Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Martin, V. (Vanesa) | |
dc.creator | Aguirre-Ena, X. (Xabier) | |
dc.creator | Jimenez-Velasco, A. (A.) | |
dc.creator | San-Jose-Eneriz, E. (Edurne) | |
dc.creator | Cordeu, L. (Lucía) | |
dc.creator | Garate, L. (Leire) | |
dc.creator | Vilas, A. (Amaia) | |
dc.creator | Castillejo, J.A. (J.A.) | |
dc.creator | Heiniger, A. (A.) | |
dc.creator | Prosper-Cardoso, F. (Felipe) | |
dc.creator | Torres, A. (Antonio) | |
dc.creator | Roman-Gomez, J. (José) | |
dc.date.accessioned | 2011-06-01T14:22:05Z | - |
dc.date.available | 2011-06-01T14:22:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Martin, V., Agirre, X., Jimenez-Velasco, A., San Jose-Eneriz, E. et al. Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia. Cancer Scie 2008; 99 (9): 1865–1868 | es_ES |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18357 | - |
dc.description.abstract | The clinical significance of aberrant promoter methylation of the canonical Wnt pathway antagonist genes (sFRP1, sFRP2, sFRP4, sFRP5, Wif1, Dkk3, and Hdpr1) and also putative tumor-suppressor gene Wnt5a, belonging to the non-canonical Wnt signaling pathway, was investigated in a large series of 75 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia by methylationspecific polymerase chain reaction. At least one methylated gene was observed in cells from 66% (49/75) of patients (methylated group). Disease-free survival and overall survival at 9 years were 51 and 40%, respectively, for the unmethylated group and 3 and 2%, respectively, for the methylated group (both P < 0.0001). Multivariate analysis demonstrated that the Wnt methylation profile was an independent prognostic factor predicting disease-free survival (P = 0.007) and overall survival (P = 0.039). Abnormal DNA methylation of promoter-associated CpG islands in the Wnt signaling pathway is very common in Philadelphia chromosome-positive acute lymphoblastic leukemia and potentially defines subgroups with distinct clinical characteristics. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1111/j.1349-7006.2008.00884.x | es_ES |
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