Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Fontalba, A. (A.) | |
| dc.creator | Real, P.J. (Pedro J.) | |
| dc.creator | Fernandez-Luna, J.L. (J.L.) | |
| dc.creator | Aguirre-Ena, X. (Xabier) | |
| dc.creator | Prosper-Cardoso, F. (Felipe) | |
| dc.creator | Richard, C. (Carlos) | |
| dc.date.accessioned | 2011-04-06T13:42:14Z | - |
| dc.date.available | 2011-04-06T13:42:14Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.citation | Fontalba, A., Real P. J., Fernández-Luna, J. L., Agirre, X. et al. Leukemia Research. 2006; 30: 1323–1326 | es_ES |
| dc.identifier.issn | 0145-2126 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/17548 | - |
| dc.description.abstract | Imatinib mesylate has recently been reported to have clinical activity in the treatment of polycythemia vera (PV), suggesting the involvement of one of the kinases targeted by this inhibitor, including c-Kit and PDGFR. Activating c-Kit mutations have been identified in patients with mastocytosis and other myeloid disorders such as acute myeloid leukemia. Thus, we wanted to analyze the presence of mutations of c-Kit in polycythemia vera patients. We found that 7 out of 20 patients carried missense mutations in the c-Kit gene whereas no sequence variation was detected in 15 healthy controls. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | C-Kit | es_ES |
| dc.subject | Polycythemia | es_ES |
| dc.subject | Vera | es_ES |
| dc.subject | Mutation | es_ES |
| dc.title | Identification of c-Kit gene mutations in patients with polycythemia vera | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/journal/01452126 | es_ES |
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