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dc.creatorBastarrika, G. (Gorka)-
dc.creatorGarcia-Velloso, M. J. (María José)-
dc.creatorLozano, M.D. (María Dolores)-
dc.creatorMontes, U. (Usúa)-
dc.creatorTorre, W. (Wenceslao)-
dc.creatorRodriguez-Spiteri, N. (Natalia)-
dc.creatorCampo, A. (Arantza)-
dc.creatorSeijo, L. (Luis)-
dc.creatorAlcaide, A.B. (Ana Belén)-
dc.creatorPueyo, J. (Jesús)-
dc.creatorCano, D. (David)-
dc.creatorVivas, I. (Isabel)-
dc.creatorCosin, O. (Octavio)-
dc.creatorDomínguez-Echávarri, P.D. (Pablo Daniel)-
dc.creatorSerra, P. (Patricia)-
dc.creatorRichter, J.A. (José Ángel)-
dc.creatorMontuenga-Badia, L.M. (Luis M.)-
dc.creatorZulueta, J. (Javier)-
dc.date.accessioned2011-08-19T08:26:40Z-
dc.date.available2011-08-19T08:26:40Z-
dc.date.issued2005-
dc.identifier.citationBastarrika G, Garcia-Velloso MJ, Lozano MD, Montes U, Torre W, Spiteri N, et al. Early lung cancer detection using spiral computed tomography and positron emission tomography. Am J Respir Crit Care Med 2005 Jun 15;171(12):1378-1383.es_ES
dc.identifier.issn1535-4970-
dc.identifier.urihttps://hdl.handle.net/10171/18803-
dc.description.abstractRATIONALE: Lung cancer screening using computed tomography (CT) is effective in detecting lung cancer in early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. OBJECTIVE: To study the efficiency of a lung cancer protocol using spiral CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). METHODS: High-risk individuals underwent screening with annual spiral CTs. Follow-up CTs were done for noncalcified nodules of 5 mm or greater, and FDG-PET was done for nodules 10 mm or larger or smaller (> 7 mm), growing nodules. RESULTS: A total of 911 individuals completed a baseline CT study and 424 had at least one annual follow-up study. Of the former, 14% had noncalcified nodules of 5 mm or larger, and 3.6% had nodules of 10 mm or larger. Eleven non-small cell lung cancers (NSCLC) and one small cell lung cancer (SCLC) were diagnosed in the baseline study (prevalence rate, 1.32%), and two NSCLCs in the annual study (incidence rate, 0.47%). All NSCLCs (92% of prevalence cancers) were diagnosed in stage I (12 stage IA, 1 stage IB). FDG-PET was helpful for the correct diagnosis in 19 of 25 indeterminate nodules. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG-PET for the diagnosis of malignancy were 69, 91, 90, and 71%, respectively. However, the sensitivity and negative predictive value of the screening algorithm, which included a 3-month follow-up CT for nodules with a negative FDG-PET, was 100%. CONCLUSION: A protocol for early lung cancer detection using spiral CT and FDG-PET is useful and may minimize unnecessary invasive procedures for benign lesions.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Thoracic Societyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectChronic obstructive pulmonary diseasees_ES
dc.subjectLung neoplasmes_ES
dc.subjectPulmonary nodulees_ES
dc.subjectSmokinges_ES
dc.titleEarly lung cancer detection using spiral computed tomography and positron emission tomographyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://ajrccm.atsjournals.org/cgi/content/abstract/171/12/1378es_ES

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