Full metadata record
DC Field | Value | Language |
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dc.creator | Chinwalla, V. (V.) | |
dc.creator | Chien, A. (A.) | |
dc.creator | Odero, M.D. (Maria Dolores) | |
dc.creator | Neilly, M.B. (Mary Beth) | |
dc.creator | Zeleznik-Le, N.J. (Nancy J.) | |
dc.date.accessioned | 2011-11-14T08:21:42Z | - |
dc.date.available | 2011-11-14T08:21:42Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Chinwalla V, Chien A, Odero M, Neilly MB, Zeleznik-Le NJ, Rowley JD. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. Oncogene 2003 Mar 6;22(9):1400-1410. | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19622 | - |
dc.description.abstract | The mixed lineage leukemia gene (MLL, also known as HRX, ALL-1 and Htrx) located at 11q23 is involved in translocations with over 40 different chromosomal bands in a variety of leukemia subtypes. Here we report our analysis of a rare but recurring translocation, t(11;15)(q23;q14). This translocation has been described in a small subset of cases with both acute myeloblastic leukemia and ALL. Recent studies have shown that MLL is fused to AF15q14 in the t(11;15). Here we analyse a sample from another patient with this translocation and confirm the presence of an MLL-AF15q14 fusion. However, we have also identified and cloned another fusion transcript from the same patient sample. In this fusion transcript, MLL is fused to a novel gene, MLL partner containing FYVE domain (MPFYVE). Both MLL-AF15q14 and MLL-MPFYVE are in-frame fusion transcripts with the potential to code for novel fusion proteins. MPFYVE is also located on chromosome 15, approximately 170 kb telomeric to AF15q14. MPFYVE contains a highly conserved motif, the FYVE domain which, in other proteins, has been shown to bind to phosphotidyl-inositol-3 phosphate (PtdIns(3)P). The MLL-MPFYVE fusion may be functionally important in the leukemia process in at least some patients containing this translocation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | t(11;15)(q23;q15) | es_ES |
dc.subject | MLL | es_ES |
dc.subject | AF15q14 | es_ES |
dc.subject | MPFYVE | es_ES |
dc.subject | FYVE domain | es_ES |
dc.subject | leukemia | es_ES |
dc.title | A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.nature.com/onc/journal/v22/n9/full/1206273a.html | es_ES |
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