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|NADPH Oxidase–Dependent Superoxide Production Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Atherosclerotic Disease|
|Authors: ||Zalba, G. (Guillermo)|
Beloqui, O. (Óscar)
San-Jose, G. (Gorka)
Moreno, M.U. (María Ujué)
Fortuño, A. (Ana)
Diez, J. (Javier)
|Issue Date: ||2005|
|Publisher: ||American Heart Association|
|Publisher version: ||http://atvb.ahajournals.org/cgi/content/full/25/7/1452|
|Citation: ||Zalba G, Beloqui O, San José G, Moreno MU, Fortuño A, Díez J. NADPH oxidase-dependent superoxide production is associated with carotid intima-media thickness in subjects free of clinical atherosclerotic disease. Arterioscler Thromb Vasc Biol 2005 Jul;25(7):1452-1457|
Objective—Oxidative stress plays a critical role in the pathogenesis of atherosclerosis. The NADPH oxidase constitutes the
main source of superoxide in phagocytic and vascular cells. This study aimed to investigate the levels of NADPH
oxidase–mediated superoxide production in phagocytic cells and the association between phagocytic superoxide
production and carotid intima-media thickness (IMT), a surrogate marker of asymptomatic atherosclerosis.
Methods and Results—NADPH oxidase–mediated superoxide production was determined by a chemiluminescence assay
using lucigenin and associated with IMT for 184 asymptomatic subjects free of overt clinical atherosclerotic disease.
Compared with individuals in the lowest tertile of superoxide production, those in the upper tertile ( 20 counts/sec)
showed significantly higher IMT (P 0.05). In correlation analysis, a positive relationship was found between
superoxide production and carotid IMT. Superoxide production also correlated positively (P 0.05) with body mass
index (BMI). In multivariate analysis, the association of superoxide production with carotid IMT remained significant
after adjustment for age, sex, systolic blood pressure, BMI, triglycerides, glucose, and smoking.
Conclusions—In a population sample of adults without clinically overt atherosclerotic disease, increased NADPH oxidase
activity was associated with enhanced carotid IMT, suggesting a relationship between phagocytic NADPH oxidase–
mediated oxidative stress and the development of atherosclerosis.
|Permanent link: ||http://hdl.handle.net/10171/17794|
|Appears in Collections:||DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista|
DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista
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