Rodriguez Calvillo M, Inoges S, Lopez Diaz de Cerio A, Zabalegui N, Panizo C, Hernandez M, et al. Past, present and future of anti-idiotype vaccination. Rev Med Univ Navarra 2004 Jul-Sep;48(3):14-23.
Cancer vaccines are conceived as therapeutic tools, in contrast to the
prophylactic vaccines used to fight against infectious diseases. Among
the most potent therapeutic vaccines, anti-idiotype vaccination is directed
against the tumor idiotype, the only well-characterized tumor
antigen displayed in neoplastic B-cells. Anti-idiotype vaccines have
demonstrated clinical benefit against follicular lymphoma and are
currently being evaluated in two different phase III clinical trials.
Additional emerging strategies, which include the use of dendritic
cells and the production of vaccines via molecular means will surely
allow us to draw important conclusions concerning the treatment of