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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Biomarcadores > DA - CIMA - Oncología - Biomarcadores - Artículos de Revista >

Targeting hypoxia and angiogenesis through HIF-1alpha inhibition
Authors: Diaz-Gonzalez, J.A. (Juan Antonio)
Russell, J. (James)
Rouzaut, A. (Ana)
Gil-Bazo, I. (Ignacio)
Montuenga, L.M. (Luis M.)
Keywords: Hypoxia
Molecular inhibitors
Targeted therapy
Molecular imaging
Molecular therapy
Issue Date: 2005
Publisher: Landes Bioscience
Publisher version:
ISSN: 1538-4047
Citation: Diaz-Gonzalez JA, Russell J, Rouzaut A, Gil-Bazo I, Montuenga L. Targeting hypoxia and angiogenesis through HIF-1alpha inhibition. Cancer Biol Ther 2005 Oct;4(10):1055-1062.
Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness, invasiveness, and resistance to radiotherapy and chemotherapy. Targeting HIF-1alpha is an attractive strategy, with the potential for disrupting multiple pathways crucial for tumor growth. We review recent findings on the potential efficacy of small molecules to downregulate HIF-1alpha. These promising drugs inhibit HIF-1alpha synthesis or transcriptional activity by blocking a variety of steps in several different signaling pathways. Blocking HIF-1alpha activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. This strategy could also improve the efficiency of established tumor therapies.
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Appears in Collections:DA - CIMA - Oncología - Microambiente tumoral - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista
DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Oncología - Biomarcadores - Artículos de Revista

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