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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Multipotent adult progenitor cells sustain function of ischemic limbs in mice
Authors: Aranguren, X.L. (Xabier L.)
McCue, J.D. (Jonathan D.)
Hendrickx, B. (B.)
Zhu, X.H. (Xiao Hong)
Du, F. (F.)
Chen, E. (E.)
Pelacho, B. (Beatriz)
Peñuelas, I. (Iván)
Abizanda, G. (Gloria)
Uriz, M. (Maialen)
Frommer, S.A. (S. A.)
Ross, J.J. (John J.)
Schroeder, B.A. (Betsy A.)
Seaborn, M.S. (Meredith S.)
Adney, J. (Josuah R.)
Hagenbrock, J. (J.)
Harris, N.H. (N. H.)
Zhang, Y. (Yi)
Zhang, X. (Xiaoliang)
Nelson-Holte, M. (Molly)
Jiang, Y. (Y.)
Billiau, A.D. (A.D.)
Chen, W. (W.)
Prosper, F. (Felipe)
Verfaillie, C.M. (Catherine M.)
Luttun, A. (Aernout)
Keywords: Materias Investigacion::Ciencias de la Salud::Oncología
Issue Date: 2008
Publisher: American Society for Clinical Investigation
Publisher version:
ISSN: 0021-9738
Citation: Aranguren, X. L., McCue, J. D., Hendrickx, B., Zhu, X.-H. et al. J Clin Invest. 2008; 118(2): 505–514
Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP), and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients.
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Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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