Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopez-Moratalla, N. (Natalia) | - |
dc.creator | Lopez-Zabalza, M.J. (María Jesús) | - |
dc.creator | Subira, M.L. (María L.) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Perez-Mediavilla, L.A. (Luis Alberto) | - |
dc.creator | Santiago, E. (Esteban) | - |
dc.date.accessioned | 2011-11-09T12:28:56Z | - |
dc.date.available | 2011-11-09T12:28:56Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Lopez-Moratalla N, Lopez-Zabalza MJ, Subira ML, Borras-Cuesta F, Perez-Mediavilla A, Santiago E. Immunomodulation induced by synthetic peptides derived from Staphylococcus aureus protein A. Biochim Biophys Acta. 1994 Mar 31;1221(2):153-158. | es_ES |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19473 | - |
dc.description.abstract | Peptides from 10 to 22 amino acids containing sequences encompassed by Staphylococcus aureus protein A were synthesized. Some of these peptides, when present in cultures of lymphomononuclear cells from healthy donors or from cancer patients (melanoma, breast carcinoma, non-Hodgkin lymphoma and renal cell carcinoma) promoted: (i) changes in the phenotype of the lymphomononuclear population, (ii) stimulation of monocytes (release of IL-1 and TNF-alpha), and (iii) an increase in cytotoxicity against K562, Daudi and HT-29 cells. Isolated monocytes responded also to those peptides with a release of IL-1 and TNF alpha and an increase of cytotoxicity against HT-29 cells. It was found that the active peptides had the following structural pattern: a length of at least 15 amino-acid residues with a proline at position 6, valine, leucine, isoleucine, glycine, alanine or lysine at position 2, and glutamic or aspartic acid at position 11. Replacement of Pro at position 6 with any other residue turned the peptide inactive. Replacement of residues at positions 2 and 11 with amino-acid residues other than those required for activity resulted in compounds with a marked decrease in the immunomodulating properties described, or lacking these properties altogether. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Immunomodulatory peptide | es_ES |
dc.subject | Cytotoxicity | es_ES |
dc.subject | Tumor necrosis factor alfa | es_ES |
dc.subject | Interleukin 1 | es_ES |
dc.subject | Lymphomononuclear cell | es_ES |
dc.subject | Monocyte | es_ES |
dc.title | Immunomodulation induced by synthetic peptides derived from Staphylococcus aureus protein A | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/0167-4889(94)90007-8 | es_ES |
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