A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment

Cigudosa, J.C. (Juan Cruz); Calasanz-Abinzano, M.J. (Maria Jose); Odero, M.D. (Maria Dolores); Marin, J. (Julián); Bengoechea, E. (Enrique); Gullon, A. (Arturo)

Authors:

Cigudosa, J.C. (Juan Cruz)

Calasanz-Abinzano, M.J. (Maria Jose)

Odero, M.D. (Maria Dolores)

Marin, J. (Julián)

Bengoechea, E. (Enrique)

Gullon, A. (Arturo)

Keywords:

Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 17
Leukemia, Promyelocytic, Acute/genetics
Translocation, Genetic
Tretinoin/therapeutic use

Issue Date:

1995

Publisher:

Elsevier

Publisher Version:

http://www.sciencedirect.com/science/article/pii/016546089400182B

ISSN:

1873-4456

Citation:

Cigudosa JC, Calasanz MJ, Odero MD, Marin J, Bengoechea E, Gullon A. A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment. Cancer Genet Cytogenet 1995 Apr;80(2):160-161.

Abstract

We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. This translocation could be considered a variant of the APL-specific t(15;17). Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor alpha.

URI:

https://hdl.handle.net/10171/19795

Appears in Collections:

DA - Ciencias - Bioquímica y Genética - Artículos de revista
DA - CIMA - Hemato-oncología - Leucemia aguda - Artículos de Revista

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