Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Torres, E. (Enrique) | - |
dc.creator | Moreno-de-Viguri, E. (Elsa) | - |
dc.creator | Ancizu, S. (Saioa) | - |
dc.creator | Barea, C. (Carlos) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.date.accessioned | 2011-07-04T18:19:04Z | - |
dc.date.available | 2011-07-04T18:19:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Torres E, Moreno E, Ancizu S, Barea C, Galiano S, Aldana I, et al. New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents. Bioorg Med Chem Lett 2011 Jun 15;21(12):3699-3703. | es_ES |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://hdl.handle.net/10171/18732 | - |
dc.description.abstract | The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Anti-Tuberculosis agents | es_ES |
dc.subject | Quinoxaline 1,4-di-N-oxide derivatives | es_ES |
dc.subject | Isoniazid | es_ES |
dc.subject | Microwave assisted synthesis | es_ES |
dc.subject | Druglikeness | es_ES |
dc.title | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.bmcl.2011.04.072 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.