Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Berrade, L. (Luis) | - |
| dc.creator | Aisa, B. (Bárbara) | - |
| dc.creator | Ramirez, M.J. (María Javier) | - |
| dc.creator | Galiano, S. (Silvia) | - |
| dc.creator | Guccione, S. (S.) | - |
| dc.creator | Moltzau, L.R. (Lise Roman) | - |
| dc.creator | Levy, F.O. (Finn Olav) | - |
| dc.creator | Nicoletti, F. (Ferdinando) | - |
| dc.creator | Battaglia, G. (G.) | - |
| dc.creator | Molinaro, G. (Gemma) | - |
| dc.creator | Aldana, I. (Ignacio) | - |
| dc.creator | Monge, A. (Antonio) | - |
| dc.creator | Pérez-Silanes, S. (Silvia) | - |
| dc.date.accessioned | 2011-07-04T12:28:06Z | - |
| dc.date.available | 2011-07-04T12:28:06Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.citation | Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, et al. Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem 2011 Apr 28;54(8):3086-3090. | es_ES |
| dc.identifier.issn | 0022-2623 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/18726 | - |
| dc.description.abstract | We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | American Chemical Society | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | Depression | es_ES |
| dc.subject | Benzo[b]thiophene | es_ES |
| dc.subject | Serotonin | es_ES |
| dc.subject | 5-HT7 receptors | es_ES |
| dc.subject | SERT | es_ES |
| dc.subject | Dual compounds | es_ES |
| dc.subject | Forced swimming test | es_ES |
| dc.subject | Fluoxetine | es_ES |
| dc.title | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.identifier.doi | http://dx.doi.org/10.1021/jm2000773 | es_ES |
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