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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Cardiotrophin-1 is a key regulator of glucose and lipid metabolism
Autor(es) : Moreno-Aliaga, M.J. (María Jesús)
Perez-Echarri, N. (Nerea)
Marcos-Gomez, B. (Beatriz)
Larequi, E. (Eduardo)
Gil-Bea, F.J. (Francisco J.)
Viollet, B. (Benoit)
Gimenez, I. (I.)
Martinez, J.A. (Jose Alfredo)
Prieto, J. (Jesús)
Bustos, M. (Matilde)
Palabras clave : Cardiotrophin-1
rCT-1
Insulin resistance
Obesity
Fecha incorporación: 2011
Editorial : Elsevier
Versión del editor: http://dx.doi.org/10.1016/j.cmet.2011.05.013
ISSN: 1550-4131
Cita: Moreno-Aliaga MJ, Perez-Echarri N, Marcos-Gomez B, Larequi E, Gil-Bea FJ, Viollet B, et al. Cardiotrophin-1 is a key regulator of glucose and lipid metabolism. Cell Metab 2011 Aug 3;14(2):242-253.
Resumen
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed that ct-1(-/-) mice develop mature-onset obesity, insulin resistance, and hypercholesterolemia despite reduced calorie intake. Decreased energy expenditure preceded and accompanied the development of obesity. Acute treatment with rCT-1 decreased blood glucose in an insulin-independent manner and increased insulin-stimulated AKT phosphorylation in muscle. These changes were associated with stimulation of fatty acid oxidation, an effect that was absent in AMPKα2(-/-) mice. Chronic rCT-1 treatment reduced food intake, enhanced energy expenditure, and induced white adipose tissue remodeling characterized by upregulation of genes implicated in the control of lipolysis, fatty acid oxidation, and mitochondrial biogenesis and genes typifying brown fat phenotype. Moreover, rCT-1 reduced body weight and corrected insulin resistance in ob/ob and in high-fat-fed obese mice. We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance.
Enlace permanente: http://hdl.handle.net/10171/19668
Aparece en las colecciones: DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Farmacia - CAFT - Artículos de revista

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