Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopez-Moratalla, N. (Natalia) | - |
dc.creator | Migliacio, M. (Marco) | - |
dc.creator | Lopez-Zabalza, M.J. (María Jesús) | - |
dc.creator | Perez-Mediavilla, L.A. (Luis Alberto) | - |
dc.creator | Santiago, E. (Esteban) | - |
dc.date.accessioned | 2011-11-09T12:55:24Z | - |
dc.date.available | 2011-11-09T12:55:24Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Lopez-Moratalla N, Migliacio M, Lopez-Zabalza MJ, Perez-Mediavilla A, Santiago E. Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides. Biochem Biophys Res Commun,1994 Dec 30;205(3):2008-2012. | es_ES |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10171/19499 | - |
dc.description.abstract | Activation of human T helper 1 cells took place when lymphomononuclear cells from healthy donors were incubated in the presence of short synthetic peptides encompassing sequences present in extracellular matrix proteins. Active peptides conformed to a common structural pattern ("2-6-11 motif") [N.López-Moratalla et al., Biochem. Biophys. Acta (1994) 1221, 153-158] conferring immunomodulating properties. The release of IL-2 and IFN gamma, as well as LAK and NK-dependent cytotoxicity induced by these peptides, could be blocked by anti-HLA-DR antibody. Activated CD4+ cells isolated from the mixed incubated population contained secretion granules with DNAase activity. These results suggest that these immunomodulating peptides presented by HLA-II play a key role in the differentiation of CD4+ T cells towards a Th1 functional phenotype. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | CD4-Positive T-Lymphocytes/drug effects | es_ES |
dc.subject | Deoxyribonucleases/biosynthesis | es_ES |
dc.subject | Peptides/pharmacology | es_ES |
dc.subject | Th1 Cells/drug effects | es_ES |
dc.subject | Adjuvants, Immunologic | es_ES |
dc.title | Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1006/bbrc.1994.2906 | es_ES |
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