Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
Palabras clave : 
Cancer testis antigens
HAGE
Hypomethylation
CML
Fecha incorporación: 
2007
Editorial : 
Pensiero Scientifico / Ferrata Storti Foundation
ISSN: 
0390-6078
Cita: 
Román-Gómez, J., Jiménez-Velasco, A., Agirre, X., Castillejo, J. A. et al... Haematologica 2007; 92: 153-162
Resumen
Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies.

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2007_Haematologica_Roman-Gomez_Epigenetic regulation of human cancer testis antigen gene, HAGE, in CML.pdf
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