Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia

Roman-Gomez, J. (José); Jimenez-Velasco, A. (A.); Aguirre-Ena, X. (Xabier); Castillejo, J.A. (J.A.); Navarro, G. (Germán); San-Jose-Eneriz, E. (Edurne); Garate, L. (Leire); Cordeu, L. (Lucía); Cervantes, F. (F.); Prosper-Cardoso, F. (Felipe); Heiniger, A. (A.); Torres, A. (Antonio)

Keywords:

Cancer testis antigens
HAGE
Hypomethylation
CML

Issue Date:

2007

Publisher:

Pensiero Scientifico / Ferrata Storti Foundation

ISSN:

0390-6078

Citation:

Román-Gómez, J., Jiménez-Velasco, A., Agirre, X., Castillejo, J. A. et al... Haematologica 2007; 92: 153-162

Abstract

Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies.

URI:

https://hdl.handle.net/10171/17646

Appears in Collections:

DA - CIMA - Hemato-oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Medicina regenerativa - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista

Files in This Item: