped rough lipopolysaccharide of Brucella ovis protected ovalbumin pre-sensitized BALB/c mice from anaphylactic shock. Clinical Implications: These results are highly suggestive for the valuable use of Gantrez® nanoparticles combined with lipopolysaccharide of Brucella ovis in immunotherapy with allergens.
Enlace permanente: http://hdl.handle.net/10171/17368
Aparece en las colecciones: DA - Farmacia - Tecnología Farmacéutica - Artículos de revista
DA - Medicina - Microbiología y Parasitología - Artículos de revista

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Fichero:  Gomez_Manuscript_Correc.pdf
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