(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Enfermedad vascular hipertensiva > DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista >

Oxidative stress and vascular remodelling
Autor(es) : Fortuño, A. (Ana)
San-Jose, G. (Gorka)
Moreno, M.U. (María Ujué)
Diez, J. (Javier)
Zalba, G. (Guillermo)
Palabras clave : NADPH oxidase
Oxidative stress
Fecha incorporación: jul-2005
Editorial : Wiley-Blackwell
Versión del editor: http://ep.physoc.org/content/90/4/457.full
ISSN: 1469-445X
Cita: Fortuño A, San José G, Moreno MU, Díez J, Zalba G. Oxidative stress and vascular remodelling. Exp Physiol 2005 Jul;90(4):457-462
Resumen
Oxidative stress plays an important role in the pathophysiology of vascular diseases. Reactive oxygen species, especially superoxide anion and hydrogen peroxide, are important signalling molecules in cardiovascular cells. Enhanced superoxide production increases nitric oxide inactivation and leads to an accumulation of peroxynitrites and hydrogen peroxide. Reactive oxygen species participate in growth, apoptosis and migration of vascular smooth muscle cells, in the modulation of endothelial function, including endothelium-dependent relaxation and expression of proinflammatory phenotype, and in the modification of the extracellular matrix. All these events play important roles in vascular diseases such as hypertension, suggesting that the sources of reactive oxygen species and the signalling pathways that theymodifymay represent important therapeutic targets. Potential sources of vascular superoxide production include NADPH-dependent oxidases, xanthine oxidases, lipoxygenases, mitochondrial oxidases and nitricoxide synthases. Studies performedduring the last decadehave shownthatNADPHoxidase is the most important source of superoxide anion in phagocytic and vascular cells. Evidence from experimental animal and human studies suggests a significant role ofNADPHoxidase activation in the vascular remodelling and endothelial dysfunction found in cardiovascular diseases.
Enlace permanente: http://hdl.handle.net/10171/17835
Aparece en las colecciones: DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista

Ficheros en este registro:
Fichero:  2005 Fortuño et al Exp Physiol 2005.pdf
Descripción: 
Tamaño:  264,93 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.