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|Relationship between lactose digestion, gastrointestinal transit time and symptoms in lactose malabsorbers after dairy consumption|
|Authors: ||Labayen, I. (Idoya)|
Forga, L. (Luis)
Gonzalez, A. (Álvaro)
Lenoir-Wijnkoop, I. (I.)
Nutr, R. (R.)
Martinez, J.A. (José Alfredo)
|Keywords: ||Lactose tolerance|
|Issue Date: ||2001|
|Publisher version: ||The definitive version is available at www3.interscience.wiley.com DOI: 10.1046/j.1365-2036.2001.00952.x|
|Citation: ||Labayen I, Forga L, Gonzalez A, Lenoir-Wijnkoop I, Nutr R, Martinez JA. Relationship between lactose digestion, gastrointestinal transit time and symptoms in lactose malabsorbers after dairy consumption. Aliment Pharmacol Ther 2001 Apr;15(4):543-549.|
Background: The relationship of symptoms with objective measurements, as well as some of the mechanisms involved in lactose tolerance after yoghurt consumption,
Methods: The trial had a double-blind design in which 22 lactose malabsorbers received 25 g daily lactose in fresh (living bacteria > 108 cfu/g) yoghurt or heated (< 102 cfu/g) yoghurt for 15 days, followed by a crossover
(15 days) after a wash-out period (14 days). The lactose digestion was determined by the breath H2 test, the gastric emptying (GE) with a 13C-acetate breath test and the revealed transit time (OCTT) by 15N-lactoseureide test. Subjects reported their gastrointestinal symptoms (GIS) in a validated questionnaire.
Results: Breath H2 test indicated more effective lactose digestion after fresh yoghurt intake. The OCTT was shorter after heated yoghurt ingestion as compared with
the fresh. There was lower severity of GIS (P < 0.05) after fresh yoghurt intake, and this showed an inverse correlation with OCTT (P < 0.05).
Conclusions: Delayed orocoecal transit time was associated with fewer gastrointestinal symptoms. The improved lactose digestion and tolerance of fresh yoghurt should be mainly attributed to the presence of living bacteria.
|Permanent link: ||http://hdl.handle.net/10171/17571|
|Appears in Collections:||DA - Farmacia - CAFT - Artículos de revista|
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