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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study
Autor(es) : García, J.L. (J. L.)
Hernandez, J.M. (J. M.)
Gutierrez, N.C. (N. C.)
Flores, T. (T.)
Gonzalez, D. (D.)
Calasanz-Abinzano, M.J. (Maria Jose)
Martinez-Climent, J.A. (José Ángel)
Piris, M.A. (Miguel A.)
Lopez-Capitan, C. (C.)
Gonzalez, M.B. (M. B.)
Odero, M.D. (Maria Dolores)
San-Miguel, J.F. (Jesús F.)
Palabras clave : Burkitt’s lymphoma
Cytogenetics
CGH
Prognostic factor
LD-PCR
Fecha incorporación: 2003
Editorial : Nature Publishing Group
Versión del editor: http://www.nature.com/leu/journal/v17/n10/full/2403080a.html
ISSN: 1476-5551
Cita: Garcia JL, Hernandez JM, Gutierrez NC, Flores T, Gonzalez D, Calasanz MJ, et al. Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study. Leukemia 2003 Oct;17(10):2016-2024.
Resumen
Comparative genomic hybridization (CGH) studies have demonstrated a high incidence of chromosomal imbalances in non-Hodgkin's lymphoma. However, the information on the genomic imbalances in Burkitt's Lymphoma (BL) is scanty. Conventional cytogenetics was performed in 34 cases, and long-distance PCR for t(8;14) was performed in 18 cases. A total of 170 changes were present with a median of four changes per case (range 1-22). Gains of chromosomal material (143) were more frequent than amplifications (5) or losses (22). The most frequent aberrations were gains on chromosomes 12q (26%), Xq (22%), 22q (20%), 20q (17%) and 9q (15%). Losses predominantly involved chromosomes 13q (17%) and 4q (9%). High-level amplifications were present in the regions 1q23-31 (three cases), 6p12-p25 and 8p22-p23. Upon comparing BL vs Burkitt's cell leukemia (BCL), the latter had more changes (mean 4.3 +/- 2.2) than BL (mean 2.7 +/- 3.2). In addition, BCL cases showed more frequently gains on 8q, 9q, 14q, 20q, and 20q, 9q, 8q and 14q, as well as losses on 13q and 4q. Concerning outcome, the presence of abnormalities on 1q (ascertained either by cytogenetics or by CGH), and imbalances on 7q (P=0.01) were associated with a short survival.
Enlace permanente: http://hdl.handle.net/10171/19608
Aparece en las colecciones: DA - CIMA - Oncología - Oncología molecular - Artículos de Revista
DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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Fichero:  2003 Leukemia Burkitt.pdf
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