3-Trifluoromethylquinoxaline N,N’-Dioxides as Anti-trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Derivatives and Mechanism of Action Studies
Keywords: 
Quinoxaline N,N´-Dioxide
T. cruzi
Leishmania
Issue Date: 
2011
Publisher: 
American Chemical Society
ISSN: 
0022-2623
Citation: 
Benitez D, Cabrera M, Hernandez P, Boiani L, Lavaggi ML, Di Maio R, et al. 3-Trifluoromethylquinoxaline N,N'-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Agents and Mechanism of Action Studies. J Med Chem 2011 May 26;54(10):3624-3636.
Abstract
As a fourth approach of quinoxaline N,N’-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing electron-withdrawing substituent in the 2-, 3-, 6-, and 7-positions rendered the most active compounds. With regard to these features, and taking in account their mammal-cytotoxicity, some trifluoromethylquinoxaline N,N’-dioxides have been proposed as candidates for further clinical studies. Consequently, mutagenicity and in vivo analyses were performed with one of the most promising derivatives. In addition, with regard to the mechanism of action studies, it was demonstrated that mitochondrial dehydrogenases are involved in the anti-T. cruzi activity of the most active derivatives.

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