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|Anti-idiotype antibodies in cancer treatment|
|Authors: ||Lopez-Diaz-de-Cerio, A. (Ascensión)|
Zabalegui, N. (Natalia)
Rodriguez-Calvillo, M. (Mercedes)
Inoges, S. (Susana)
Bendandi, M. (Maurizio)
|Issue Date: ||2007|
|Publisher: ||Nature Publishing Group|
|Publisher version: ||http://www.nature.com/onc/journal/v26/n25/full/1210371a.html|
|Citation: ||Lopez-Diaz de Cerio AL, Zabalegui N, Rodriguez-Calvillo M, Inoges S, Bendandi M. Anti-idiotype antibodies in cancer treatment. Oncogene 2007 May 28;26(25):3594-3602.|
As a cancer immunotherapy tool, idiotypes (Ids) have been used in different ways over the last three decades, depending on the actual human tumor cell target. It all started with passive, monoclonal, anti-Id antibody treatment of B-cell lymphoma, a setting in which results were tantalizing, but logistics unsustainable. It then moved toward the development of anti-Id vaccines for the treatment of the same tumors, a setting in which we have recently provided the first formal proof of principle of clinical benefit associated with the use of a human cancer vaccine. Meanwhile, it also expanded in the direction of exploiting the antigenic mimicry of some Ids with Id-unrelated, tumor-associated antigens for the immunotherapy of a number of solid tumors, a setting in which clinical results are still far from being consolidated. All in all, over the years Id-based immunotherapy has paved the way for a number of seminal therapeutic improvements for cancer patients, including the development of most if not all Id-unrelated monoclonal antibodies that have recently revolutionized the field.
|Permanent link: ||http://hdl.handle.net/10171/18717|
|Appears in Collections:||DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista|
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista
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