Depósito Académico >
CIMA (Centro de Investigación Médica Aplicada) >
Área de Ciencias Cardiovasculares >
Cardiopatía hipertensiva >
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >
|Is plasma cardiotrophin-1 a marker of hypertensive heart disease?|
|Authors: ||Lopez, B. (Begoña)|
Gonzalez, A. (Arantxa)
Lasarte, J.J. (Juan José)
Sarobe, P. (Pablo)
Borras-Cuesta, F. (Francisco)
Diaz, A. (Agnes)
Barba, J. (Joaquín)
Tomas, L. (Lourdes)
Lozano, E. (Elisa)
Serrano, M. (Manuel)
Varo, N. (Nerea)
Beloqui, O. (Óscar)
Fortuño, M.A. (María Antonia)
Diez, J. (Javier)
Hypertensive heart disease
|Issue Date: ||2005|
|Publisher: ||Lippincott, Williams & Wilkins|
|Publisher version: ||http://journals.lww.com/jhypertension/Abstract/2005/03000/Is_plasma_cardiotrophin_1_a_marker_of_hypertensive.24.aspx|
|Citation: ||Lopez B, Gonzalez A, Lasarte JJ, Sarobe P, Borras F, Diaz A, et al. Is plasma cardiotrophin-1 a marker of hypertensive heart disease?. J Hypertens 2005 Mar;23(3):625-632.|
OBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH).
METHODS: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1.
RESULTS: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09).
CONCLUSIONS: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease.
|Permanent link: ||http://hdl.handle.net/10171/19914|
|Appears in Collections:||DA - CIMA - Servicios de apoyo - Biobanco - Artículos de revista|
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
|Files in This Item:|
||J Hypertens 23;625-632.pdf|
| View / Open |
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.