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Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action
Authors: Berrade, L. (Luis)
Aisa, B. (Bárbara)
Ramirez, M.J. (María Javier)
Galiano, S. (Silvia)
Guccione, S. (S.)
Moltzau, L.R. (Lise Roman)
Levy, F.O. (Finn Olav)
Nicoletti, F. (Ferdinando)
Battaglia, G. (G.)
Molinaro, G. (Gemma)
Aldana, I. (Ignacio)
Monge, A. (Antonio)
Perez-Silanes, S. (Silvia)
Keywords: Depression
5-HT7 receptors
Dual compounds
Forced swimming test
Issue Date: 2011
Publisher: American Chemical Society
Publisher version:
ISSN: 0022-2623
Citation: Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, et al. Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem 2011 Apr 28;54(8):3086-3090.
We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
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Appears in Collections:DA - Farmacia - Orgánica - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - Farmacia - Farmacología - Artículos de revista

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