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Multipotent Adult Progenitor Cells (MAPC) contribute to hepatocarcinoma neovasculature
Authors: Barajas, M. (Miguel)
Franchi, F. (F.)
Clavel, C. (C.)
Aranguren, X.L. (Xabier L.)
Kramer, M.G. (María Gabriela)
Abizanda, G. (Gloria)
Merino, J. (Juana)
Moreno, C. (Cristina)
Garate, L. (Leire)
Guitart, A. (Anunciata)
Narvaiza, I. (Íñigo)
Gutierrez-Perez, M. (María)
Riezu-Boj, J.I. (José Ignacio)
Berasain, C. (Carmen)
Prieto, J. (Jesús)
Prosper, F. (Felipe)
Keywords: MAPC
Stem cell
Gene therapy
Issue Date: 2007
Publisher: Elsevier
Publisher version:
ISSN: 0006-291X
Citation: Barajas, M., Franchi, F., Clavel, C., Aranguer, K. L. et al.Biochem. biophys. res. commun. 2007; 364 (1): 92-99
The use of stem cells as a vehicle of therapeutic genes is an attractive approach for the development of new antitumoral strategies based on gene therapy. The aim of our study was to assess the potential of bone marrow-derived Multipotent Adult Progenitor Cells (rMAPCs) to differentiate in vitro and in vivo into endothelial cells and to be recruited to areas of tumor vasculogenesis. In vitro, rMAPCs obtained from Buffalo rats differentiated into cells expressing endothelial markers and demonstrated functional endothelial capacity. Intravenous injection of undifferentiated rMAPC transduced with a lentivirus expressing GFP in an orthotopic rat model of hepatocellular carcinoma, resulted in tumor recruitment of the injected cells and in vivo differentiation into endothelial cells in the tumor area with contribution to vasculogenesis. In summary, our results suggest that rMAPCs can be efficiently recruited by vascularized tumors and differentiate to endothelium and thus may represent a useful vehicle for delivery of therapeutic genes to sites of active tumor neovascularization.
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Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Oncobiología - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista
DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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