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dc.creatorPanizo, C. (Carlos)
dc.creatorPatiño-García, A. (Ana)
dc.creatorLecumberri, R. (Ramón)
dc.creatorCalasanz-Abinzano, M.J. (Maria Jose)
dc.creatorOdero, M.D. (Maria Dolores)
dc.creatorBendandi, M. (Maurizio)
dc.creatorRocha, E. (Eduardo)
dc.date.accessioned2011-11-10T14:26:16Z-
dc.date.available2011-11-10T14:26:16Z-
dc.date.issued2003-
dc.identifier.citationPanizo C, Patiño A, Lecumberri R, Calasanz MJ, Odero MD, Bendandi M, et al. Secondary myelodysplastic syndrome after treatment for promyelocytic leukemia: clinical and genetic features of two cases. Cancer Genet Cytogenet 2003 Jun;143(2):178-181.es_ES
dc.identifier.issn1873-4456-
dc.identifier.urihttp://hdl.handle.net/10171/19584-
dc.description.abstractAcute promyelocytic leukemia (APL) represents a biologic and clinically well-defined subtype of acute nonlymphocytic leukemia with specific morphologic and karyotypic characteristics. Although secondary leukemia and myelodysplastic syndromes (MDS) are the most frequent secondary neoplasms following chemotherapy for acute leukemia, their development after complete remission in patients with APL is uncommon. We describe the clinical and genetic features of two APL patients who achieved CR after chemotherapy and all-trans retinoid acid treatment and subsequently developed a MDS. Therapy-related MDS karyotype changes such as abnormalities of chromosomes 5 and 7 were found in the cytogenetic analysis. Since TP53 alteration was detected in one case, possible implications of these findings in the onset of MDS are discussed.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLeukemia, Promyelocytic, Acute/complications/drug therapy/geneticses_ES
dc.subjectMyelodysplastic Syndromes/complications/genetics/pathologyes_ES
dc.titleSecondary myelodysplastic syndrome after treatment for promyelocytic leukemia: clinical and genetic features of two caseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0165460802008592es_ES

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