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Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
Authors: Radcliffe, C.M. (Catherine M.)
Arnold, J.N. (J.N.)
Suter, D.M. (David M.)
Wormald, M.R. (Mark R.)
Harvey, D.J. (D. J.)
Royle, L. (Louise)
Mimura, Y. (Yusuke)
Kimura, Y. (Y.)
Sim, R.B. (Robert B.)
Inoges, S. (Susana)
Rodriguez-Calvillo, M. (Mercedes)
Zabalegui, N. (Natalia)
Cerio, A. (A.L.) de
Potter, K. (Kathleen N.)
Mockridge, C.I. (C. Ian)
Dwek, R.A. (R. A.)
Bendandi, M. (Maurizio)
Rudd, P.M. (Pauline M.)
Stevenson, F.K. (Freda K.)
Keywords: Lymphoma, Follicular/immunology
Receptors, Antigen, B-Cell/chemistry
Issue Date: 2007
Publisher: American Society for Biochemistry and Molecular Biology
Publisher version:
ISSN: 1083-351X
Citation: Radcliffe CM, Arnold JN, Suter DM, Wormald MR, Harvey DJ, Royle L, et al. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. J Biol Chem 2007 Mar 9;282(10):7405-7415.
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their involvement in tumor pathogenesis. Analysis of the V region sugars from lymphoma-derived IgG/IgM reveals that they are mostly oligomannose and, remarkably, are located in the antigen-binding site, possibly precluding conventional antigen binding. The Fc region contains complex glycans, confirming that the normal glycan processing pathway is intact. Binding studies indicate that the oligomannose glycans occupying the V regions are accessible to mannose-binding lectin. These findings suggest a potential contribution to lymphoma pathogenesis involving antigen-independent interaction of surface immunoglobulin of the B-cell receptor with mannose-binding molecules of innate immunity in the germinal center.
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Appears in Collections:DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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