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In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188
Authors: Espuelas, S. (Socorro)
Legrand, P. (P.)
Loiseau, P.M. (P.M.)
Bories, C. (C.)
Barratt, G. (G.)
Irache, J.M. (Juan Manuel)
Keywords: Leishmania donovani
Poloxamer 188
Amphotericin B Resistance
Issue Date: 2000
Publisher: American Society for Microbiology
Publisher version:
ISSN: 0066-4804
Citation: Espuelas S, Legrand P, Loiseau PM, Bories C, Barratt G, Irache JM. In vitro reversion of amphotericin B resistance in leishmania donovani by poloxamer 188. Antimicrob Agents Chemother. 2000 Aug;44(8):2190-2.
A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.
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