t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

Vizmanos-Pérez, J.L. (José Luis); Larrayoz, M.J. (María J.); Lahortiga, I. (Idoya); Floristan, F. (Filomena); Alvarez, C. (Carmen); Odero, M.D. (Maria Dolores); Novo-Villaverde, F. J. (Francisco Javier); Calasanz-Abinzano, M.J. (Maria Jose)

Palabras clave :

Chromosomes, Human, Pair 10/genetics
Chromosomes, Human, Pair 16/genetics
Leukemia, Monocytic, Acute/genetics
Nuclear Proteins/genetics
Oncogene Proteins, Fusion/genetics
Saccharomyces cerevisiae Proteins/genetics
Trans-Activators/genetics

Fecha de publicación :

2003

Editorial :

Wiley-Blackwell

ISSN :

1098-2264

Cita:

Vizmanos JL, Larrayoz MJ, Lahortiga I, Floristan F, Alvarez C, Odero MD, et al. t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia. Genes Chromosomes Cancer 2003 Apr;36(4):402-405.

Resumen

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.

URI :

https://hdl.handle.net/10171/19610

DOI:

http://dx.doi.org/10.1002/gcc.10174

Aparece en las colecciones:

DA - Ciencias - Bioquímica y Genética - Artículos de revista
DA - CIMA - Hemato-oncología - Leucemia aguda - Artículos de Revista

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