Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy
Palabras clave : 
Materias Investigacion::Ciencias de la Salud::Oncología
Fecha de publicación: 
2009
Editorial : 
Wiley-Blackwell
ISSN: 
0041-1132
Cita: 
Perez-Ilzarbe, M., Diez-Campelo, M., Aranda, P., Tabera, S. et al. Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy.Transfusion 2009; 49 (9): 1901–1910
Resumen
Mesenchymal stem cells (MSCs) are multipotent stem cells. Based on their properties, several clinical trials have been designed to explore their potential therapeutic effect. Fetal calf serum (FCS, commonly used for in vitro expansion) is an undesirable source of xenogeneic antigens and bears the risk of transmitting contaminations. As an alternative for FCS, platelet lysate (PL) and both autologous and allogeneic human serum have been proposed. The aim of this study is to compare the culture of bone marrow (BM)- derived MSCs in the presence of different serum supplements to determine the effect on cell growth, differentiation potential, and immunologic function.

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