(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2
Autor(es) : Lahortiga, I. (Idoya)
Belloni, E. (E.)
Vazquez, I. (Iria)
Aguirre, X. (Xavier)
Larrayoz, M.J. (María J.)
Vizmanos, J.L. (José Luis)
Valgañon, M. (Mikel)
Zudaire, I. (Isabel)
Saez, B. (Borja)
Mateos, M.C. (María C.)
Di-Fiore, P.P. (Pier Paolo)
Calasanz-Abinzano, M.J. (Maria Jose)
Odero, M.D. (Maria Dolores)
Palabras clave : Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Translocation, Genetic
Fecha incorporación: 2005
Editorial : Elsevier
Versión del editor: http://www.sciencedirect.com/science/article/pii/S016546080400305X
ISBN: 1873-4456
Cita: Lahortiga I, Belloni E, Vazquez I, Agirre X, Larrayoz MJ, Vizmanos JL, et al. NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2. Cancer Genet Cytogenet 2005 Mar;157(2):151-156.
Resumen
The t(7;11)(p15;p15.4) has been reported to fuse the NUP98 gene (11p15), a component of the nuclear pore complex, with the class-1 homeobox gene HOXA9 at 7p15. This translocation has been associated with myeloid leukemias, predominantly acute myeloid leukemia (AML) M2 subtype with trilineage myelodysplastic features, and with a poor prognosis. The derived fusion protein retains the FG repeat motif of NUP98 N-terminus and the homeodomain shared by the HOX genes, acting as an oncogenic transcription factor critical for leukemogenesis. We report here a new complex t(7;11)-variant, i.e., t(7;11;13;17)(p15;p15;p?;p1?2) in a patient with AML-M2 and poor prognosis. The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias. No other fusion transcripts involving the NUP98 or HOXA9 genes were present, although other mechanisms involving several genes on chromosomes 13 and 17 may also be involved. To our knowledge, this is the first t(7;11) variant involving NUP98 described in hematological malignancies.
Enlace permanente: http://hdl.handle.net/10171/19526
Aparece en las colecciones: DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

Ficheros en este registro:
Fichero:  2005 CGC NUP-HOX.pdf
Descripción: 
Tamaño:  220,26 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.