Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia

Roman-Gomez, J. (José); Jimenez-Velasco, A. (A.); Aguirre-Ena, X. (Xabier); Castillejo, J.A. (J.A.); Navarro, G. (Germán); San-Jose-Eneriz, E. (Edurne); Garate, L. (Leire); Cordeu, L. (Lucía); Cervantes, F. (F.); Prosper-Cardoso, F. (Felipe); Heiniger, A. (A.); Torres, A. (Antonio)

Keywords:

LINE1
Alu
Satellite-alpha
Satellite-2
Hypomethylation
CML

Issue Date:

2007

Publisher:

Elsevier

Publisher Version:

http://www.sciencedirect.com/science/journal/01452126

ISSN:

0145-2126

Citation:

Román-Gómez, J., Jiménez-Velasco, A., Agirre, X., Castillejo, J. A. et al. Leukemia Research 2007; 31 (11): 1521-1528

Abstract

Repetitive elements are heavily methylated in normal tissues, but hypomethylated in malignant tissues, driving the global genomic hypomethylation found in cancer. This hypomethylation results in chromosomal instability, a well-characterized feature of the advanced phases of chronic myeloid leukemia (CML). We investigated methylation changes of DNA repetitive elements (LINE1, Alu, Satellite-alpha and Satellite-2) during the progression of CML from chronic phase (CP) to blast crisis (BC). CP-CML samples were significantly more hypomethylated for all repetitive sequences compared with normal samples. Furthermore, a more profound level of hypomethylation was observed among BC samples compared with CP samples. Our data suggest that repetitive DNA hypomethylation are closely associated with CML progression.

URI:

https://hdl.handle.net/10171/17700

Appears in Collections:

DA - CIMA - Hemato-oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Medicina regenerativa - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista

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