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dc.creatorSan-Jose, G. (Gorka)
dc.creatorFortuño, A. (Ana)
dc.creatorMoreno, M.U. (María Ujué)
dc.creatorRobador, P.A. (Pablo A.)
dc.creatorBidegain, J. (J.)
dc.creatorVaro, N. (Nerea)
dc.creatorBeloqui, O. (Óscar)
dc.creatorDiez-Martinez, J. (Javier)
dc.creatorZalba, G. (Guillermo)
dc.date.accessioned2011-05-19T08:39:17Z-
dc.date.available2011-05-19T08:39:17Z-
dc.date.issued2009-
dc.identifier.citationSan Jose G, Fortuño A, Moreno MU, Robador PA, Bidegain J, Varo N, et al. The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension. Clin Sci (Lond) 2009 Feb;116(3):233-240.es_ES
dc.identifier.issn1470-8736-
dc.identifier.urihttp://hdl.handle.net/10171/18012-
dc.description.abstractThe objective of the present study was to analyse the influence of the ACE (angiotensin-converting enzyme) gene I/D (insertion/deletion) polymorphism on NADPH oxidase-dependent O(2)(*-) (superoxide radical) production, and to investigate the clinical implication of this association in hypertensive subjects. A case-control study was performed in a random sample of the general population composed of 189 normotensive subjects and 223 hypertensive subjects. The ACE polymorphism was determined by PCR. NADPH oxidase-dependent O(2)(*-) production was quantified in phagocytic cells by chemiluminescence. MMP-9 (matrix metalloproteinase-9), a marker of atherosclerosis previously reported to be associated with NADPH oxidase overactivity, was quantified by ELISA in plasma samples. The distribution of genotypes was in Hardy-Weinberg equilibrium. The I/D polymorphism was not associated with hypertension. NADPH oxidase-dependent O(2)(*-) production was significantly higher in D/D (deletion/deletion) than in I/I (insertion/insertion) and I/D, both in normotensive and hypertensive subjects. Interestingly, plasma levels of angiotensin II were significantly higher in D/D than in I/I and I/D, both in normotensive and hypertensive subjects. Plasma levels of MMP-9 and systolic blood pressure values were significantly higher in D/D than in I/I and I/D hypertensive subjects, whereas no differences were found among genotypes in normotensive subjects. Interestingly, NADPH oxidase-dependent O(2)(*-) production positively associated with plasma MMP-9 levels in hypertensive subjects, which remained significant after adjustment for age and gender. In conclusion, in the present study we have reported for the first time an association of the D/D genotype of the ACE I/D polymorphism with phagocytic NADPH oxidase-mediated O(2)(*-) overproduction. Within the group of hypertensive patients, D/D cases also associated with increased blood pressure values and with enhanced plasma levels of MMP-9.es_ES
dc.language.isoenges_ES
dc.publisherPortland Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectAngiotensin-converting enzyme (ACE)es_ES
dc.subjectEssential hypertensiones_ES
dc.subjectI/D polymorphismes_ES
dc.subjectMatrix metalloproteinase-9 (MMP-9)es_ES
dc.subjectNADPH oxidasees_ES
dc.subjectSuperoxidees_ES
dc.titleThe angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.clinsci.org/cs/116/cs1160233.htmes_ES

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