Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Fortuño, A. (Ana) | - |
dc.creator | Rodriguez, A. (Amaia) | - |
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.creator | Muñiz, P. (Paula) | - |
dc.creator | Salvador, J. (Javier) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.date.accessioned | 2011-04-20T14:16:04Z | - |
dc.date.available | 2011-04-20T14:16:04Z | - |
dc.date.issued | 2002-09 | - |
dc.identifier.citation | Fortuño A, Rodríguez A, Gómez-Ambrosi J, Muñiz P, Salvador J, Díez J, et al. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology 2002 Sep;143(9):3555-3560. | es_ES |
dc.identifier.issn | 1945-7170 | - |
dc.identifier.uri | https://hdl.handle.net/10171/17843 | - |
dc.description.abstract | Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult Wistar rats by RT-PCR. Immunocytochemistry and Western blot analysis further showed the expression of OB-R protein in VSMCs. The ANG II (10(-7) mol/liter)-induced increase in intracellular Ca(2+) was blocked (P < 0.01) by leptin (10(-8) mol/liter). Moreover, in calcium-free buffer leptin was able to inhibit 65% of the ANG II-induced calcium release from intracellular stores. In endothelium-denuded aortic rings from adult Wistar rats no effect of leptin on basal tension was observed. However, the ANG II-induced isometric contraction was reduced (P < 0.05) by leptin (10(-8) mol/liter). The experiments were also performed in age- and sex-matched Zucker rats, in which no effect of leptin on ANG II-induced calcium increase and vasoconstriction was observed. It is concluded that leptin blocks the vasoconstrictor action of ANG II and inhibits the ANG II-induced increase in intracellular Ca(2+) in VSMCs through OB-Rb. These findings provide new insight into the physiological effects of leptin on blood pressure regulation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Endocrine Society | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Angiotensin II | es_ES |
dc.subject | Leptin | es_ES |
dc.subject | Vasoconstriction | es_ES |
dc.subject | Aorta | es_ES |
dc.title | Leptin Inhibits Angiotensin II-Induced Intracellular Calcium Increase and Vasoconstriction in the Rat Aorta | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://endo.endojournals.org/cgi/content/full/143/9/3555 | es_ES |
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