Full metadata record
DC Field | Value | Language |
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dc.creator | Maceira, A.M. (Alicia M.) | |
dc.creator | Barba, J. (Joaquín) | |
dc.creator | Varo-Cenarruzabeitia, M.N. (Miren Nerea) | |
dc.creator | Beloqui, O. (Óscar) | |
dc.creator | Diez-Martinez, J. (Javier) | |
dc.date.accessioned | 2011-11-23T09:35:36Z | - |
dc.date.available | 2011-11-23T09:35:36Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Maceira AM, Barba J, Varo N, Beloqui O, Diez J. Ultrasonic Backscatter and Serum Marker of Cardiac Fibrosis in Hypertensives. Hypertension 2002 Apr;39(4):923-928. | es_ES |
dc.identifier.issn | 0194-911X | - |
dc.identifier.uri | https://hdl.handle.net/10171/19906 | - |
dc.description.abstract | Elevations in the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP) >127 microg/L have been found to predict severe myocardial fibrosis in hypertensive patients. This study was designed to assess whether ultrasonic reflectivity, evaluated by a real-time integrated backscatter analysis, was related to the severity of myocardial fibrosis as estimated by serum PIP. Thirty-four subjects were included in the study. Serum PIP was measured by specific radio immunoanalysis. Backscatter cyclic variation and maximal intensity were measured in 6 regions throughout the left ventricle. The subjects were divided into 3 groups: 14 normotensives with PIP <127 microg/L (group 1), 12 hypertensives with PIP <127 microg/L (group 2), and 8 hypertensives with PIP >127 microg/L (group 3). The highest cyclic variation was found in group 1 and the lowest in group 3 (5.78+/-0.25 versus 4.70+/-0.33 dB, P<0.05), with intermediate values in group 2 (5.10+/-0.27 dB). No differences in maximal intensity were found among the 3 groups of subjects. Using receiver operating characteristics curves, we observed that a cutoff of 2.90 dB for cyclic variation measured in the apex provided 75% sensitivity and 63% specificity for predicting PIP >127 microg/L in hypertensives, with a relative risk of 2.50 (95% CI, 0.72 to 34.70). These results show an association between diminished cyclic variation of backscatter and increased serum concentration of PIP in hypertension. Thus, the combination of these 2 parameters may be useful for the diagnosis of severe myocardial fibrosis associated with hypertension. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Heart Association | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Collagen | es_ES |
dc.subject | Hypertension, essential | es_ES |
dc.subject | Fibrosis | es_ES |
dc.subject | Peptides | es_ES |
dc.subject | Ultrasonography | es_ES |
dc.title | Ultrasonic Backscatter and Serum Marker of Cardiac Fibrosis in Hypertensives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1161/01.HYP.0000014616.48920.8F | es_ES |
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