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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?
Authors: Lopez, B. (Begoña)
Gonzalez, A. (Arantxa)
Lasarte, J.J. (Juan José)
Sarobe, P. (Pablo)
Borras-Cuesta, F. (Francisco)
Diaz, A. (Agnes)
Barba, J. (Joaquín)
Tomas, L. (Lourdes)
Lozano, E. (Elisa)
Serrano, M. (Manuel)
Varo, N. (Nerea)
Beloqui, O. (Óscar)
Fortuño, M.A. (María Antonia)
Diez, J. (Javier)
Keywords: Cardiotrophin-1
Hypertensive heart disease
Left ventricular
Issue Date: 2005
Publisher: Lippincott, Williams & Wilkins
Publisher version:
ISSN: 0263-6352
Citation: Lopez B, Gonzalez A, Lasarte JJ, Sarobe P, Borras F, Diaz A, et al. Is plasma cardiotrophin-1 a marker of hypertensive heart disease?. J Hypertens 2005 Mar;23(3):625-632.
OBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH). METHODS: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1. RESULTS: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09). CONCLUSIONS: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease.
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Appears in Collections:DA - CIMA - Servicios de apoyo - Biobanco - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
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DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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