Protection from Staphylococcus aureus mastitis associated with poly-N-acetyl beta-1,6 glucosamine specific antibody production using biofilm-embedded bacteria

Perez-Calvo, M.M. (M.M.); Prenafeta, A. (A.); Valle, J. (Jaione); Penades, J. (J.); Rota, C. (C.); Solano, C. (C.); Marco, J. (J.); Grillo, M.J. (María Jesús); Lasa, I. (Íñigo); Irache, J.M. (Juan Manuel); Maira-Litran, T. (T.); Jimenez-Barbero, J. (J.); Costa, L. (L.); Pier, G.B. (G.B.); Andres, D. (D.) de; Amorena, B. (Beatriz)

Keywords:

Staphylococcus aureus
poly-N-acetyl β-1,6 glucosamine
Antibody

Issue Date:

2009

Publisher:

Elsevier

ISSN:

0264-410X

Citation:

Perez MM, Prenafeta A, Valle J, Penades J, Rota C, Solano C, et al. Protection from staphylococcus aureus mastitis associated with poly-N-acetyl beta-1,6 glucosamine specific antibody production using biofilm-embedded bacteria. Vaccine. 2009 Apr 14;27(17):2379-86.

Abstract

Staphylococcus aureus vaccines based on bacterins surrounded by slime, surface polysaccharides coupled to protein carriers and polysaccharides embedded in liposomes administered together with non-biofilm bacterins confer protection against mastitis. However, it remains unknown whether protective antibodies are directed to slime-associated known exopolysaccharides and could be produced in the absence of bacterin immunizations. Here, a sheep mastitis vaccination study was carried out using bacterins, crude bacterial extracts or a purified exopolysaccharide from biofilm

URI:

https://hdl.handle.net/10171/19186

DOI:

http://dx.doi.org/10.1016/j.vaccine.2009.02.005

Appears in Collections:

DA - Farmacia - Tecnología Farmacéutica - Artículos de revista

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