In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188

Espuelas, S. (Socorro); Legrand, P. (P.); Loiseau, P.M. (P.M.); Bories, C. (C.); Barratt, G. (G.); Irache, J.M. (Juan Manuel)

Authors:

Espuelas, S. (Socorro)

Irache, J.M. (Juan Manuel)

Keywords:

Leishmania donovani
Poloxamer 188
Amphotericin B Resistance

Issue Date:

2000

Publisher:

American Society for Microbiology

Publisher Version:

http://aac.asm.org/cgi/content/full/44/8/2190

ISSN:

0066-4804

Citation:

Espuelas S, Legrand P, Loiseau PM, Bories C, Barratt G, Irache JM. In vitro reversion of amphotericin B resistance in leishmania donovani by poloxamer 188. Antimicrob Agents Chemother. 2000 Aug;44(8):2190-2.

Abstract

A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.

URI:

https://hdl.handle.net/10171/19206

Appears in Collections:

DA - Farmacia - Tecnología Farmacéutica - Artículos de revista

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