Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Calasanz-Abinzano, M.J. (Maria Jose) | - |
dc.creator | Cigudosa, J.C. (Juan Cruz) | - |
dc.creator | Odero, M.D. (Maria Dolores) | - |
dc.creator | Ferreira, C. (C.) | - |
dc.creator | Ardanaz, M.T. (M.T.) | - |
dc.creator | Fraile, A. (A.) | - |
dc.creator | Carrasco, J. (J.L.) | - |
dc.creator | Sole, F. (Francesc) | - |
dc.creator | Cuesta, B. (Braulia) | - |
dc.creator | Gullon, A. (Arturo) | - |
dc.date.accessioned | 2011-11-15T10:01:18Z | - |
dc.date.available | 2011-11-15T10:01:18Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Calasanz MJ, Cigudosa JC, Odero MD, Ferreira C, Ardanaz MT, Fraile A, et al. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations. Genes Chromosomes Cancer 1997 Feb;18(2):84-93. | es_ES |
dc.identifier.issn | 1098-2264 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19794 | - |
dc.description.abstract | Cytogenetic analysis of unstimulated short-term bone marrow cell cultures was performed on 280 patients with multiple myeloma and related disorders. In 65% of the cases, an additional short term B-cell stimulated culture was also examined. Chromosomally abnormal clones were found in 31% of the patients, 15% in Waldenström macroglobulinemia. 25% in monoclonal gammopathies, 33% in multiple myeloma, and 50% in plasma cell leukemia. Three primary chromosomal breakpoints were recurrently involved: 14q32, 16q22, and 22q11. Structural rearrangements of chromosome 1 were the most frequent (26% of the abnormal cases), but always as a secondary change. Rearrangements of band 14q32 were found in 22% of the abnormal cases. Among the multiple myeloma patients who showed an abnormal karyotype, 33 (46%) were hyperdiploid, most frequently, with 52-56 chromosomes, 29 patients (40%) were pseudodiploid, and the remaining 12 cases (14%) were hypodiploid. A highly significant relation was observed between the presence of an abnormal karyotype and the following clinical parameters: stage III (P = 0.0001), bone marrow plasma cell infiltration greater than 30% (P = 0.0001), presence of bone lesions (P = 0.0009), and beta 2-microglobulin levels greater than 4 mg/L (P = 0.0001). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Chromosome Aberrations | es_ES |
dc.subject | Chromosome Disorders | es_ES |
dc.subject | Multiple Myeloma/genetics | es_ES |
dc.title | Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bit.ly/tq2BMa | es_ES |
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