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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Effects of Trecadrine, a beta3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes
Authors: Moreno-Aliaga, M.J. (María Jesús)
Martinez, J.A. (José Alfredo)
Stanhope, K.L. (K.L.)
Fernandez-Otero, M.P. (María Pilar)
Havel, P.J. (P. J.)
Keywords: Beta3-adrenoceptor
Leptin
Insulin-mediated glucose metabolism
Lipogenesis
Lactate
Lipolysis
Issue Date: 2002
Publisher: Nature Publishing Group
Publisher version: http://www.nature.com/ijo/journal/v26/n7/full/0802003a.html
ISSN: 0307-0565
Citation: Moreno-Aliaga MJ, Martinez JA, Stanhope KL, Fernandez-Otero MP, Havel PJ. Effects of Trecadrine, a beta3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes. Int J Obes Relat Metab Disord 2002 Jul;26(7):912-919.
Abstract
Objective: Leptin, a hormone produced in adipocytes, is a key signal in the regulation of food intake and energy expenditure. beta-Adrenergic agonists have been shown to inhibit leptin gene expression and leptin secretion. The mechanisms underlying the inhibitory effects of beta-adrenergic agonists have not been established. In this study, we examined the effects of TrecadrineÒ, a novel beta3-adrenergic agonist, on basal and insulin-stimulated leptin secretion in isolated rat adipocytes. Because insulin-stimulated glucose metabolism is an important regulator of leptin expression and secretion by the adipocytes, the effects of Trecadrine on indices of adipocyte metabolism were also examined. Measurements: Isolated adipocytes were incubated with Trecadrine (10-8-10-4 M) in the absence or presence of i