Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Fortuño, A. (Ana) | - |
dc.creator | Muñiz, P. (Paula) | - |
dc.creator | Zalba, G. (Guillermo) | - |
dc.creator | Fortuño, M.A. (María Antonia) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2011-11-28T11:54:16Z | - |
dc.date.available | 2011-11-28T11:54:16Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Fortuño A, Muñiz P, Zalba G, Fortuño MA, Diez J. The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats. Nephrol Dial Transplant 2001;16 Suppl 1:18-21. | es_ES |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://hdl.handle.net/10171/19977 | - |
dc.description.abstract | BACKGROUND: The direct effects of torasemide and furosemide on vasoconstriction and increases in intracellular free calcium concentration ([Ca(2+)]i) induced by endothelin-1 (ET-1) were investigated in the aorta of spontaneously hypertensive rats (SHR). METHODS: Vascular responses were assessed in endothelium-denuded aortic rings using an organ bath system. Changes of [Ca(2+)]i in cultured vascular smooth muscle cells (VSMCs) were assessed using fura-2 methodology. RESULTS: ET-1-induced vasoconstriction was reduced in a dose-dependent way by torasemide and furosemide (IC(50) values: 4.3+/-1.4x10(-5) and 9.8+/-5.6 x10(-5) M, respectively). The ET-1-induced biphasic [Ca(2+)]i increase was blocked by torasemide (IC(50)=2.0+/-0.2x10(-8) and 2.7+/-0.6x10(-6) M, respectively). Furosemide inhibited the initial rise in [Ca(2+)]i induced by ET-1, with no effect on the second rise. The specific chloride (Cl(-)) channel blocker diphenylamine-2-carboxylate inhibits both ET-1-induced responses in VSMCs (IC(50)=8.0+/-0.3x10(-9) and 2.5+/-0.7x10(-7) M, respectively). CONCLUSIONS: These results suggest that the ability of loop diuretics to interfere with the vascular actions of ET-1 may involve different molecular mechanisms. The ability of torasemide to block the vasoconstrictive action of ET-1 could include an inhibitory action on Cl(-) channels. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Endothelin-1 | es_ES |
dc.subject | Furosemide | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Torasemide | es_ES |
dc.title | The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1093/ndt/16.suppl_1.18 | es_ES |
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