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dc.creatorMargareto, J. (Javier)
dc.creatorGomez-Ambrosi, J. (Javier)
dc.creatorMarti, A. (Amelia)
dc.creatorMartinez, J.A. (José Alfredo)
dc.date.accessioned2011-04-05T10:39:15Z-
dc.date.available2011-04-05T10:39:15Z-
dc.date.issued2001-
dc.identifier.citationMargareto J, Gomez-Ambrosi J, Marti A, Martinez JA. Time-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue genes. Biochem Biophys Res Commun 2001 Apr 27;283(1):6-11.es_ES
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10171/17499-
dc.description.abstractWhite adipose tissue development is regulated by many factors, including the energy content of food and the genetic background. Nevertheless, little is known about possible differential effects of high-fat palatable diets when fed for short or long-time periods. Thus, the expression of certain genes involved with lipid metabolism (peroxisome proliferator-activated receptor gamma, PPARγ2; retinoic receptors; fatty acid binding protein, aP2 and uncoupling proteins, UCP) may be affected by those dietary manipulations (high-energy-yielding diet and time duration of feeding). High-fat feeding for 8 days decreased mRNA UCP3 levels compared to control fed animals, while feeding for 30 days increased them over controls. Similar findings occurred for PPARγ2 and aP2. Furthermore, statistically significant associations were found among PPARγ2, aP2 and UCP3 mRNA levels. These data suggest a physiological time-dependent response seeking to prevent excessive fat deposition when animals are fed for short-term with a high amount of dietary fat, which was followed by an adaptive period to the high-energy content of diet throughout a coregulation among certain lipid metabolism related genes: PPARγ2, aP2, UCP3.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectWhite adipose tissuees_ES
dc.subjectHigh-energy dietes_ES
dc.subjectThermogenesises_ES
dc.subjectPeroxisome proliferator-activated receptor γes_ES
dc.subjectFatty acid binding proteines_ES
dc.subjectUncoupling proteinses_ES
dc.titleTime-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue geneses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversiondoi:10.1006/bbrc.2001.4733es_ES

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