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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Saez, B. (Borja) | - |
dc.creator | Martin-Subero, J.I. (Jose Ignacio) | - |
dc.creator | Odero, M.D. (Maria Dolores) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Cigudosa, J.C. (Juan Cruz) | - |
dc.creator | Schoch, R. (Robert) | - |
dc.creator | Calasanz-Abinzano, M.J. (Maria Jose) | - |
dc.creator | Siebert, R. (Reiner) | - |
dc.date.accessioned | 2011-04-13T14:00:27Z | - |
dc.date.available | 2011-04-13T14:00:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Sáez, B., Martín-Subero, J. I., Odero, M. D., Prósper, F., et al. Oncol. Rep. 2007; 18: 1099-1106 | es_ES |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://hdl.handle.net/10171/17697 | - |
dc.description.abstract | Specific chromosomal abnormalities such as chromosome 13 deletions and some translocations affecting the immunoglobulin heavy chain (IGH) gene, namely t(4;14)(p16;q32) and t(14;16)(q32;q23) have been associated with an adverse prognosis in multiple myeloma. Conventional cytogenetic techniques fail to detect these aberrations in the majority of cases. Thus, we have developed a novel set of interphase fluorescence in situ hybridization (I-FISH) assays targeting those regions frequently lost on chromosome 13 as well as those oncogenes most recurrently involved in translocations with the IGH locus in multiple myeloma, i.e. IRTA1/2 (1q21), FGFR3/MMSET (4p16), CCND3 (6p21), IRF4 (6p25), CCND1 (11q13), MAF (16q23), and MAFB (20q12). The probes were combined in a multicolor fashion to develop novel multicolor I-FISH (MI-FISH) assays, whose validity and applicability was evaluated in negative controls and in a series of 13 plasma cell neoplasias. Additionally, a combination of the novel MI-FISH assays with staining for the plasma cell-specific antigen VS38c by means of multicolor FICTION (M-FICTION, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms) allowed us to selectively analyze the plasma cell compartment, and thereby to increase the assay sensitivity. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Spandidos | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Multiple myeloma | es_ES |
dc.subject | In situ hybridization | es_ES |
dc.subject | Fluorescence immunophenotyping | es_ES |
dc.subject | Interphase cytogenetics | es_ES |
dc.title | Multicolor interphase cytogenetics for the study of plasma cell dyscrasias | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.spandidos-publications.com/or/ | es_ES |
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