Full metadata record
DC Field | Value | Language |
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dc.creator | Bastarrika, G. (Gorka) | - |
dc.creator | Garcia-Velloso, M. J. (María José) | - |
dc.creator | Lozano, M.D. (María Dolores) | - |
dc.creator | Montes, U. (Usúa) | - |
dc.creator | Torre, W. (Wenceslao) | - |
dc.creator | Rodriguez-Spiteri, N. (Natalia) | - |
dc.creator | Campo, A. (Arantza) | - |
dc.creator | Seijo, L. (Luis) | - |
dc.creator | Alcaide, A.B. (Ana Belén) | - |
dc.creator | Pueyo, J. (Jesús) | - |
dc.creator | Cano, D. (David) | - |
dc.creator | Vivas, I. (Isabel) | - |
dc.creator | Cosin, O. (Octavio) | - |
dc.creator | Domínguez-Echávarri, P.D. (Pablo Daniel) | - |
dc.creator | Serra, P. (Patricia) | - |
dc.creator | Richter, J.A. (José Ángel) | - |
dc.creator | Montuenga-Badia, L.M. (Luis M.) | - |
dc.creator | Zulueta, J. (Javier) | - |
dc.date.accessioned | 2011-08-19T08:26:40Z | - |
dc.date.available | 2011-08-19T08:26:40Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Bastarrika G, Garcia-Velloso MJ, Lozano MD, Montes U, Torre W, Spiteri N, et al. Early lung cancer detection using spiral computed tomography and positron emission tomography. Am J Respir Crit Care Med 2005 Jun 15;171(12):1378-1383. | es_ES |
dc.identifier.issn | 1535-4970 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18803 | - |
dc.description.abstract | RATIONALE: Lung cancer screening using computed tomography (CT) is effective in detecting lung cancer in early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. OBJECTIVE: To study the efficiency of a lung cancer protocol using spiral CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). METHODS: High-risk individuals underwent screening with annual spiral CTs. Follow-up CTs were done for noncalcified nodules of 5 mm or greater, and FDG-PET was done for nodules 10 mm or larger or smaller (> 7 mm), growing nodules. RESULTS: A total of 911 individuals completed a baseline CT study and 424 had at least one annual follow-up study. Of the former, 14% had noncalcified nodules of 5 mm or larger, and 3.6% had nodules of 10 mm or larger. Eleven non-small cell lung cancers (NSCLC) and one small cell lung cancer (SCLC) were diagnosed in the baseline study (prevalence rate, 1.32%), and two NSCLCs in the annual study (incidence rate, 0.47%). All NSCLCs (92% of prevalence cancers) were diagnosed in stage I (12 stage IA, 1 stage IB). FDG-PET was helpful for the correct diagnosis in 19 of 25 indeterminate nodules. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG-PET for the diagnosis of malignancy were 69, 91, 90, and 71%, respectively. However, the sensitivity and negative predictive value of the screening algorithm, which included a 3-month follow-up CT for nodules with a negative FDG-PET, was 100%. CONCLUSION: A protocol for early lung cancer detection using spiral CT and FDG-PET is useful and may minimize unnecessary invasive procedures for benign lesions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Thoracic Society | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Chronic obstructive pulmonary disease | es_ES |
dc.subject | Lung neoplasm | es_ES |
dc.subject | Pulmonary nodule | es_ES |
dc.subject | Smoking | es_ES |
dc.title | Early lung cancer detection using spiral computed tomography and positron emission tomography | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://ajrccm.atsjournals.org/cgi/content/abstract/171/12/1378 | es_ES |
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