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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Inmunoterapia > DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista >

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
Autor(es) : Radcliffe, C.M. (Catherine M.)
Arnold, J.N. (J.N.)
Suter, D.M. (David M.)
Wormald, M.R. (Mark R.)
Harvey, D.J. (D. J.)
Royle, L. (Louise)
Mimura, Y. (Yusuke)
Kimura, Y. (Y.)
Sim, R.B. (Robert B.)
Inoges, S. (Susana)
Rodriguez-Calvillo, M. (Mercedes)
Zabalegui, N. (Natalia)
Cerio, A. (A.L.) de
Potter, K. (Kathleen N.)
Mockridge, C.I. (C. Ian)
Dwek, R.A. (R. A.)
Bendandi, M. (Maurizio)
Rudd, P.M. (Pauline M.)
Stevenson, F.K. (Freda K.)
Palabras clave : Lymphoma, Follicular/immunology
Receptors, Antigen, B-Cell/chemistry
Oligosaccharides/analysis
Fecha incorporación: 2007
Editorial : American Society for Biochemistry and Molecular Biology
Versión del editor: http://www.jbc.org/content/282/10/7405
ISSN: 1083-351X
Cita: Radcliffe CM, Arnold JN, Suter DM, Wormald MR, Harvey DJ, Royle L, et al. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. J Biol Chem 2007 Mar 9;282(10):7405-7415.
Resumen
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their involvement in tumor pathogenesis. Analysis of the V region sugars from lymphoma-derived IgG/IgM reveals that they are mostly oligomannose and, remarkably, are located in the antigen-binding site, possibly precluding conventional antigen binding. The Fc region contains complex glycans, confirming that the normal glycan processing pathway is intact. Binding studies indicate that the oligomannose glycans occupying the V regions are accessible to mannose-binding lectin. These findings suggest a potential contribution to lymphoma pathogenesis involving antigen-independent interaction of surface immunoglobulin of the B-cell receptor with mannose-binding molecules of innate immunity in the germinal center.
Enlace permanente: http://hdl.handle.net/10171/18718
Aparece en las colecciones: DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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